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New important review: research advances in Alzheimer's disease over the past two decades
Time of Update: 2022-11-25
Birth of Alzheimer-specific markersAt the turn of the 21st century, several cerebrospinal fluid biomarkers were considered specific markers of Alzheimer's disease: amyloid β42 (Aβ42) and phosphorylated tau, and were used in some research institutions and clinics.
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How MRI diagnoses a small amount of arachnoid hemorrhage
Time of Update: 2022-11-25
Let's see how SWI changesFrom the top to the figure below: SWI amplitude map original map, phase map original map, amplitude map Minp diagram, phase map Minp diagram, right temporal area and left frontal region sulcus all the above images show band-like low signal, with the amplitude map and phase map of the Minp map showing the most clearly, indicating a small amount of subarachnoid hemorrhage.
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Case: starch-iodine test: a colored tool used in Horner syndrome to objectively confirm anhidrosis
Time of Update: 2022-11-25
(Figure 1: A: Thinly coated with 1 g starch, the subsequent dried 2% iodine tincture turns a striking blue color in the presence of sweat; B: ptosis and slight miosis)(Figure 2: Left lateral medulla oblongata infarction seen in DWI)： ， 。 ， ， A 46-year-old man presents to the emergency department with nausea, dizziness, dysphagia, and hiccups.
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Neuron: The role of cardiovascular pressure reflex circuits in sleep control
Time of Update: 2022-11-25
The authors found that optogenetic activation of GABAERGIC neurons in the CVLM region of GAD2-cre mice resulted in a significant increase in NREM sleep, in addition to a decrease in blood pressure and heart rate (Figures 5B, 5F).
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CGP Editor's Choice: Selected High-Impact Papers on Depression
Time of Update: 2022-11-25
No. 01Expert advice: Clinical application of trazodone hydrochloride sustained-release agent: backhand_index_pointing_left:No. 02Cohort study reveals relationship between risk of depression and stroke in older adults: backhand_index_pointing_left:No. 03GERD, which is in a high global trend, is not only "heartburn" but also "uncomfortable"?
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Scientists used single-cell omics techniques to reveal key gene regulatory networks that guide the development and maturation of the prefrontal cortex
Time of Update: 2022-11-25
Integrative analyses define the dynamic trajectories of each cell type, revealing major gene expression reconfiguration at the prenatal-to-postnatal transition in all cell types followed by continuous reconfiguration into adulthood and identifying regulatory networks guiding cellular developmental programs, states, and functions.
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JOS: use of mechanical thrombectomy in acute stroke patients with moderate to severe pre-stroke disability
Time of Update: 2022-11-25
00906 Several randomized trials have demonstrated the effectiveness of mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) with large vessel occlusion (LVO) and pre-morbidly modified Rankin Scale (mRS) score <2.
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Xu Guixing's hand-drawn | head CT signs hand-drawn essence
Time of Update: 2022-11-25
Cerebral infarction, cerebral hemorrhage and brain trauma are common diseases in neurology, and the diagnosis and treatment involve neurology and internal and external, emergency, severe disease and o
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Cerebellar dizziness and vertigo: etiology, diagnostic evaluation, and treatment
Time of Update: 2022-11-25
Dizziness and vertigo are common symptoms in the general population. The most common causes are peripheral or central vestibular or ocular dyskinesia, functional impairment, or rare nonvestibular diso
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Neurology cases: continuous unilateral blinking associated with neonatal cerebellar epilepsy
Time of Update: 2022-11-25
The 4-month-old baby girl who has had persistent left eye blinking with ipsilateral head rotation since birth undergoes epilepsy examination (video). MRI showed a mass in the left upper foot of the ce
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Whether the frustration quotient is high or not, dopamine has the final say; The ability to resist pressure is not strong, dopamine has the final say: the VTA-NAc loop is the key!!
Time of Update: 2022-11-25
With a real-time behavioral classification method, the researchers also used optogenetic means to specifically activate DA neurons projected to NAcs using optogenetic means when mice were thwarted (random-open-loop stimulation) or performing specific behaviors.
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With these masters, it is difficult to do spinal MRI well!
Time of Update: 2022-11-25
The FOV of spinal scan is large, and the surrounding anatomical structure is complex, and there are many moving organs, such as unreasonable selection of lipid pressing technology, and it is difficult to obtain ideal image quality.
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Nature: Published acupuncture research in Nature to reveal the existence of acupuncture points, Harvard full professor Ma Qiufu returned to China and joined Westlake University
Time of Update: 2022-11-25
In October 2021, Ma Qiufu's team and others published a paper in Nature to achieve a historic breakthrough in acupuncture research, which showed that a class of PROKR2-Cre-labeled dorsal root ganglion (DRG) sensory neurons is essential for low-intensity acupuncture stimulation to activate the vagus-adrenal anti-inflammatory pathway.
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Stroke: Incidence of cerebral vein thrombosis – a population-based study
Time of Update: 2022-11-25
In summary, the incidence of CVT increased over time, but remained lower than in other population-based studies.
3)/million,In summary, the incidence of CVT increased over time, but remained lower than in other population-based studies.
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Clin Cancer Res: Efficacy of nivolumab in combination with temozolomide in the treatment of neuroendocrine tumors
Time of Update: 2022-11-25
CCR-22-1552 Neuroendocrine tumors (NEN) are a heterogeneous group of tumors that include low-grade gastrointestinal and pancreatic neuroendocrine tumors (GEP-NET), thymic and pulmonary neuroendocrine tumors, and aggressive, rapidly growing neuroendocrine carcinoma.
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Nature Communications: A new breakthrough in brain-computer interfaces: Fulun Zhang's team helps paralyzed aphasia "speak" by decoding brain activity
Time of Update: 2022-11-25
" The study developed a device that could decode brain activity in a participant with aphasia paralysis as he silently tried to spell out words to form complete sentences.
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Microgel and star gum in Alzheimer's disease coordinate the clearance of synapses via the complement C1q-dependent pathway
Time of Update: 2022-11-25
Supplementary Figure 3 Changes in the C1q-dependent synaptic proteome of P301S miceSupplementary Figure 4 P301S and P301S; Genetic enrichment analysis of differentially rich proteins identified by the synaptic fraction of C1qKOC1q-dependent elevation of glial cell protein at P301S synapsesThe authors note that many typical astrocyte-specific proteins such as Aqp4, Mlc1, and Slc1a4 increase in a c1q-dependent manner in the 9-month-old P301S synaptic fragment (Figure 2d).
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Cell: A novel mechanism by which microglia lead to increased Aβ deposition in Alzheimer's disease, neuropathological exacerbation, and cognitive deficits
Time of Update: 2022-11-25
Recent research has revealed the key role of microglia and their receptors in influencing the accumulation of Aβ protein and myelin debris in neurodegenerative diseases. But the key intracellular mole
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Abdominal pain in girls, what is the cause?
Time of Update: 2022-11-25
The upper edge of the mass reaches the right subhepatic space, the lower edge to the pelvic entrance, the enhanced scan is unevenly strengthened (Figures 2, 3), its right lower part is attached to the right external iliac artery, the inferior mesenteric artery is compressed and displaced posteriorly, and the umbilical artery, the first branch of the right internal iliac artery, is thickened and twisted, and is the main blood supply artery for the mass (Fig. 4).
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Neurology: the relationship between carotid plaque and blood flow velocity and white matter integrity in middle-aged and elderly people
Time of Update: 2022-11-25
Outcome:Low peak systolic velocity and carotid plaque were associated with high white matter intensity and mean diffusion coefficient of peak width, but were not associated with cardiovascular risk factors and biomarkers of inflammation and cardiac insufficiency.
