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Recently, the Proceedings of the National Academy of Sciences of the United States of America (PNAS) published online the research on human V-ATPase and mTOR by Wang Longfei, a professor at the School of Pharmacy of Wuhan University and the Institute of Pharmacy of Zhongnan Hospital.
The title of the paper is "Identification of mEAK-7 as a human V-ATPase regulator via cryo-EM data mining"
Studies have shown that V-ATPases mediate many important signal transduction processes, including Wnt, mTOR, and Notch, etc.
To identify V-ATPase binding partners, the authors performed multiple rounds of classification and focused refinement based on a large cryo-electron microscopy dataset of human V-ATPase purified from HEK293 cells
This study lays the foundation for future studies on the role of mEAK-7 in mTOR signaling and V-ATPase regulation
The structure and interaction of mEAK-7 and V-ATPase
Wang Longfei's research group has been engaged in structural pharmacology research for a long time, mainly focusing on important targets of innate immunity and inflammation, as well as the interaction between pathogenic microorganisms and the host.
Paper link: https://doi.
