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Figure: On this computed tomography, tumors (yellow) are spread across the lungs (left) of mice that are genetically predisposed to small cell lung cancer
Image credit: Simone Hausmann and Pawel Mazur
According to a study in mice conducted by researchers at Washington University School of Medicine in St.
One of the drugs, cyclophosphamide, is an outdated chemotherapy drug that was once used to treat small cell lung cancer
In this study, however, the researchers showed that small cell lung cancer cells fight cyclophosphamide by activating a specific repair process, and demonstrated that disrupting the repair process makes the drug more effective, at least in mice
"There is a treatment option for small cell lung cancer — platinum-based chemotherapy — which could add 2 to 6 months of life," said co-author Nima Mosammamaparast, associate professor of pathology, immunology and medicine at the University of Washington and a fellow at
The study was done by accident
The team found that RNF113A is regulated by a protein called SMYD3, which is highly expressed
So they tried
All the mice had tumors
Mosammaparast said: "We are in discussions with a number of other organizations to start Phase I clinical trials
