-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Researchers at the Karolinska Institute in Sweden have discovered a protein that can improve muscle metabolism, motor coordination, and performance in mice
Muscle health is the main determinant of overall health, and the best way to maintain muscle health is to exercise regularly
In the current study, researchers at Karolinska Institute wanted to know how a protein produced by a muscle called neuroprotein affects neuromuscular function
"We want to know whether muscles can talk to motor neurons by sending their own messages and find out the consequences of these signals," said Jorge Ruas, professor of physiology and pharmacology at Karolinska Institutet and corresponding author
Researchers have found that compared with ordinary mice, mice that have been genetically modified to produce more neuroproteins in their muscle cells have significantly improved muscle metabolism, exercise performance, and exercise coordination
Jorge Ruas added: “The discovery that molecules released from muscle fibers can actually change the identity of motor neurons, turning them into a type related to stronger anti-degeneration ability, opens up exciting opportunities for the future.
In the next step, the researchers hope to explore the therapeutic possibilities of neuroproteins in mouse models of type 2 diabetes, obesity, and amyotrophic lateral sclerosis
Jorge Correia, the first author of the study and a researcher in the Department of Physiology and Pharmacology of Karolinska Institutet, said: "There is still a lot of work to be done, but we believe this is important for patients with metabolic and neuromuscular diseases, such as Type 2 diabetes and amyotrophic lateral sclerosis (ALS) may have therapeutic value
The researchers pointed out that this study has some limitations, including the use of genetic tools and viral vectors to increase the level of neural Turing, which is not directly applicable from a therapeutic point of view
Cell Metabolism
DOI
10.
