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Immunity: Cells play "molecular roulette" to decide how the body fights disease

 Last Update: 2022-10-12
 Source: Internet
 Author: User

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Figure: B cells (lime-green) produce antibodies (black

A new discovery about how cells produce antibodies reveals a surprisingly random way

summary

Studies have shown that B cells use a randomization process
The discovery, led by Wehi, reveals the first mathematical model
This landmark discovery could lead to future research that could prevent this process from being interrupted and lead to disease, while bringing the field significantly closer to using quantitative data to map the behavior of the

Antibodies are produced by immune cells and protect our bodies from disease by alerting the immune system to foreign invaders, such as pathogens and viruses

Critical predictions

Leveraging the mathematical expertise of international peers and WEHI's single-cell technology, the team created a formula to better understand the B-cell allocation process

essay

Lineage tracing reveals B cell antibody class switching is stochastic, cell-autonomous, and tuneable

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