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Researchers in the UConn Department of Biomedical Engineering have developed a new cardiac cell-derived platform that closely mimics the human heart, unlocking the potential for more thorough preclinical drug development and testing, and modeling heart disease
The study, published in Cell Reports by Assistant Professor Kshitiz in collaboration with Dr.
"The need to make human heart devices for various applications is very strong
Kshitiz and Afzal first discovered the need to create mature human heart tissue while working together at the Johns Hopkins School of Medicine
Cardiovascular safety is the leading cause of failure in preclinical drug development, and the establishment of human cardiac tissue models to test the cardiotoxicity of drugs has long been required
Afzal said: "When the method of differentiating human pluripotent stem cells into heart cells is developed, it gives us great hope that we will eventually have human heart structures to study
In this study, the researchers exploited the cardiac biology of the adult human heart to rapidly mature differentiated cardiomyocytes into a more adult-like state
The researchers are optimistic that this application will not only be used for preclinical drug testing, but also for future precise disease modeling to study disease mechanisms and test regenerative therapies
Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes
