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Solving a 30-year-old puzzle: Scientists discover new protein structures to help rationally design drugs
Time of Update: 2022-08-15
"article titleStructural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists In a major advance in rational drug design, a Texas A&M University Agricultural Life team has characterized the structures of several proteins that play a key role in cellular processes .
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Risk factors for dementia may vary with age
Time of Update: 2022-08-15
org, the homepage of the American Academy of Neurology's free patient and caregiver magazine, focusing on the intersection of neurological disease and brain health Learn more about dementia at BrainandLife.
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Professor Qu Kun's research group systematically evaluated 16 spatial transcriptome and single-cell transcriptome data integration...
Time of Update: 2022-08-15
Qu Kun from the Department of Life Science and Medicine, University of Science and Technology of China has systematically evaluated the performance of 16 16 16 spatial transcriptome and single-cell transcriptome data integration algorithms in predicting the spatial distribution of genes or cell types by designing a complete set of analysis procedures.
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Deng Hongkui and Li Cheng cooperate to establish a new type of totipotent stem cells with the ability to form blastocysts using mouse two-cell embryos
Time of Update: 2022-08-15
This novel totipotent stem cell can be stably cultured for a long time in vitro, is highly similar to mouse two-cell embryos in molecular characteristics and developmental potential, and can be induced in vitro to form blastocysts that are similar to blastocysts in vivo at the transcriptomic level structure .
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In vivo manufacturing of CAR cell therapy cutting-edge Announces Circular RNA Proof-of-Concept Data
Time of Update: 2022-08-15
Retrieved May 17, 2022, from https:// /?utm_source=socialmedia A few days ago, Orna Therapeutics, a company dedicated to the development of circular RNA therapeutics, announced for the first time the preclinical proof-of-concept data of its flagship isCAR project .
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Nearly 60% of patients' skin symptoms are almost completely cleared!
Time of Update: 2022-08-15
Bristol-Myers Squibb (BMS) today announced two-year results from the POETYK PSO Long-Term Extension (LTE) trial, supporting the durable efficacy and consistent safety profile of deucravicitinib in adults with moderate-to-severe plaque psoriasis .
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Ding Changhai's team from Pearl River Hospital has achieved a series of research results in the treatment of arthritis with stem cells and nanomaterials
Time of Update: 2022-08-15
. Another research result of the team "Highly effective rheumatoid arthritis therapy by peptide-promoted nanomodification of mesenchymal stem cells" was published in the journal "Biomaterials", the first area of engineering technology .
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Cell: 'Remote Control' CAR-T Cells Make Cancer Immunotherapy Safer
Time of Update: 2022-08-15
"For solid tumorsWhen the researchers tested the ability of SNIP CAR-T cells to fight solid cancers in mice, they found that they were more effective than traditional CAR-T therapy -- in many cases, they cured patients with brain cancer called adult cancer.
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New strategy for the treatment of aggressive brain cancer glioblastoma
Time of Update: 2022-08-15
bifunctional mesenchymal stem cellsGiven the critical and very limited timeline from diagnosis to initial surgical intervention in GBM patients, allogeneic "off-the-shelf" engineered stem cells offer a promising therapeutic strategy for targeting residual GBM after surgery .
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"Nature" infected with new crown Omicron acquired weak "natural immunity"
Time of Update: 2022-08-15
" SARS-CoV-2 infection in unvaccinated people, according to a new study published today in the journal Nature, by researchers at the Gladstone Institute and the University of California, San Francisco (UCSF) Omicron variants provide little long-term immunity to other variants .
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Miao Peng's research group from Suzhou Institute of Medical Technology has made progress in the construction of fluorescent logic gates based on silver nanoclusters
Time of Update: 2022-08-15
Confocal images of logic gates in HeLa cells after sequential addition of graphene oxide @AgNCs , auxiliary chains and telomerase inhibitors Telomerase, a ribonucleoprotein complex containing an endogenous RNA template that catalyzes DNA elongation , is upregulated in most human cancers and is an important tumor marker .
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Etiological research and epidemic transmission risk investigation of tick-borne flavivirus Karshi virus
Time of Update: 2022-08-15
In this study, a new strain of KSIV was isolated by inoculation of suckling mice and cell culture, which was derived from Hy. asiaticum collected from Wujiaqu, Xinjiang in 2016 , belonging to the family Flaviviridae (family Flaviviridae ) flavivirus Tick-borne encephalitis virus serocomplex (TBEV serocomplex) of the genus Flavivirus , evolutionarily related to TBEV .
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"Nature Communications" advises middle-aged people to eat less protein
Time of Update: 2022-08-15
A new study from the Pennington Center for Biomedical Research, recently published in the journal Nature Communications, found that reducing the amount of protein in the diet produces a range of beneficial health outcomes, including increased longevity, that depend on a source of protein from the liver.
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[Red Net] The Wugang scientific research project of Academician Liu Shaojun's team has achieved initial results. More than 8 million new species of fry have been successfully cultivated
Time of Update: 2022-08-15
html From April to June every year, fish spawn The broodstock are salvaged from the bream parent pond to prepare for cultivating fry .
html From April to June every year, fish spawn The broodstock are salvaged from the bream parent pond to prepare for cultivating fry .
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[China Science and Technology Network] New breakthrough in corn breeding!
Time of Update: 2022-08-15
The genotype-independent maize genetic transformation technology can achieve genetic transformation or gene editing for most of the maize backbone inbred lines to meet the needs of future maize biological breeding Xu Jieting, the first author of this article, an on-the-job doctoral student at Huazhong Agricultural University and the technical director of Weimi Biotechnology (Jiangsu) Co.
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Break history!
Time of Update: 2022-08-15
image: Schematic illustration of the preparation of bilayer structures of various sizes and shapes by applying an electric field to the upper and lower layers of the substrate to control the concentr
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HPV cancer vaccine teamed up with blockbuster PD-L1 antibody to treat advanced cervical cancer and achieve 64% disease control rate
Time of Update: 2022-08-15
16 in combination with the PD-L1 inhibitor atezolizumab in patients with human papillomavirus 16 (HPV16)-positive advanced cervical cancer Nykode Therapeutics (Nykode) announced positive results from a Phase 2 clinical trial of its therapeutic cancer vaccine VB10.
Retrieved May 12, 2022 from https:// 2022/05/09/2438179/0/en/Nykode-Therapeutics-announces-positive-interim-results-from-its-Phase-2-trial-with-VB10-16-in-combination-with-immune-checkpoint- inhibitor-atezolizumab-in-advanced-cervical-cancer.
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Clues to mitochondrial aging
Time of Update: 2022-08-15
"Now that we have different hypotheses about why mitochondrial dysfunction occurs in aging and age-related diseases, we open up a completely different way of thinking about, measuring, mitigating and reversing this process," Chuankai ( Said Dr. Kai) Zhou , senior author of a study published March 2 in the journal eLifeMitochondria are often referred to as the cell's "powerhouse" because this bean-like structure provides the unit of energy each cell needs to function .
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Wuhan Botanical Garden "Agrobacterium rhizogenes-mediated stable transformation method of peach root system and its application" was authorized by the national invention patent
Time of Update: 2022-08-15
In response to the above problems, researcher Han Yuepeng from Wuhan Botanical Garden's Fruit Tree Molecular and Breeding Division invented "a method for stable transformation of peach roots mediated by Agrobacterium rhizogenes and its application" .
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Sea ice controls stability of Antarctic ice sheet, new study finds
Time of Update: 2022-08-15
In the absence of atmospheric and ocean warming over the past 20 years, the main controlling factor is changes in wind patterns in the Weddell Sea region, which push sea ice against ice shelves So what is causing the ice shelves to advance?
