Stroke: Incidence of cerebral vein thrombosis – a population-based study

Studying the baseline incidence of cerebral venous thrombosis (CVT) prior to COVID-19 and limitations reported in previous literature will help improve understanding of the disease and how risk may change
in the post-COVID era.

Scholars from Canada studied the incidence of CVT using linked administrative data from British Columbia, Canada (population 5.
2 million), through the incidence of CVT in published literature, and searched MEDLINE and EMBASE for articles
on the incidence of CVT in adults as of November 2, 2021.
A random-effects limiting maximum likelihood model
was used.
Publication bias
was assessed using the Egger test and visual inspection of the symmetry of the funnel plot.

Results showed that between 2000 and 2017, there were 554 unique CVT cases in British Columbia (mean age 50.
9 years, 55.
4% female); The overall annual incidence was 8.
7 (95% CI 8.
0 to 9.
4) per million
.
Throughout the study period, the incidence increased over time in men and gradually increased in women from 2011 to 2017
.
At the same time, 22 other studies
on the incidence of CVT up to 2020 were identified.
Overall, the annual incidence was 12.
1 (95% CI '9.
9 to 14.
3)/million, with significant heterogeneity between studies (I2 98.
8%, Qp <0.
001).

There was no significant association
between incidence and metaregression between study years, study quality scores, or GNI per capita in study countries.

In summary, the incidence of CVT increased over time, but remained lower than in other population-based studies
.
There was significant heterogeneity in the literature, which may be affected
by publication bias.

References:

Incidence of Cerebral Venous Thrombosis: A Population-Based Study, Systematic Review, and Meta-Analysis.
https://doi.
org/10.
1161/STROKEAHA.
122.
039390Stroke.
2022;0