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Adaptive evolution of vitamin B1 metabolism genes in East Asian populations
Time of Update: 2023-01-05
On November 15, 2022, iScience published the results of the Institute of Nutrition and Health, "Archaic introgression contributed to the pre-agriculture adaptation of vitamin B1 metabolism in East As
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Using Nobel Prize-winning techniques, Nature's new research reveals a key protein mechanism involved in a wide range of cellular processes
Time of Update: 2023-01-05
Scientists have revealed the inner workings of a key protein involved in a wide range of cellular processes, which could pave the way for better, less toxic cancer drugs.
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The cellular molecular basis of cochlear aging
Time of Update: 2023-01-05
As one of the five major sensory organs, the cochlea can sense the vibration of sound waves from the outside world, convert sound signals into electrical signals and transmit them to the temporal lob
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PNAS: Where you live doesn't have as much impact as you think
Time of Update: 2023-01-05
essayImpact of cultural and genetic structure on food choices along the Silk Road Image: Figure 1.
essayImpact of cultural and genetic structure on food choices along the Silk Road Image: Figure 1.
essayImpact of cultural and genetic structure on food choices along the Silk Road Image: Figure 1.
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Genes that guide early social behavior may be key to understanding autism
Time of Update: 2023-01-05
The study also showed that exposure to certain drugs and environmental risk factors during embryonic development leads to changes in the gene that lead to changes in social behavior similar to those found in people with autism.
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Nature Communications published the research results of the continuous breaking of carbon-carbon bonds by Sun Zhankui's team at the School of Pharmacy of Shanghai Jiaotong University
Time of Update: 2023-01-05
Recently, the internationally renowned journal Nature Communications published the latest research results of Sun Zhankui's research group of Shanghai Jiao Tong University School of Pharmacy entitled "Decarboxylative oxidation-enabled consecutive C-C bond cleavage".
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Concern! PD-1 immune blockade promotes the drive of tumor NLRP3-HSP70-TLR4 axis to pre-metastasis niche/tumor hyperprogression
Time of Update: 2023-01-05
The study showed that++tumor NLRP3-HSP70 axis also drove the accumulation of "granulocyte polymorphonuclear myeloidal inhibitory cell PMN-MDSCs" into distant lung tissues in a manner that relied on Toll-like receptor 4 (TLR4) signaling in lung epithelial cells, thereby establishing a pre-metastatic niche that supported disease progression after anti-PD-1 immunotherapy.
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Achieved! Humans are trained to control objects with their "minds."
Time of Update: 2023-01-05
"It seems that for a person to have good brain-computer interface control that allows them to perform relatively complex daily activities, such as driving a wheelchair in a natural environment, this requires some neuroplasticity reorganization in our cortex," Millán said.
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After prolonged chemotherapy, gut microbes promote the production of neutrophils
Time of Update: 2023-01-05
" The results of a study by researchers at Hokkaido University School of Medicine show that the composition of the gut microbiome is crucial for driving a process known as granulogenesis, which can replenish the number of neutrophils in the blood of mice after undergoing treatments such as hematopoietic stem cell transplantation (SCT) or chemotherapy.
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Nature sub-issue: MIT's newly developed CRISPR-based "paste" tool
Time of Update: 2023-01-05
"Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases Building on the CRISPR gene-editing system, MIT researchers have devised a new tool that can cut out defective genes and replace them with new ones in a safer and more efficient way.
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Nature Medicine: How genes and small molecules affect our individual disease risk
Time of Update: 2023-01-05
Scientists at the University of Bosnia and Herzegovina have now identified rare and common changes in the genetic code that affect an individual's chemical fingerprint and personal disease profile.
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Two top journals in a row, revealing surprising new roles for the spinal cord and brainstem in touch
Time of Update: 2023-01-05
"Similar to the study of the visual system, these two papers explore how touch information from the skin is processed in the spinal cord and brainstem before moving up to more complex brain regions," Ginty said.
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A discovery reveals that "brain-like computing" is possible at the molecular level
Time of Update: 2023-01-05
Professor Thompson explains: "It was a great lockdown project where Chris, Enrique and I pushed each other through scaled meetings and a huge email process, bringing our team's combined skills in materials modeling, synthesis, and characterization to a point where they could demonstrate these new brain-like computational properties.
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Krill oil protects dopaminergic neurons from age-related degeneration
Time of Update: 2023-01-05
"Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging Figure 7.
"Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging Figure 7.
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Deadly cancer cells have learned to "help each other" in order to survive
Time of Update: 2023-01-05
"Without blood vessels, PDA cells can't get the normal nutrients they need, so they come up with other ways to nourish themselves and grow," said Christopher Halbrook, assistant professor of molecular biology and biochemistry and principal and co-corresponding author.
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A new artificial intelligence blood test can detect liver cancer
Time of Update: 2023-01-05
"Increasing early detection of liver cancer can save lives, but the screening tests currently available are underutilized and miss many cancers," said Victor Velculescu, MD, professor of oncology at the Kimmel Cancer Center at Johns Hopkins University and co-director of the Cancer Genetics and Epigenetics Program, along with Zachariah Foda, MD, Gastroenterology Researcher, Akshaya Annapragada, MD.
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The research group of Jiao Jianwei of the Institute of Zoology revealed a new mechanism of human specific genes to promote cerebral cortex folding
Time of Update: 2023-01-05
This study found that the human-derived gene SERPINA3 promoted the expansion and folding of the mouse cortex, increased the number of upper neurons, and significantly improved the cognitive ability of the mice.
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Wang Jiangyun/Chen Yongxiang's research group in the study of genetically encoded phosphine ligands and artificial metalloprotein (enzyme) design...
Time of Update: 2023-01-05
On November 23, 2022, the journal JACS published a research paper entitled "Genetically Encoded Phosphine Ligand for Metalloprotein Designn" by Wang Jiangyun's group and Chen Yongxiang's group of Tsi
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PNAS: RNA-targeted strategies repair genetic causes of amyotrophic lateral sclerosis and dementia
Time of Update: 2023-01-05
"Article A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome Photo caption: Jessica Bush, a graduate student at the Scripps Institute for Biomedical Research at the University of Florida, is in discussions with her mentor, Matthew Disney, chair of the chemistry department.
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Endogenic immune mechanisms that promote axon regeneration in the adult nervous system
Time of Update: 2023-01-05
Image source: Hong Kong University of Science and TechnologyIn the central nervous system, such as retinal ganglion cells, IFNγ activates STAT1 in Ptpn2 cKO RGCs. STAT1 then upregulates the expression of neuronal cGAS.
