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The biggest innovation in sperm selection technology in 30 years: the first syringe to separate high-quality sperm in 15 minutes
Time of Update: 2023-01-05
Monash University has developed a syringe that uses a 3D filter to detect viable sperm, which can improve sperm quality selection by 65%, bringing new hope to infertile couples.
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The important role of transcription factor MESP1 combined with epigenetic modification protein RING1A in heart development was published
Time of Update: 2023-01-05
On November 21, 2022, Sun Ning's team from the School of Basic Medicine of Fudan University and the School of Medicine of Wuxi of Jiangnan University and Lan Fei's team from the Institute of Biomedical Sciences (IBS) of Fudan University published an online report titled Essential role of MESP1-RING1A complex in Developmental Cell The work of cardiac differentiation.
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Lin Aifu and other teams of Zhejiang University jointly developed a post-translational modification based on immune checkpoint molecules...
Time of Update: 2023-01-05
In recent years, the immune checkpoint blockade therapy with PD-1/PD-L1 inhibitors as the typical representative has made important progress in tumor treatment. However, due to the individual heterog
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This "super enhancer" has been used for more than 1 billion years! The latest study in the journal Cell has discovered the mechanisms that allow multicellular formation
Time of Update: 2023-01-05
”Original:Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response A new study from the University of Chicago has found that the mechanisms by which mammalian cells drive cell differentiation also play a key role in activating yeast genes in response to environmental stressors.
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The joint research group of Hu Youfan-Peng Lianmao of the School of Electronics has made important progress in the research of high-speed flexible circuits
Time of Update: 2023-01-05
This work realizes for the first time a high-speed flexible integrated circuit with sub-nanosecond gate delay based on flexible devices, and fully demonstrates the application potential of flexible carbon nanotube transistors in the field of high-speed, low-power flexible circuits.
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Gao Ning's research group in the School of Life Sciences revealed the functional molecular mechanism of the ribosome assembly factor Drg1
Time of Update: 2023-01-05
In this study, cryo-EM was used to analyze the structure of Drg1 in the state of multiple nucleotides and the structure of hexamer in the substrate bound state, and the molecular mechanism of Drg1 function was elucidated in detail based on high-resolution structure and biochemical data analysis.
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Nature Metabolism: Poor diet damages our blood vessels
Time of Update: 2023-01-05
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity The team found that metabolic diseases affect the blood vessels of different organs of the body in unique ways.
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Pain relievers such as ibuprofen and naproxen may worsen inflammation in arthritis
Time of Update: 2023-01-05
" Future prospective randomized studies should be conducted to provide conclusive evidence of the anti-inflammatory effects of NSAIDs. Taking anti-inflammatory painkillers such as ibuprofen and naproxen to treat osteoarthritis may worsen knee joint inflammation.
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Functional specialization of different PI3K subtypes in controlling neuronal structure, synaptic plasticity, and cognition
Time of Update: 2023-01-05
Result highlightsProteomic analysis of mice lacking neurons p110α or p110β showed differences in cellular processes controlled by the two isotypes, suggesting that the P110α and p110β subtypes may play different roles in synaptic function and intracellular signaling.
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Science: Novel gene therapies targeting overactive brain cells hold promise for treating neurological disorders
Time of Update: 2023-01-05
To develop the new gene therapy, the authors screened several genes known to be activated in response to stimuli and coupled their promoters to potassium channels selected for reducing nerve cell firing.
com)Resources:Yichen Qiu et al.
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"DNA virus vaccines" can be used to stop viral infections
Time of Update: 2023-01-05
Rutgers scientists have developed a new way to stop viral infections: a so-called live, replicated, defective DNA virus vaccine that uses a compound called centanamycin to create a mutated virus for vaccine development.
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Cell Rep: HIV infection leaves a "memory" in cells
Time of Update: 2023-01-05
”Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells Although antiretroviral therapy has made HIV a controllable disease, people living with HIV often suffer from chronic inflammation.
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Neurology, an antioxidant has been linked to slowing memory decline
Time of Update: 2023-01-05
According to a study published in the November 22, 2022 issue of the American Academy of Neurology, an online issue of the medical journal Neurology, people who eat or drink more foods containing antioxidant flavonols may experience slower memory decline, which is found in several fruits and vegetables, as well as tea and wine.
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Genomic studies have revealed a new branch of fungal evolution
Time of Update: 2023-01-05
0)Photo by Alan RockefellerA team led by the University of Alberta says about 600 distinctly different looking fungi have a common ancestor that never found a proper place in the fungal family tree.
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Professor Huang Jia's research group from the College of Agriculture published a paper in Science Advances to reveal new targets for insecticides
Time of Update: 2023-01-05
Figure 1: Schematic diagram of the mechanism of action of flufenamide Through a series of experiments such as behavioral genetics, enzyme kinetics, and comparative pharmacology in Drosophila, the authors found that nicotinamide is specifically expressed in the chordal neuron of Drosophila, and the metabolite T FNA-AM of flufenamide in worms leads to the accumulation of the substrate nicotinamide by inhibiting nicotinase activity, thereby overactivating T RPV ion channels produce symptoms of toxicity (Figure 1).
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The heart-damaging SARS-CoV-2 protein has been found!
Time of Update: 2023-01-05
In addition, protein genes involved in glycolysis (the breakdown of glucose into usable energy) were upregulated in muscle heart cells or cardiomyocytes of Nsp6 fruit flies.
In addition, protein genes involved in glycolysis (the breakdown of glucose into usable energy) were upregulated in muscle heart cells or cardiomyocytes of Nsp6 fruit flies.
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A novel mechanism by which ARID2 regulates lipid homeostasis in the liver
Time of Update: 2023-01-05
1038/s41418-022-01090-0 On November 17, 2022, the international academic journal Cell Death & Differentiation published online the research results of Xie Dong's research group entitled "ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2" by the Xie Dong research group of the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences 。 This study reveals the important role of ARID2 in the development and development of NAFLD and provides a promising therapeutic strategy for NAFLD patients with ARID2 deficiency.
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Nat Commun Shanghai Institute of Materia Medica: Jointly constructs a surface function biomimetic nanodrug carrier to improve the effect of oral insulin therapy
Time of Update: 2023-01-05
Construction of biomimetic viral nanocarriers with surface ligand conversion and in vivo delivery (Contributing department: Gan Yong Research Group; Contributor: Yang Tiantian) Diabetes is a chronic metabolic disease that seriously threatens human health.
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How "history" shapes people's DNA
Time of Update: 2023-01-05
” Although health care and economic theories for pregnant women have evolved since the 2030s, Schmitz believes that studies like this can shed light on today's social problems.
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Developmental Cell: Recreate the adrenal glands in a petri dish
Time of Update: 2023-01-05
Original searchReconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells The adrenal glands are located above the kidneys on both sides and play a key role in maintaining human health.
