Nature Communications published the research results of the continuous breaking of carbon-carbon bonds by Sun Zhankui's team at the School of Pharmacy of Shanghai Jiaotong University

Recently, the internationally renowned journal Nature Communications published the latest research results
of Sun Zhankui's research group of Shanghai Jiao Tong University School of Pharmacy entitled "Decarboxylative oxidation-enabled consecutive C-C bond cleavage".

The breaking and construction of carbon-carbon bonds is the basic content of organic chemistry research, and the selective breaking of carbon-carbon bonds is a big problem in the field of organic synthesis, especially the selective breaking of C(sp3)-C(sp3) bonds is extremely challenging
.
Based on photocatalytic decarboxylation and combined with copper catalytic oxidation, Sun Zhankui's group developed a continuous fracture method for carbon-carbon bonds, which can achieve selective fracture
of C(sp3)-C(sp3) bonds under mild conditions.
In this study, using α-trisubstituted carboxylic acid as substrate, a carbon-carbon bond continuous fracture method was developed by oxidative decarboxylation reaction, combined with photocatalysis and copper catalysis, which can achieve selective fracture
of C(sp3)-C(sp3) bonds under mild conditions.

The mechanism of this reaction is complex, and there may be two pathways, involving the breaking
of multiple carbon-carbon bonds in between.
The authors achieved selective cleavage of C(sp3)-C(sp3) bonds on more than 40 different substrates and applied them to drug synthesis as well as natural product modification
.

Dr.
Li Ruining and Postdoctoral Dong Ya of Shanghai Jiao Tong University School of Pharmacy are the co-first authors of the paper, and Professor Sun Zhankui is the corresponding author
of the paper.
Dr.
Shah Nawaz Khan, Muhammad Kashif Zaman, Dr.
Junliang Zhou, Pannan Miao, and Lifu Hu are co-authors
of the paper.
The above work was completed
with the funding of Shanghai Jiao Tong University and the National Talent Program.

Link to the paper: