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Scientists uncover molecular switch for heart disease
Time of Update: 2022-09-07
Understanding how genes are turned on or off in the hearts of heart patients, and how drugs can reverse these changes and improve heart function, is the focus of research by Dr Michael Alexandrian, who joined the Gladstone Institute, as an assistant researcher .
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Cell upgrades 1000 Genomes Project resources: high-coverage whole-genome sequencing and improved analytical methods
Time of Update: 2022-09-07
Graphical summary of the study "High-Coverage Whole-Genome Sequencing of the Expanded 1000 Genomes Project Including 602 Trios" Source: Marta Byrska-Bishop (New York Genome Center)Researchers Expand
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Science Advances Luo Donggen's team discovers a new type of electrical signal that maintains circadian rhythms
Time of Update: 2022-09-07
On September 2, 2022, the team of Luo Donggen from the Academy of Sciences of Peking University, the McGovern Institute for Brain Research, the Center for Quantitative Biology, and the Joint Center for Life Sciences published a research paper on "An extra-clock ultradian brain oscillator sustains circadian timekeeping" in Science Advances, reported A novel electrical signal and its neural mechanism for maintaining circadian rhythm .
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Seeds can spread tomato spotted wilt virus
Time of Update: 2022-09-07
In the process of researching the serious diseases of pepper in Yanqing area of Beijing, the team of Ye Jian of the Institute of Microbiology found that the tomato plant and the virus-transmitting insect thrips were detected by pathogenicity, and the virus N gene was sequenced and evolutionary analysis.
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A Novel Chimeric Antigen Receptor T-Cell Approach to Treat Liver Cancer
Time of Update: 2022-09-06
Recently, the research team of Han Zeguang from the Institute of Systems Biomedicine, Shanghai Jiao Tong University published an article titled DLK1-directed chimeric antigen receptor T-cell therapy for hepatocellular carcinoma online in the well-known academic journal Liver International, revealing a novel targeting membrane protein DLK1.
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Shanghai Jiaotong University Fang Yuda's research group reveals the molecular mechanism of histone variant H2A.Z finely regulating auxin signaling
Time of Update: 2022-09-06
Z. On August 26, 2022, Professor Fang Yuda's group from the School of Agriculture and Biology, Shanghai Jiao Tong University published a paper entitled "Feedback regulation of auxin signaling through the transcription of H2A.
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Shape of coronavirus affects its spread, study finds
Time of Update: 2022-09-06
0094771 Now, a global team of researchers, including scientists from Queen's University in Canada and the Okinawa Institute of Science and Technology (OIST) in Japan, has simulated how different elliptical shapes affect the way these virus particles rotate in the liquid, affecting the ease with which the virus spreads degree .
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SMNDC1 deletion induces insulin production in alpha cells
Time of Update: 2022-09-06
article titleSMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression Figure: Immunofluorescence images of alpha cells showing induction of insulin protein after SMNDC1 deletion Beta cells in the pancreas are responsible for producing the important hormone insulin .
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Combination drug therapy in mice can block drug resistance and stop tumor growth
Time of Update: 2022-09-06
Image credit: Simone Hausmann and Pawel MazurAccording to a study in mice conducted by researchers at Washington University School of Medicine in St. Louis, the University of the Alpes in Grenoble, France, and the MD Anderson Cancer Center at the University of Texas in Houston, experimental combinations of the two drugs could stop the development of small cell lung cancer, the deadliest form of lung cancer.
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How a rare genetic mutation can lead to intellectual disability
Time of Update: 2022-09-06
”Article titleF?rster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKIIa activity in de novo mutations related to intellectual disability Figure: In this graph, the red line represents the enzyme activity of the P212L mutant protein over time, while the blue line represents the activity of the regular, unmutated protein.
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"Science Bulletin" online published an article by Jin Hongfang and Du Junbao's team of Peking University Hospital "How to identify vasovagal syncope in children and mental pseudosyncope?"
Time of Update: 2022-09-06
This article mainly analyzes the main differences in pathogenesis, clinical manifestations and auxiliary examinations between VVS and PPS, finds out the main problems of previous differential diagnosis methods, and analyzes and evaluates two recently proposed auxiliary differential scoring systems .
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Science Advances: New technologies provide avenues for finding treatments for kidney disease
Time of Update: 2022-09-06
Researchers at McKelvey College of Engineering and School of Medicine have invented a technique that shows them how kidney changes linked to diabetes and elevated blood sugar affect the mechanical function and resilience of podocytes, which has the potential to find new treatments for chronic kidney disease.
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Cell Stem Cell creates a new human cell type!
Time of Update: 2022-09-06
”Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells From left to right: Bradley Balaton, Thi Xuan Ai Pham, Amitesh Panda and Vincent Pasque.
”Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells From left to right: Bradley Balaton, Thi Xuan Ai Pham, Amitesh Panda and Vincent Pasque.
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Synthetic protein for protection against chemical weapons attack
Time of Update: 2022-09-06
A team including Rutgers scientists has engineered a synthetic protein that can rapidly detect the molecules of a deadly nerve agent that has been classified by the United Nations as a weapon of mass destruction for use in chemical warfare attack .
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Mitochondria are 'stressed' and help cells survive respiratory infections?
Time of Update: 2022-09-06
Tetracycline-induced mitohormesis mediates disease tolerance against influenza Many respiratory infections, such as the flu or COVID-19, can place significant stress on cells and organs, leading to acute respiratory distress syndrome (ARDS), which itself can ultimately lead to death in elderly or sensitive individuals .
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Wuhan University, Zhongnan Hospital PNAS issued a paper: New progress of human V-ATPase and mTOR
Time of Update: 2022-09-06
2203742119 Recently, the Proceedings of the National Academy of Sciences of the United States of America (PNAS) published online the research on human V-ATPase and mTOR by Wang Longfei, a professor at the School of Pharmacy of Wuhan University and the Institute of Pharmacy of Zhongnan Hospital.
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Scientists have found that a compound in trees has the potential to kill drug-resistant bacteria
Time of Update: 2022-09-06
”Article title Hydroquinine Possesses Antibacterial Activity, and at Half the MIC, Induces the Overexpression of RND-Type Efflux Pumps Using Multiplex Digital PCR in Pseudomonas aeruginosa The researchers discovered a naturally occurring compound called hydroquinine that has bactericidal activity against several microorganisms.
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Challenging conventional evolutionary views: corals pass on mutations acquired during their lifetime to future generations
Time of Update: 2022-09-06
In a discovery that challenges a century of conventional wisdom on evolution, corals have been shown to pass somatic mutations -- changes in DNA sequences that occur in non-germ cells -- to their offspring .
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Stanford researchers solve 'chemical brain' mystery
Time of Update: 2022-09-06
"Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairment Renowned Saint Louis University pain researcher Dr. Daniela Salvemini and her team .
"Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairment Renowned Saint Louis University pain researcher Dr. Daniela Salvemini and her team .
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The team of Professor Fang Yuda of Shanghai Jiaotong University reveals the uncoupling mechanism between the three-dimensional structure of chromatin and gene transcription in tetraploid rice
Time of Update: 2022-09-06
822) Published a research paper online entitled "DNA methylation in transposable elements buffers the connection between three-dimensional chromatin organization and gene transcription upon rice genome duplication", revealing the transposon forma regulated by rice genome duplication Sylation attenuated the effects of A/B compartment transitions and TAD boundary gene alterations in chromatin 3D structure on gene transcription, leading to uncoupling between chromatin 3D structure changes and gene transcription when the rice genome doubled .
