-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Scientists from Saudi Arabia's Salk Institute and King Abdullah University of Science and Technology (KAUST) have discovered that a stretch of DNA that jumps around the human genome plays a role in progeria
"These findings provide new insights into progeria-like syndromes and their treatments, while also highlighting the importance of LINE-1 RNA in normal aging," said Salk Professor in the Gene Expression Laboratory, Altos Laboratory at the San Diego Institute of Science Director and co-corresponding author Juan Carlos Izpisua Belmonte said
Progeria-like syndromes, including Hutchinson-Gilford progeria syndrome and Werner syndrome, can cause accelerated aging in children and adolescents
One of the molecular features of normal aging and progeria-like syndromes is the overall organization of DNA
The team then developed molecules that specifically bind to LINE-1, preventing the RNA from accumulating and affecting cells
Roger Guillemin Chair Izpisua Belmonte said: "Targeting LINE-1 RNA may be an effective approach for the treatment of Progeria-like syndrome and other age-related diseases associated with LINE-I, including neuropsychiatric disorders, ocular diseases, metabolic disorders and cancer
The researchers are planning future studies to better understand what causes the accumulation of LINE-1 RNA and how it can be prevented with drugs in human patients
