-
Science: A big breakthrough! The Duyang team of Hong Kong Zhongda and others discovered a new type of non-addictive non-opioid painkiller
Time of Update: 2023-01-05
2A2A9087 and its analogues 7075 and PS75 are partial agonists of Gi, compared with known α2AAR agonists such as NorEpi, dex, and clon used in experiments, most of the screened new molecules can specifically activate the Gi, Go and Gz pathways, and the recruitment effect on β-inhibitory proteins is negligible at effective concentrations (except 0172), and there is no receptor internalization.
-
What are new options for the treatment of generalized myasthenia gravis in adolescents? 2022 AANEM Essence Hot Review No. 4
Time of Update: 2023-01-05
Generalized myasthenia gravis (gMG) is a rare chronic autoimmune disease that can affect eye movement, swallowing, speech, movement, and respiratory function to varying degrees, severely impairing mob
-
Nat Commun-Liu's team was the first to comprehensively map single-cell cells in the primate visual cortex and found differences in gene expression across species
Time of Update: 2023-01-05
Written by Wei Jiaru, Hao ZhaozheResponsible editor—Wang Sizhen, Fang YiyiEditor—Wang RuhuaThe visual system is the most important sensory system of human beings, perceiving 80% of the sensory informa
-
Alzheimer's Dement—A sword sharpened in ten years! Gu Baijun's team discovered congenital immune-related leukocyte surface antigen markers to help the early hematological diagnosis of Alzheimer's disease
Time of Update: 2023-01-05
Written by - Huangdao Lord, Li Yifan is responsible for editing - Wang Sizhen, Fang Yiyi editing - Xia Leaf Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairmen
-
Express is expected to come out early next year, and myasthenia gravis therapy has been prioritized by the FDA
Time of Update: 2023-01-05
S. Food and Drug Administration (FDA) has accepted its efgartigimod subcutaneous injection formulation for the treatment of adult patients with generalized myasthenia gravis (gMG) and granted priority review status.
-
New discoveries that allow paralyzed people to regain their ability to walk
Time of Update: 2023-01-05
In a study recently published in the journal Nature, an international team of researchers reported that patients paralyzed by spinal cord injury were able to recover some motor function after receiving targeted epidural electrical stimulation (EES) in areas that control leg movement.
-
How to use autoimmune encephalitis in children? Enough to read this!
Time of Update: 2023-01-05
1. Prevention of AE in children has been reported that 14 cases (27%) of AE occurred in 51 patients with herpes simplex virus within 1 month, including 9 cases of anti-NMDAR encephalitis [5]。 Therefore, when the child's condition is doubtful, the relevant antibody test should be given as soon as possible to confirm the diagnosis as soon as possible so that better treatment can be taken and the prognosis should be improved.
-
Dangerous genes that make Thor breathe
Time of Update: 2023-01-05
edu/news/alzheimers-risk-gene-undermines-insulation-brains-wiring#Image source:National Institute on Aging, NIH, Flickr, CC BY-NDJust last week, Chris Hamsworth, also known as "Thor," suddenly announced a temporary retirement.
edu/news/alzheimers-risk-gene-undermines-insulation-brains-wiring#Image source:National Institute on Aging, NIH, Flickr, CC BY-NDJust last week, Chris Hamsworth, also known as "Thor," suddenly announced a temporary retirement.
-
Sudden syncope, how to deal with it? These 7 points to master
Time of Update: 2023-01-05
*For medical professionals only6 key points, collect it quickly!Syncope refers to a transient loss of consciousness caused by transient hypoperfusion of the brain, which is characterized by sudden, transient, transient and complete recovery on its own.
-
Can Alzheimer's really be overcome?
Time of Update: 2023-01-05
Inflammation and metabolismAlthough amyloid remains the focus of many current Phase 3 drug trials, recent research on alternative drug targets for Alzheimer's disease has begun to grow.
-
Nature | pattern regulation of V-ATPase in mammalian brains
Time of Update: 2023-01-05
Figure 2 Working modelIn general, the authors used V-ATPases proton pumps directly purified in mouse brains to unveil their different change patterns at the single-molecule level for the first time V-ATPases proton pumps in mammals can switch from active proton pump mode to inactive or proton leakage mode under pH gradient and ATP substrate adjustment (Figure 2), emphasizing the mechanism and biological importance of neurotransmitter delivery and proton pump mode switching.
-
New breakthrough in brain-computer interface: helping paralyzed patients control wheelchair free movement through thinking
Time of Update: 2023-01-05
Professor Gerwin Schalk, Director of TCCI's Frontiers Laboratory of Applied NeurotechnologyThe mind-controlled wheelchair is an assisted mobility solution based on brain-computer interface technology, especially for people with complete paralysis.
-
Effective in removing toxic proteins! New research brings rare disease mice back to health
Time of Update: 2023-01-05
▎WuXi AppTec content team editor Recently, scientists at the University of Florida have brought new therapeutic hope to patients with amyotrophic lateral sclerosis (ALS) and dementia, and their study, published in the Proceedings of the National Academy of Sciences, introduced a potential drug molecule that can clear the RNA fragments that cause the disease.
-
A 66-year-old female presents with progressive encephalopathy and bilateral hearing loss in clinical reasoning
Time of Update: 2023-01-05
Patients presenting with encephalopathy and acute/subacute hearing loss may be seen in Susac syndrome, intravascular lymphoma, primary central nervous system vasculitis (PACNS), and schwannomas.
Patients presenting with encephalopathy and acute/subacute hearing loss may be seen in Susac syndrome, intravascular lymphoma, primary central nervous system vasculitis (PACNS), and schwannomas.
-
Interview with Professor Xiao Nong and Professor Xu Kaishou: The Expert Consensus on Rehabilitation Management of Spinal Muscular Atrophy was released, leading the standardized SMA rehabilitation management
Time of Update: 2023-01-05
In this context, the Rehabilitation Group of the Pediatrics Branch of the Chinese Medical Association and the Physical Therapy Special Committee of the Chinese Association of Rehabilitation Medicine recently issued the Expert Consensus on the Rehabilitation Management of Spinal Muscular Atrophy to further standardize the rehabilitation assessment and treatment of SMA and give full play to the therapeutic role of rehabilitation combined with DMT drugs.
-
The PNAS-Liu team revealed the important role of connexin hemichannels in alleviating neuroinflammation and overexcitability during the onset of temporal lobe epilepsy
Time of Update: 2023-01-05
Written by—Annie Guo, Junyu LiuResponsible editor—Wang Sizhen, Fang YiyiEditor—Summer LeafEpilepsy is one of the most common neurological disorders and manifests as spontaneous and recurrent seizures.
-
PNAS: breaks through the blood-brain barrier, targets pathogenic RNA, treats ALS and dementia
Time of Update: 2023-01-05
Written byWang Cong EditorWang Duoyu TypesettingWater WritingAmyotrophic lateral sclerosis (ALS), also known as ALS, is one of the five terminal diseases recognized by the World Health Organization (W
-
Nature's power cannot be underestimated! A major breakthrough in the field of single-cell transcriptome in neuroscience
Time of Update: 2023-01-05
His research interests include artificial intelligence, natural language processing, functional genomics, transcriptomics, miRNA and target gene network analysis, single-cell sequencing data analysis, gene regulatory network temporal analysis, protein interaction network analysis, multi-omics joint analysis, etc.
-
Science—The New Gene Therapy! For disorders caused by abnormal activity of brain circuits in the case of epilepsy
Time of Update: 2023-01-05
, Science2022)Next, the authors asked whether cfos-KCNA1 gene therapy could achieve the purpose of reducing the frequency of epilepsy in a chronic epilepsy model。 The authors tested the combination in a KA (kainic acid)-induced mouse model of chronic epilepsy and used EcoG to record data on brain wave activity.
-
Clearing the fog of encephalitis ---- eosinophilic meningitis
Time of Update: 2023-01-05
After 1 month of follow-up, the patient had no discomfort, no abnormalities in neurological examination, lumbar puncture cerebrospinal fluid pressure was 220mmH2 O, cerebrospinal fluid routine showed the number of white blood cells 16, cytology: lymphocytic inflammation, no eosinophils.
