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On September 22, 2022, the team of Li Huabing, a researcher at Shanghai Jiao Tong University School of Medicine, Professor Yi Chengqi at the School of Life Sciences of Peking University, Professor Wu Yuzhang of the Army Military Medical University, and Professor Richard A.
Screenshot of the paper
T cells play a central role
tRNAs play an important role
The study first observed that protein translation-related pathways are regulated during T cell activation, and different tRNAs also show dynamic expression patterns of upregulation at differenttime points, and the tRNA-m1A58 modifier enzyme TRMT6/TRMT61A is also upregulated
The authors then explore the specificity
This study is the first to link tRNA modifications to functional changes in T cells, and systematically explores the specific mechanisms that control translation during primary T cell amplification, showing that the use of tRNA and its modifications can bring significant changes
TRMT61A-mediated tRNA-m1A58 modification is a "translation checkpoint" for CD4+ T cell activation and proliferation regulation
Dr.
References:
1.
2．Liu, F.
3.
