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Professor Shen Juntai's team has made important progress in the study of the structure of the Andromeda Galaxy (M31)
Time of Update: 2022-08-20
Why do shock waves in interstellar gas serve as evidence for the existence of rods?Previously, astronomers suggested that M31 may contain a galaxy bar based on the distortion of the stellar isoluminosity, but this phenomenon is not necessarily produced by a bar, but also by a non-rotating ellipsoid bulge .
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Aging feminizes male brains and masculinizes females
Time of Update: 2022-08-20
Antonino Malacrinò, one of the study's lead authors, now at the University of Regio Calabria in Italy, said: "Our results show that with age, gene expression in male and female brains becomes more similar, And both sexes contribute to this pattern .
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Drinking alcohol changes gut microbes, but not in the way you think
Time of Update: 2022-08-20
In a new study published August 8, 2022 in the journal Nature Communications, UC San Diego researchers and colleagues elsewhere propose an answer: The reprogramming of the gut microbiome is produced by the liver Caused by the diffusion of acetate back into the gut, where it becomes a carbon source that supports bacterial growth .
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CELL MOL LIFE SCI Ji Xiong's research group reveals the functional mechanism of BRD2-mediated RNA polymerase II transcription
Time of Update: 2022-08-20
On June 4, 2022, Ji Xiong's group from the School of Life Sciences and the Life Center of Peking University published an online article entitled "BRD2 interconnects with BRD3 to facilitate Pol II transcription initiation and elongation to prime promoters for cell differentiation" in the journal Cellular and Molecular Life Sciences research paper .
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"Science" Zhang Feng's team discovered a new antiviral defense system in bacteria
Time of Update: 2022-08-20
They found that certain proteins in bacteria and archaea (collectively known as prokaryotes) detect viruses in a surprisingly direct way, identify key parts of the virus, and cause single-celled organisms to commit suicide to quell infections in microbial communities .
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The Materials Genome Team of Shanghai Jiaotong University has made important progress in modeling and prediction of the volume effect of alloy solid solutions
Time of Update: 2022-08-20
Recently, the Materials Genome Team led by Professor Wang Hong from the School of Materials Science and Engineering, Shanghai Jiao Tong University published online on the volume effect machine learning (ML) of Binary Substitutional Alloy Solid Solution (BSMSS) in Acta Materialia, the top international journal in the field of metal materials.
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Daewoong Pharmaceutical Announces U.S. FDA Approval of its IND Application for DWP213388, the First-in-Class Oral, Irreversible, Dual-Acting Antifungal Drug for the Treatment of Autoimmune Diseases
Time of Update: 2022-08-20
, Ltd —DWP213388 is the first-in-class dual-target inhibitor that simultaneously inhibits pathogenic T cells and B cells in various autoimmune diseases SEOUL, South Korea, Aug. 15, 2022 /PRNewswire/ -- Daewoong Pharmaceutical, a publicly listed South Korean company that develops, manufactures and sells pharmaceuticals globally, announced today that the company's Investigational New Drug (IND) application has been approved in the U.
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Creating an 'adult-like' mature human heart tissue
Time of Update: 2022-08-20
Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes Researchers in the UConn Department of Biomedical Engineering have developed a new cardiac cell-derived platform that closely mimics the human heart, unlocking the potential for more thorough preclinical drug development and testing, and modeling heart disease .
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Zhao Yang's research group realizes chemical induction of fibroblasts into hepatocytes with metabolic and regenerative functions
Time of Update: 2022-08-20
This study developed a system that uses a chemical small molecule approach to stepwise activate endogenous transcription factors to induce reprogramming of fibroblasts into functional hepatocytes .
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Clearing the fog, new method brings more realistic single-cell RNA sequencing data
Time of Update: 2022-08-20
Recently, a research team at the Institute for Advanced Study in Human Biology at Kyoto University has developed a new mathematical method that can remove noise and help people extract clear signals from single-cell RNA-sequencing data .
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Natuer Publishes Key Mechanisms of COVID-19 Virus Replication
Time of Update: 2022-08-20
" Molecular mechanisms responsible for SARS-CoV-2 RNA cap synthesis A team led by researchers at the University of Texas Southwestern has determined how the SARS-CoV-2 virus that causes COVID-19 builds a structure called the RNA cap, which is critical to the virus's successful replication .
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Nature Cancer: cfDNA methylation profiles provide clues for the treatment of small cell lung cancer
Time of Update: 2022-08-20
Methylation profiles of circulating cell-free DNA (cfDNA) in the blood can help distinguish tumor subtypes in patients with small cell lung cancer and provide potential therapeutic clues, a team led by the University of Manchester has found .
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Overturn old theories!
Time of Update: 2022-08-20
"Mental fatigue also appears to shift decision-making toward a simple push-button mode, said study co-author Antonius Wiehler, a cognitive neuroscientist at the Motivation, Brain and Behavior Laboratory at the Paris Institute for Brain Research.
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Mobile 'front-loading washing machine' that aids DNA replication
Time of Update: 2022-08-20
"Computationally exploring the mechanism of bacteriophage T7 gp4 helicase translocating along ssDNA The simulations show how the hexagonal helicase protein separates double strands into single strands along the DNA strand during replication .
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Zhu Shuijin's team from the College of Agriculture published a paper in Plant Communications to analyze the evolution of the whole genome of Bick's cotton and the formation mechanism of pigment glands and gossypol
Time of Update: 2022-08-20
On August 10, 2022, Zhu Shuijin's team from the College of Agriculture published a research paper entitled "A reference-grade genome assembly for Gossypium bickii and insights into its genome evolution and formation of pigment gland and gossypol" in the journal Plant Communications .
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Chinese scholars have made progress in revealing the role of plastics in estuarine nitrous oxide emissions
Time of Update: 2022-08-20
Fig. 1 Bioformation process on plastic surface (a) and content of extracellular polymer components (bd) Fig. 2 N2O production capacity (a) and denitrification rate (b) Funded by the National Natural Science Foundation of China (Grant No. 42021005, 42003060), Zhu Yongguan's team from the Institute of Urban Environment, Chinese Academy of Sciences has made new progress in revealing the role of plastics in estuarine nitrous oxide emissions.
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Shanghai Jiaotong University Yang Xuanming's team discovered a new target for CAR-T treatment of T-cell malignant tumors
Time of Update: 2022-08-20
Recently, the internationally important academic journal "Nature Communications" published online the research results "T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies" by Yang Xuanming's team from Sheng Yushou Cell and Immunology Research Center of Shanghai Jiao Tong University .
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New target for treating diseases of premature aging
Time of Update: 2022-08-20
"These findings provide new insights into progeria-like syndromes and their treatments, while also highlighting the importance of LINE-1 RNA in normal aging," said Salk Professor in the Gene Expression Laboratory, Altos Laboratory at the San Diego Institute of Science Director and co-corresponding author Juan Carlos Izpisua Belmonte said .
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The Institute of Zoology of the Chinese Academy of Sciences cooperates to establish an in vitro life breeding platform: the bionic uterus cultivates blastocysts until the heartbeat appears
Time of Update: 2022-08-20
In order to be more conducive to the development of embryos in vitro, the joint team first systematically analyzed the physical and chemical properties of the uterus, grafted collagen gel onto polydimethylsiloxane, screened a series of conditions, and finally successfully simulated the uterine microenvironment (Bionic Uterus (UN) ) to prepare an artificial uterus (Figure 1, Figure 2) .
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Nature: Spatial copy number analysis promises to distinguish benign from malignant tissue
Time of Update: 2022-08-20
Recently, researchers from the Royal Institute of Technology in Sweden, the University of Oxford and other institutions have demonstrated that spatial analysis of copy number patterns in benign and malignant tissues can provide new insights into the clonal evolution of cancer .
