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Figure: Immunofluorescence images of alpha cells showing induction of insulin protein after SMNDC1 deletion
Beta cells in the pancreas are responsible for producing the important hormone insulin
Insulin is a hormone of the pancreas that regulates blood sugar levels in the body and directly or indirectly affects many metabolic processes
Beta cells are present in the pancreas, particularly in clusters of cells in the islets of Langerhans
Tamara Casels, a doctoral student in Kubicek's lab, investigated the fundamental question of which factors in alpha cells inhibit insulin production to determine which factors induce this important hormone when inhibited.
Loss of ATRX leads to insulin induction
Tamara Castles was able to show that reducing the expression of the chromatin protein SMNDC1 causes the insulin gene to be turned on in alpha cells
Further effects of SMNDC1 knockout remain
This research brings important fundamental insights
To better test dose-dependent effects, the role of SMNDC1 in other tissues, and the potential to bind to other factors that affect alpha cell identity, researchers in Kubicek's lab are currently developing small-molecule inhibitors of SMNDC1
article title
SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression
