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A team including Rutgers scientists has engineered a synthetic protein that can rapidly detect the molecules of a deadly nerve agent that has been classified by the United Nations as a weapon of mass destruction for use in chemical warfare attack
As described in the journal Science Advances, the team made the protein by special design on a high-speed computer in the Rutgers lab
VX is an odorless, tasteless man-made compound that is the most toxic and most reactive of all known chemical warfare agents
The Rutgers team engineered the protein to have a cavity in its center that matches the precise shape and chemical composition of VX
"The protein undergoes a massive shape change, burying the VX in the cavity we designed," said Nanda, who is also a professor of biochemistry and molecular biology at Rutgers University's Robert Wood Johnson School of Medicine
The protein can detect VX 1,000 times more sensitively than existing technologies, Nanda said
According to the US Centers for Disease Control and Prevention's website, VX or other nerve agents may have been used in chemical warfare during the Iran-Iraq war in the 1980s
"The design approach presented here should enable the development of a new generation of biosensors, therapeutics and diagnostics," Nanda said
Computational design of a sensitive, selective phase-changing sensor protein for the VX nerve agent
