-
The brain in the brain: when human neurons are transplanted into animal brains Nature long article
Time of Update: 2023-02-03
Scientists transplanted human organoids (bright green) into mouse brains to study the cellular behavior of neuronal cells in the context of health and disease.
Scientists transplanted human organoids (bright green) into mouse brains to study the cellular behavior of neuronal cells in the context of health and disease.
-
Cold Spring Harbor Laboratory reveals the mechanism of glioma, bringing new hope for the treatment of malignant brain tumors!
Time of Update: 2023-02-03
Scan the QR code below or click to read the original article to view more oncology information without downloadingThis study identified the mechanism by which BRD8 protein regulates P53 gene activity in GBM, which may provide an effective strategy for the treatment of P53WT GBM.
-
【Cell Research】The latest research by Shi Yigong's team reveals the cause of the strongest risk factor for Alzheimer's disease
Time of Update: 2023-02-03
Referrals, live broadcasts/events01/12 14:00-16:00 OnlineOlink Multiomics Cohort ForumScan the code to participate for free03/02-03 09:00-18:00 ShanghaiThe 2nd Yangtze River Delta Single-cell Omics Technology Application ForumScan the code to participate for freeThis article is the original of Translational Medicine Network, please indicate the source for reprintingWritten by JevinApolipoprotein E gene (APOE) product Apolipoprotein E (APOE) plays a key role in lipid metabolism, immunomodulation, and neurology.
-
Science| Synaptic type-specific local protein synthesis regulates cortical junctions
Time of Update: 2023-02-02
1038/ncb840; pmid: 12172554Reprint instructions【Original article】BioArt original article, welcome to share by individuals, reproduction is prohibited without permission, the copyright of all works published is owned by BioArt. BioArt reserves all statutory rights and violators will be prosecuted.
-
From "surviving" to "living well", focus on the quality of life of patients with spinal muscular atrophy (SMA) in China
Time of Update: 2023-02-02
Table 1: HRQoL stratified by (A) SMA disease type and (B) motor function statusEffect of the therapeutic drug Nocinaxen on HRQoLA total of 322 patients were enrolled in the first round of evaluation, including 51 in the drug treatment group.
-
2022 annual inventory: from "neuroprotection" to "brain cell protection", stroke treatment concept is more comprehensive
Time of Update: 2023-02-02
Table 1: Comparison of changes in various indicators before and after treatment▌Basic studies have shown that the mechanism of edaravone dextrol in reducing cerebral ischemic injury is related to the upregulation of MKP-1 expressionProfessor Du Guanhua's team of Peking Union Medical College Hospital used a rat model of four-vessel occlusion (4-VO) to observe the efficacy of edaravone dextrol and explore the specific mechanism of action, and the results were officially published in BioMed Research International in September 22 [9].
-
The new crown causes nerve problems! Academician Bian Xiuwu and other teams have revealed the underlying mechanism of neurological symptoms caused by the new coronavirus
Time of Update: 2023-02-02
Structural damage and molecular alterations of the blood-brain barrier (BBB) in the brain of COVID-19Research significance 03 03 The study identified the molecular signature of COVID-19-associated encephalitis with monocytes infiltration and glial cell activation through systematic pathological and proteomic analysis of the COVID-19 autopsy brain.
-
What are the characteristics of Guillain-Barré syndrome associated with the new crown vaccine?
Time of Update: 2023-02-02
However, there have also been reports of neurological adverse reactions after vaccination, including Guillain-Barre Syndrome (GBS) and immune thrombosis, which have caused alarm among health authorities in various countries.
-
Nat Methods Tian He et al. reported the optimization of far-infrared membrane potential probes based on optical hybrid screening technology
Time of Update: 2023-02-02
In the optical screening process, the authors first measured the membrane potential probe signals of thousands of mutant library cells in the imaging field of view, and used a digital micromirror array device (DMD) to accurately project violet light onto cells with both brightness and responsiveness.
-
Nature Aging: Zeng Jianxiong et al. of the Chinese Academy of Sciences discovered the key mechanism of innate immune cGAS-STING pathway activation and inhibition of the pathogenesis of Alzheimer's disease
Time of Update: 2023-02-02
Information: style="margin-right: auto;margin-left: auto;outline: 0px;width: 30px;display: inline-block;">—END—The content is [iNature]iNatureCICL GMP SATASE (CGAS) DETECTS MICROBIAL AND HOST-DERIVED DOUBLE-STRANDED DNA IN THE CYTOPLASM TO TRIGGER CELLULAR INNATE IMMUNE RESPONSES IN A STIMULATOR OF INTERFERON GENES (STING)-DEPENDENT MANNER.
-
Lewy body dementia, two major clinical drug treatment directions!
Time of Update: 2023-02-02
👇Download the Decision Assistant App, the guide is free at any time~▼▼▼Click to read the original article to download the AppFor medical professionals onlyFor more guidelines for the diagnosis and treatment of common neurological diseases, go to the "Clinical Decision Assistant App"!
-
Not only coffee milk spots, read neurofibromas in one article
Time of Update: 2023-02-02
*For medical professionals onlyNeurofibromatosis, although rare, should not be taken lightly. Neurofibromatosis type I (NF1) is an autosomal dominant genetic disease [1], which can cause damage and dy
-
After 6 years, the guidelines for the treatment of nerve repair for idiopathic facial palsy have been updated and the key points are quick to see
Time of Update: 2023-02-02
*For medical professionals onlyAttached 5 major evaluation scales, collect quickly!Idiopathic facial nerve palsy, also known as facial neuritis, Bell's palsy, traditional Chinese medicine called mouth seclusion, mouth and eye skew, is the most common facial nerve disease, accounting for 60% ~ 75%, the incidence is (11.
-
People with this blood type seem more likely to have a stroke before age 60?
Time of Update: 2023-02-02
Click "Read Original" to get more clinical dry goodsmeta-analysis of genome-wide association studies of EOS aged 18-59 years, researchers obtained 16,730 cases and 599237 stroke-free controls in 48 different studies, using individual-level data or pooled statistics.
-
Science: Rewrite the textbook! For the first time, scientists have discovered that there may be a fourth layer of meninges in the human brain!
Time of Update: 2023-02-02
From this, the researchers concluded that SLYM is a layer 4 meningeal structure that surrounds the mouse and human brains, differs immunophenotypically from dura mater, arachnoid and pia mater, and exhibits lymphoid features (Prox1-EGFP+, PDPN+, LYVE1-, CRABP2+, VEGFR3).
-
Science—Heavy! A history of obesity induces epigenetic changes in the innate immune system and exacerbates neuroinflammation
Time of Update: 2023-02-01
Written by Jane Cheng – Wang Sizhen, Fang Yiyi edited – Wang Sizhen age-related macular degeneration （age-related macular degeneration， AMD) is a neuroinflammatory disease that is influenced by geneti
-
Learning ability is not comparable to that of elementary school students? Yes, because of this chemical in the brain!
Time of Update: 2023-02-01
Figure 1 Research results (Source: [1])Effective learning means being able to learn more content in a given amount of time, which requires learners to quickly consolidate the learning content after training, that is, stabilize the fragile and malleable learning state after training into a solid memory that is not disturbed by new learning content.
-
Express In view of the common genetic risk of Parkinson's disease, Xinrui has reached a gene therapy cooperation
Time of Update: 2023-02-01
▲If you have any business needs, please press and hold to scan the QR code above, or▎WuXi AppTec content team editorNeurocrine Biosciences and Voyager Therapeutics today announced a new strategic collaboration to advance multiple gene therapies for the treatment of neurological disorders.
-
Heavy! The Institute of Chemistry of the Chinese Academy of Sciences today Science can simulate brain communication!
Time of Update: 2023-02-01
Here, researchers Mao Lanqun and Yu Ping of the Institute of Chemistry, Chinese Academy of Sciences, successfully realized neuromorphic functions using polyelectrolyte-confined fluid memristors (PFMs), in which confined polyelectrolyte-ion interactions help lag ion transport, thereby producing ion memory effects.
-
Science sub-journal: AAV delivers micro-DMD gene, treatment of DMD golden retriever models
Time of Update: 2023-02-01
Link: style="color: rgb(136, 136, 136);font-size: 12px;letter-spacing: normal;" _mstmutation="1" _istranslated="1"> Open reprint, welcome to forward to Moments and WeChat groups Written byWang Cong EditorWang Duoyu TypesettingShui Chengwen Duchenne muscular dystrophy (DMD) is a single-gene disease with a relatively high incidence, Mutations in the gene encoding dystrophin on the X chromosome, resulting in the inability to produce enough dystrophin, the patient's muscle tissue is gradually replaced by fat and fibrotic tissue, and about 1 in 5,000 newborn male babies is affected.
