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Researchers at McKelvey College of Engineering and School of Medicine have invented a technique that shows them how kidney changes linked to diabetes and elevated blood sugar affect the mechanical function and resilience of podocytes, which has the potential to find new treatments
Chronic kidney disease and eventual kidney failure are incurable diseases that affect 13 percent of the U.
Finding effective treatments has been hampered because these highly structured cells cannot be cultured in vitro and the structure of immortal cell lines does not match
The discovery, published Aug.
"We now have a window into the dynamics of cytoskeletal dynamics of shape changes and cell loss in injury and disease," said Dr.
A podocyte is a unique type of cell with a hierarchical structure, including the almost octopus-like tentacles
"We've never been able to see how these structures react to stress in real time before," Miner said
"An exciting new perspective is the ability to study and manipulate the mechanobiological aspects of cell responses to disease," said
The University of Washington has filed a patent application for the technology in partnership with the university's Office of Technology Management, and the team hopes to use the system to conduct a series of studies and ultimately a treatment
"Now we can test human cells from diseased kidneys, we can quickly screen for chemotherapy that affect protein kinetics and mechanobiology, and begin to gradually treat a range of diseases
