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Image: Using diffuse MRI beam imaging, the structural connection
Source: Mount Sinai Health System
A study conducted by researchers at the Icahn School of Medicine at Mount Sinai and Baylor College of Medicine showed that the brain's white matter, previously involved in animal studies, is now thought to be particularly impaired
The study looked at the connections between the prefrontal cortex (PFC), a key brain region that regulates higher-order executive function, and the habenula, which plays a key role
Dr.
"In addition to identifying differences in microstructure, particularly in the cocaine addiction group that includes current cocaine users and short-term abstinents, the consistency of the white matter fiber direction decreases, and we extended the results from cocaine (a stimulant) to heroin (an opioid), suggesting that abnormalities in this pathway may be pervasive
The results of the study give impetus to ongoing research in the field that targets a previously unexplored circuit in the pathophysiology of human addiction in which defects may predispose a person toward the development and recurrence of drug addiction, which may be appropriate for an individual's tailored treatment or prevention effort
Prefrontal-habenular microstructural impairments in human cocaine and heroin addiction
