Krill oil protects dopaminergic neurons from age-related degeneration

"Therefore, krill oil supplementation may be a possible way
to intervene in healthy brain aging.
"

A new research paper published in Aging (Aging-US), Vol.
14, No.
21, titled "Squamous shrimp oil protects dopaminergic neurons from age-related degeneration
by timing transcriptome reorganization and inhibition of several markers of aging.
" ”

There is growing evidence that interfering with basic aging mechanisms can extend healthy lifespans
.
Intervention/treatment strategies that target multiple markers of aging may be more effective
than targeting a single marker.
While the health-promoting properties of offshore oil have been extensively studied, the underlying molecular mechanisms are not fully understood
.

The lipid extract of Antarctic krill is rich in long-chain omega-3 fatty acids, choline, and astaxanthin
.
In the new study, researchers used Caenorhabditis elegans and human cells to investigate whether krill oil promotes healthy aging
.

"In Caenorhabditis elegans, we found that krill oil protects dopaminergic neurons from aging-related degeneration, reduces α-synuclein aggregation, and improves dopamine-dependent behavior and cognition
.
"

Krill oil reprogrammed different gene expression programs to help attenuate several characteristics of aging, including oxidative stress, protein toxic stress, aging, genomic instability, and mitochondrial dysfunction
.
Mechanistically, krill oil promotes oxidative stress and anti-inflammation through time-transcriptome recombination, and promotes antioxidant stress and anti-inflammation through healthy period-regulating transcription factors such as SNK-1
.
In addition, krill oil promotes the survival
of dopaminergic neurons by regulating synaptic transmission and neuronal function of PBO-2 and RIM-1.

"Overall, krill oil reprogrammed the global gene expression program and promoted healthy aging by eliminating multiple markers of aging, pointing the way
for further preclinical and clinical exploration.
"

Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging