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Astrocytes feed glioblastoma and promote tumor growth
Time of Update: 2022-10-12
In the new study, researchers at Tel Aviv University demonstrated that astrocytes do support glioma after its initial onset of pathogenesis, both by remodeling immune cells to support tumor growth and by providing the tumor with enough cholesterol to maintain its survival.
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Nature Sub-Journal: New Insights into Tumor Biology
Time of Update: 2022-10-12
The cluster of cancer cells in the tumor forms a new state of matter in which only a few solid islands of hard cells in the fluid environment of soft cells are sufficient for the tissue to behave as mechanically stable solid rather than liquid, although most moving soft cancer cells are mobile.
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Melanin Protection: Exposure to nuclear radiation to black frogs reveals the role of evolution
Time of Update: 2022-10-12
The color of the tree frogAfter detecting the first black frogs in 2016, we decided to study the role of melanin in Chernobyl's wildlife.
The color of the tree frogAfter detecting the first black frogs in 2016, we decided to study the role of melanin in Chernobyl's wildlife.
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The Institute of Nutrition and Health traced the ancient Baiyue population by analyzing the genetic data of the Li ethnic group in Hainan
Time of Update: 2022-10-12
On September 30, 2022, Molecular Biology and Evolution, a well-known international journal in the field of molecular evolution, published the research results of the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences "Tracing Bai-Yue ancestry in aboriginal Li people on Hainan Island" 。 Based on whole-genome sequencing data analysis, the research team studied the genetic origin, population history and adaptive evolution of the Li (HNL) in Hainan.
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University of Science and Technology of China: A new mechanism for genome stability to regulate apical kinase ATR activation
Time of Update: 2022-10-12
Written by: Zhang QingjunOriginal link: Professor Xuejuan Wang and Professor Gang Cai of the University of Science and Technology of China used single-particle cryo-EM technology to analyze the structure of endogenous activation of ATR kinase in Saccharomyces cerevisiae cells, and revealed a new mechanism of activation of this kinase.
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Nature Genetics: Your genes determine whether you have ADHD or autism
Time of Update: 2022-10-12
essayIdentification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups Image: Professor Anders Börglum leads a study that provides a new biological basis for the development of autism and ADHD (or just one of the diagnoses).
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Nature Sub-Journal: A big advance in tuberculosis treatment
Time of Update: 2022-10-12
"At the same time, the researchers discovered a new antibiotic, evybactin, a DNA rotational enzyme inhibitor, and they demonstrated that it only targets Mycobacterium tuberculosis.
"At the same time, the researchers discovered a new antibiotic, evybactin, a DNA rotational enzyme inhibitor, and they demonstrated that it only targets Mycobacterium tuberculosis.
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Nature first revealed that T cells signal to the immune system to stop attacking cells in the intestinal mucosa
Time of Update: 2022-10-12
Article Manuscript title: γδ IEL effector API5 masks genetic susceptibility to Paneth cell death A new study may have solved a mystery about Crohn's disease.
Article Manuscript title: γδ IEL effector API5 masks genetic susceptibility to Paneth cell death A new study may have solved a mystery about Crohn's disease.
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Gene localization and functional analysis of candidate genes for important agronomic traits in rapeseed
Time of Update: 2022-10-12
" In the research paper, the study revealed the genetic regulation mechanism of sulfur glycoside accumulation in cabbage-type rapeseed by jointly analyzing the QTL localization of multi-environment thioside QTL and the gene expression profile of seeds and leaves of high and low thioside content, and provided more profound insights for further reducing the seed glucosinolate content (SGC).
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"Game changer": a new technology that simulates molecular life with computers
Time of Update: 2022-10-12
According to first author Ilya Vakser, director of the Computational Biology Program and Center for Computational Biology and professor of molecular biology sciences at the University of Kansas, the study of computer modeling of life processes is an important step in creating simulations of the work of living cells at atomic resolution.
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The tumor microbiome finds new ways to treat pancreatic cancer
Time of Update: 2022-10-12
Researchers from the Rutgers Cancer Institute of New Jersey, the state's leading cancer center and the only National Cancer Institute-designated comprehensive cancer center, examined pancreatic tumors' microbiomes and identified specific microbes associated with inflammation and low survival rates in single-cell resolution.
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Chinese scholars and overseas collaborators have made progress in the study of mass extinction at the end of the Permian
Time of Update: 2022-10-12
Figure Evolution of atmospheric carbon dioxide concentrations and paleomarine primary productivity community structures during the late Permian mass extinction based on biomarker compound monomer iso
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Environ Sci Technol School of Public Health Wang Hui's team analyzes long-term low-dose exposure to heavy metals...
Time of Update: 2022-10-12
The study used bacterial models to carry out mutation accumulation experiments, and comprehensively analyzed the specific genetic variants and adaptive mutation characteristics caused by the long-term continuous exposure of low doses of six different heavy metals by using whole-genome sequencing technology, which increased the understanding of the mutagenicity toxicity of heavy metal exposure, and provided important support for assessing their environmental toxicity hazards and formulating relevant policies.
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Human cocaine and heroin addiction is associated with damage to specific brain circuits in animals
Time of Update: 2022-10-12
The results highlight the potential specificity of the apparent prefrontal cortex connection to the neuropathology of drug addiction Source: Mount Sinai Health SystemA study conducted by researchers at the Icahn School of Medicine at Mount Sinai and Baylor College of Medicine showed that the brain's white matter, previously involved in animal studies, is now thought to be particularly impaired in the brains of cocaine or heroin addicts.
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Nature Immunology Li Huabing research group and cooperation team reported that tRNA-m1A modification is CD4+T fine...
Time of Update: 2022-10-12
Wilson Distinguished Service Professor, Department of Chemistry,University of Chicago Investigator, Howard Hughes Medical Institute Li Huabing's team has been focusing on the study of the impact of RNA modification on immune cell development and function, especially on the exploration of the epigenetic regulation of T cell RNA, and published a series of high-level research results, which has formed a certain academic influence.
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Yi Chengqi and collaborators in the School of Life Sciences report a new mechanism by which tRNA-m1A modification regulates the function of CD4+ T cells
Time of Update: 2022-10-12
TRMT61A-mediated tRNA-m1A58 modification is a "translation checkpoint" for CD4+ T cell activation and proliferation regulationDr. Liu Yongbo, Associate Researcher Zhou Jing and Master Candidate Shi Jintong of Shanghai Jiao Tong University School of Medicine, Xiaoyu Li (now a researcher at Zhejiang University School of Medicine) and doctoral student Zhang Xiaoting of the School of Life Sciences of Peking University are the co-first authors of this paper, and Li Huabing, Yi Chengqi, Wu Yuzhang and Richard A.
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Long-term sequelae of COVID-19 may stem from an overactive immune response in the lungs
Time of Update: 2022-10-12
The role of the immune system in chronic diseasesIn Harish Narasimhan's study, many different types of immune cells are involved in the development of chronic diseases following respiratory viral infections, including long COVID-19.
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$2 million: Intestinal capsules-microbiota as drugs
Time of Update: 2022-10-12
What happens if we can photograph our microbiome when we're healthy and then use it to reset our bodies when we're sick?This potential is the driving force behind the research conducted by Tagbo Niepa, an assistant professor of chemical engineering at the University of Pittsburgh.
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Immunity: Cells play "molecular roulette" to decide how the body fights disease
Time of Update: 2022-10-12
The study, led by researchers at WEHI in Melbourne, Australia, suggests that the cells responsible for making antibody proteins use a random process to decide which type of antibody to make, a behavior scientists call "molecular roulette.
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New genetic variants from ancient and exotic varieties can be used for environmentally friendly wheat cultivation
Time of Update: 2022-10-12
Thanks to continuous funding of this work by the Federal Ministry of Education and Research for 6 years, the yield performance and resistance to yellow rust of a large number of old wheat varieties collected by the IPK Leibniz Institute have been tested in laboratory and field trials.
