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NEJM: Acute basilar artery occlusion thrombectomy test - BAOCHE
Time of Update: 2022-11-25
The authors concluded that for stroke patients with basilar artery occlusion between 6 and 24 hours of onset, the proportion of patients with good functional status at 90 days of thrombectomy was higher than with medical therapy, but was associated with surgical complications and more intracerebral haemorrhage.
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"Alzheimer's disease" marker – a hot project on the rise
Time of Update: 2022-11-25
Research backgroundAlzheimer's disease (AD) is an insidious and slow-degenerative disease that is the most common form of senile dementia, accounting for an estimated 60 to 80 percent of total dementi
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The "Pan" Forum and the Online Exchange Meeting on Research Progress and Scientific Research and Academic Discussion on Depressive Disorders ended successfully
Time of Update: 2022-11-25
Moderator: Professor Yang Fude Professor Wang Yongjun of Shenzhen Kangning Hospital first shared a meta-analysis published by Stanford University - functional neuroimaging student biomarkers for resilience in major depressive disorder (MDD).
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Editor's Choice of Chinese General Practice: Selected Selected Stroke-High Impact Papers in 2022
Time of Update: 2022-11-25
Recognize stroke one second earlierSave the brain to recover well10-29The World Stroke Japan issue editor recommended you to select five excellent high-citation articles published in 2022 by Chinese G
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Nature sub-journal: Activation of a group of neurons in the amygdala leads to overeating
Time of Update: 2022-11-25
In a new study published in Nature Neuroscience, a team led by Cold Spring Harbor Laboratory (CSHL) identified a previously uncharacterized group of single neurons in the amygdala that plays a key role in promoting metabolic responses through behavioral changes: this group of neurons drives mice to choose high-sugar or high-fat foods after a full meal, triggering "hedonistic" overeating and eventually obesity.
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Detailing the anatomy of the vertebrobasilar artery system
Time of Update: 2022-11-25
Branches of the basilar artery9 posterior cerebral artery segmentation10 posterior cerebral artery branches:Central branch, ventricle and choroid plexus, cortical branch11 Posterior fossa arteries and vertebral arteries 1 Composition of the vertebro-basilar artery systemFeatures of the 2 vertebral arteries:There are three strictures in the blood supply area, segments, and intracranial areas3.
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New research may help develop drugs that target γ-secretase
Time of Update: 2022-11-25
By revealing the selective inhibition mechanism of subtypes of progerin, this research work may contribute to the discovery of future drugs targeting γ-secretase.
By revealing the selective inhibition mechanism of subtypes of progerin, this research work may contribute to the discovery of future drugs targeting γ-secretase.
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New important review: research advances in Alzheimer's disease over the past two decades
Time of Update: 2022-11-25
Birth of Alzheimer-specific markersAt the turn of the 21st century, several cerebrospinal fluid biomarkers were considered specific markers of Alzheimer's disease: amyloid β42 (Aβ42) and phosphorylated tau, and were used in some research institutions and clinics.
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Stroke: significance of baseline ischemic core volume for endovascular treatment outcomes in older stroke patients
Time of Update: 2022-11-25
References:Significance of Baseline Ischemic Core Volume on Stroke Outcome After Endovascular Therapy in Patients Age ≥75 Years: A Pooled Analysis of Individual Patient Data From 7 Trials
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Genes involved in neuronal structure and function may prevent Alzheimer's disease
Time of Update: 2022-11-25
” Overexpression of a gene related to cell division, neuronal structure and function may prevent and protect against cognitive decline in mice and humans with Alzheimer's disease (AD), according to a new study by scientists.
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A major breakthrough in stroke genetics research: laying the foundation for the drug development of future stroke
Time of Update: 2022-11-25
The main significance of the studyThe genomic findings obtained from more than 200,000 stroke patients worldwide have laid an important genetic foundation for future biological studies of stroke pathogenesis, which not only identified potential intervention drug targets, but also provided a powerful tool for cross-family genetic risk prediction.
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Case: starch-iodine test: a colored tool used in Horner syndrome to objectively confirm anhidrosis
Time of Update: 2022-11-25
(Figure 1: A: Thinly coated with 1 g starch, the subsequent dried 2% iodine tincture turns a striking blue color in the presence of sweat; B: ptosis and slight miosis)(Figure 2: Left lateral medulla oblongata infarction seen in DWI)： ， 。 ， ， A 46-year-old man presents to the emergency department with nausea, dizziness, dysphagia, and hiccups.
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Ther Drug Monit: ABCC2 gene polymorphisms affect the efficacy and plasma concentration of lacosamide in children with epilepsy
Time of Update: 2022-11-25
The journal Therapeutic Drug Monitoring published a study evaluating the correlation between the ABCC2 1249G>A (rs2273697) and -24C>T (rs717620) genotypes and their haplotype and diploid combinations with the blood concentration and efficacy of lacosamide (LCM) in Uyghur children with epilepsy.
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JAMA Netw Open: An unfortunate childhood may not be cured in a lifetime! Adverse childhood experiences are associated with a faster rate of cognitive decline in later life...
Time of Update: 2022-11-25
Changes in overall cognition, episodic memory, and executive function over 4 years were also comparable across the 3 threat-related ACE categories (Figure A).
Changes in overall cognition, episodic memory, and executive function over 4 years were also comparable across the 3 threat-related ACE categories (Figure A).
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E&B: Efficacy of perampanel adjuvant therapy in children with uncontrolled epilepsy
Time of Update: 2022-11-25
Original source:Li Gao, Lina Shi, et al, Effectiveness and tolerability of adjunctive perampanel in the treatment of pediatric patients with uncontrolled epilepsy: A retrospective, single-center, real-world study, Epilepsy & Behavior, 2022, https://doi.
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Neuron: How do you perceive cold environments? Scientists reveal spinal nerve circuits for cold sensitivity
Time of Update: 2022-11-25
summaryIn this paper, it was found that there is a class of inhibitory neurons in the spinal cord, Kcnip2-positive neurons, which regulate the body's sensitivity to the external cold environment, and this type of neuron participates in cold analgesia when the function is normal, and causes cold abnormal pain when it is abnormal.
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Neuron: The role of cardiovascular pressure reflex circuits in sleep control
Time of Update: 2022-11-25
The authors found that optogenetic activation of GABAERGIC neurons in the CVLM region of GAD2-cre mice resulted in a significant increase in NREM sleep, in addition to a decrease in blood pressure and heart rate (Figures 5B, 5F).
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How MRI diagnoses a small amount of arachnoid hemorrhage
Time of Update: 2022-11-25
Let's see how SWI changesFrom the top to the figure below: SWI amplitude map original map, phase map original map, amplitude map Minp diagram, phase map Minp diagram, right temporal area and left frontal region sulcus all the above images show band-like low signal, with the amplitude map and phase map of the Minp map showing the most clearly, indicating a small amount of subarachnoid hemorrhage.
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Ulnar impingement syndrome, subacromial impingement syndrome, a clear text!
Time of Update: 2022-11-25
Imaging findings: typical findings on standard posteroanterior (shoulder abduction 90°, elbow flexion 90°, wrist neutrality) include positive ulnar variation, occasionally neutral ulnar variation or negative ulnar variation, and other factors contributing to relatively long ulnar or increased dorsicity tilt at the distal radius, such as deformity healing of distal radius fractures (figure 1); Sclerosis and subchondral capsular changes on the ulnar surface of the proximal lunar bone, radial side of the proximal triangular bone, and ulnar head (Fig. 1, 2).
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Front.mol neurosci-WNT signaling for neurogenesis and brain tumorigenesis
Time of Update: 2022-11-25
However, the WNT pathway has multiple key roles in neurogenesis (Figure 2), and some conclusions related to the decision of neural stem cells to proliferate or differentiate during neuronal development are contradictory.
