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Spear and Shield of Actinomycetes: Resisting Self-produced Antibiotics New Discovery Reveals N-succinyltransferase can inactivate a variety of antibiotics, but it is hidden in the cryptographic siderophore BGC!
Time of Update: 2022-09-07
Antibiotics are secondary metabolites (SMs) produced by certain bacteria and fungi that are not necessary for growth, development or reproduction, but in the natural environment they provide an advantage in competing for nutrients or defending against predators .
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Chinese Academy of Sciences scholars reveal the unique evolutionary path of CRISPR guard RNA
Time of Update: 2022-09-07
1093/nar/gkac712/6677323 The research team of Xiang Hua/Li Ming from the Institute of Microbiology, Chinese Academy of Sciences previously discovered a new class of dual RNA-type toxin-antitoxin system CreTA that can protect CRISPR-Cas (Science, 2021).
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Science: A treatment that could improve cognitive function in people with Down syndrome
Time of Update: 2022-09-07
abq4515 Down syndrome, also known as trisomy 21, affects one in 800 births and causes a variety of clinical manifestations, including cognitive decline .
abq4515 Down syndrome, also known as trisomy 21, affects one in 800 births and causes a variety of clinical manifestations, including cognitive decline .
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A protein acts at the control center of cancer cells to stop cancer from spreading
Time of Update: 2022-09-07
"article titleNucleofugin regulates cancer cell survival This study sheds light on an important pathway by which glutin promotes cancer development and provides insights into potential pathways to block its effects .
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Rhythmicity of gut IgA responses provides oscillating symbiotic microbiota reciprocity
Time of Update: 2022-09-07
Gut microbes surf the IgA cycleIgA is the predominant immunoglobulin class on the mucosal surface and supports host microbiota interactions by regulating the composition and function of the gut microbiota .
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Hu Youfan's group from the School of Electronics has made important progress in the study of epidermal electronic systems
Time of Update: 2022-09-07
Recently, Hu Youfan's research group from the School of Electronics, Peking University and the Key Laboratory of Nanodevice Physics and Chemistry of the Ministry of Education used carbon nanotube network films as semiconductor materials to construct an integrated epidermal electronic system including flexible sensors, sensing interface circuits and storage arrays .
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The relationship between aggressive prostate cancer and human genetics
Time of Update: 2022-09-07
Genome Medicine, 2022; 14 (1)Tingting Gong, Weerachai Jaratlerdsiri, Jue Jiang, Cali Willet, Tracy Chew, Sean M.
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The research group of Academician Lu Lin of Peking University reveals the long-term physical and mental system sequelae after the new crown epidemic
Time of Update: 2022-09-07
Subgroup analysis of COVID-19 sequelae according to follow-up time, severity and other factors Long-term mental and neurological symptoms of new crown recovered patientsAmong the sequelae of long-term psychiatric symptoms of COVID-19 recovered patients (Figure 2), the reported rate of depressive symptoms was 18.
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How microbial communities "exchange knowledge"
Time of Update: 2022-09-07
”Horizontal Gene Transfer Enables Programmable Gene Stability in Synthetic Microbiota Linchong You is a professor of biomedical engineering at Duke University Biomedical engineers at Duke University demonstrated a microbial community phenomenon that essentially equates to teaching neighbors how to accomplish necessary tasks by removing and sharing a part of the brain.
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The cells also involute!
Time of Update: 2022-09-07
The Heber Youth Program is based on the existing aging intervention technology, carries out corresponding real-world research, and forms a systematic anti-aging solution to achieve the reversal of physiological age, so that people in their 60s can still have the vitality of 30 years old .
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The South China Botanical Garden reveals the physiological characteristics and response strategies of four subtropical tree species under drought treatment
Time of Update: 2022-09-07
The research team of Liu Juxiu at Dinghushan Station of the South China Botanical Garden of the Chinese Academy of Sciences focused on four common tree species in subtropical plantation forests ( hainan red bean - Ormosia pinnata , Dalbergia odorifera , C.
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Genome-wide in vivo screening of circulating tumor cells identified SLIT2 as a regulator of metastasis
Time of Update: 2022-09-07
Opens in the viewerFor sgRNA enrichment analysis, we first analyzed the TKOv3 library depletion of the original CRISPR-edited PC-3M cells, primary tumors, and isolated CTCs. Most of the sgRNAs from the library were significantly reduced or not expressed in isolated CTC samples compared to sgRNA counts in the PC-3M cell pool before injection (Figures 1, C, and D).
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Wuhan Institute of Virology/State Key Laboratory of Virology has made new progress in the study of echovirus infection-induced pyroptosis mechanism
Time of Update: 2022-09-07
ECHO11 nonstructural protein 2B induces NLRP3 inflammasome-dependent pyroptosis In August 2022, the international academic journal PLOS Pathogens published online the latest results of the team of researcher Zhou Xi from Wuhan Institute of Virology/State Key Laboratory of Virology, Chinese Academy of Sciences.
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Liquid biopsy predicts neurotoxic complications of CAR-T cell therapy
Time of Update: 2022-09-07
The researchers analyzed blood samples from patients before, during and after CAR-T cell therapy and found higher levels of a protein called neurofilament light chain (NfL) in patients who developed neurotoxic complications .
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New study confirms 'ripple sheet' protein structure predicted in 1953
Time of Update: 2022-09-07
Figure: Ripple betas are variants of ruffled betas, a well-known structural motif found in thousands of proteins .
Raskatov Figure: Ripple betas are variants of ruffled betas, a well-known structural motif found in thousands of proteins .
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Research progress on aboveground and subsurface traits of tree species
Time of Update: 2022-09-07
seedlings (Apohananthe cuspidataBreynia fruticosaMacaranga denticulataMallotus barbatusSapium baccatum The research results, titled Above and belowground plant traits are not consistent in response to drought and competition treatments, were published in Annals of Botany, a major journal of botany 。 Dr. Asefa Mengesha, a postdoctoral fellow from the Forest Ecosystem Structure, Function and Dynamics Research Group, is the first author of the paper, and the co-supervisor, Researcher Yang Jie, is the corresponding author of the paper.
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Metformin prevents age-related ovarian fibrosis by modulating the immune landscape of female mice
Time of Update: 2022-09-07
We show that metformin treatment regulates immune cells to form a unique subset of macrophages and prevents the formation of age-related ovarian fibrosis, which may maintain intra-tissue homeostasis by promoting extracellular matrix remodeling and scavenging SASP-producing fibroblasts.
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How breast cancer cells open tissue channels
Time of Update: 2022-09-07
Nano Letters, 2022 Now, researchers have developed a new method of 3D culture to accurately quantify how cancer cells generate forces to spread within tissues .
Nano Letters, 2022 Now, researchers have developed a new method of 3D culture to accurately quantify how cancer cells generate forces to spread within tissues .
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PNAS: Effects of fentanyl on the brain
Time of Update: 2022-09-07
key takeawayElectroencephalogram (EEG) tests showed fentanyl's effects on the brain and showed that the drug stops breathing before people experience other noticeable changes and lose consciousness .
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Where and why proteins malfunction in Parkinson's disease
Time of Update: 2022-09-07
Scientists from the Francis Crick Institute at UCL and the University of Edinburgh have discovered how a harmful protein starts to build up in neurons in Parkinson's disease, eventually causing the nerve cells to die .
