Etiological research and epidemic transmission risk investigation of tick-borne flavivirus Karshi virus

Xinjiang Uygur Autonomous Region is located in the northwest of Chi.

On May 3, 2022, the international academic journal Frontiersin Microbiology published online the latest research paper completed by the Wuhan Institute of Virology, Chinese Academy of Sciences/National Virus Resource Bank Deng Fei/Shen Shu team, Xinjiang University Sun Surong team and the University of Liverpool Tick Cell Bank , the title of the article is "Discovery of Tick-Borne Karshi Virus Implies Misinterpretation of the Tick-Borne Encephalitis Virus Seroprevalence in Northwest China" (the discovery of tick-borne virus KSIV suggests that the previously higher antiserum levels of tick-borne encephalitis virus in northwest China may misunderstandin.

In this study, a new strain of KSIV was isolated by inoculation of suckling mice and cell culture, which was derived from .

Since KSIV is evolutionarily related to TBEV, there may be a serological association between the t.

Bai Yuan, a doctoral student of Wuhan Institute of Virology, is the first author of the paper, and researcher Fei Deng, young researcher Shen Shu and professor Sun Surong of Xinjiang University are co-corresponding authors of the pap.

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FigureIsolation, identification and morphological characteristics of KSIV

(A) Immunofluorescence detection of KSIV continuous passage and expansion in BHK-21 cells; (B) Plaque assay to identify KSIV infectivity; (C) Electron microscope to observe KSIV particle morphology; (D) Electron microscope to observe KSIV in infected BHK-21 cells positioning