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Chronic alcohol use is a leading cause of liver damage and death: About 30,000 people in the United States die each year from alcoholic liver disease, such as cirrhosis
In a new study published August 8, 2022 in the journal Nature Communications, UC San Diego researchers and colleagues elsewhere propose an answer: The reprogramming of the gut microbiome is produced by the liver Caused by the diffusion of acetate back into the gut, where it becomes a carbon source that supports bacterial growth
"You can think of this as dumping fertilizer in a garden," said corresponding author Karsten Zengler, Ph.
Bernd Schnabl, professor of medicine and gastroenterology at UC San Diego School of Medicine, is the other corresponding author
Acetate is a nutrient used in cellular metabolism and plays a role in appetite regulation, energy expenditure, and immune responses
In the latest study, Zengler and his colleagues fed mice a molecule that breaks down into three acetates in the mice's guts
"Chronic alcohol consumption is associated with the expression of antimicrobial molecules down the gut
The findings are important, the authors say, because they focus their investigation on "whether changes in the gut microbiome are related to ethanol consumption itself.
