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On September 2, 2022, the team of Luo Donggen from the Academy of Sciences of Peking University, the McGovern Institute for Brain Research, the Center for Quantitative Biology, and the Joint Center for Life Sciences published a research paper on "An extra-clock ultradian brain oscillator sustains circadian timekeeping" in Science Advances, reported A novel electrical signal and its neural mechanism for maintaining circadian rhythm
The circadian rhythm is coordinated and controlled by the brain's main biological clock, and its core is the negative feedback between the biological clock genes and their proteins to generate a molecular rhythm with a cycle of 24 hours (winning the 2017 Nobel Prize in Physiology or Medicine)
For the first time, Luo Donggen's team developed a method to record the fine electrical activity of all Drosophila clock neurons ( 3 ) .
Figure 1: Maintenance of circadian rhythms by xCEOs
The study identified the first population of oscillatory neurons in the Drosophila brain and revealed its neural mechanism in maintaining circadian rhythms (Figure 1)
Researcher Luo Donggen is the corresponding author of this article; Dr.
Original link: https://doi.
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