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To diagnose delayed cognitive impairment after stroke, these 3 conditions need to be met
Time of Update: 2022-10-14
Then, Professor Qu Qiumin concluded that the mechanism of late-onset PSCI may be based on cerebral small vascular disease, stroke events induce disorders of cerebral blood flow regulation function, induce inflammatory response, chronic ischemia of brain tissue, damage of the brain barrier, and then lead to degeneration of cerebral white matter, secondary cerebral atrophy, these mechanisms together lead to patients with delayed PSCI, manifested as no cognitive impairment in the early stage of stroke.
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Science is another masterpiece! The latest Nobel laureate Pääbo has collaborated to uncover the differences between modern humans and Neanderthals' neocortex of the brain
Time of Update: 2022-10-13
By overexpressing in the neocortex of developing mice and ferrets, knocking out in fetal human neocortex tissue, and genome-edited brain organoids, the study found that the modern human variant, hTKTL1, rather than the Neanderthal variant, increased the richness of basal radial radial glial cells (bRG) but not the richness of intermediate progenitor cells (bIPs).
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J Neuroinflammation—Chen Gang's research group revealed that Schwann cell Pannexin 1 regulates neuropathic pain by mediating inflammatory responses
Time of Update: 2022-10-13
Written by - Wei Zhongya Responsible Editor - Wang Sizhen Editor - Xia Ye Neuropathological pain is pathological pain caused by nerve damage or related diseases. Because of its relatively complex path
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【Nature】Heavy! Scientists have mapped multiple omics genes for human brain development
Time of Update: 2022-10-13
a molecular fingerprint 01 The researchers took a new approach to studying the development of the human brain: the organoids that are being grown and used — millimeter-sized three-dimensional tissues that can grow from so-called pluripotent stem cells.
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J Neurosci-Hu Bo group revealed the role of dorsal hippocampus-positive interneurons in joint motor learning and their network activity mechanisms
Time of Update: 2022-10-13
Written by Hu Bo, edited by Li Rongyao—edited by Wang Sizhen—Xia Ye links two events that occur at different times to make appropriate motor behaviors, and Associative motor learning is one of the imp
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Neuron Jiayi Zhang/Liang Chen/Ying Mao of Fudan University reveals a new neural mechanism encoding time prediction information
Time of Update: 2022-10-13
To address the question of which brain regions play a key role in human time perception in the order of seconds to ten seconds, the authors used stereoplephalogram (SEEG) recordings of 11 epilepsy patients to localize seizures.
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JAMA Sub-Journal: The Fudan team found that healthy eating and exercise or reducing the risk of death in Parkinson's disease patients are two magic weapons!
Time of Update: 2022-10-13
The study assessed the value of healthy eating patterns and active lifestyles before and after Parkinson's disease onset using a well-researched large prospective follow-up cohort of well-gathered information, and the association between the two and the reduced risk of death is expected to provide clinicians with new ideas for improving outcomes and allowing more patients to benefit from relatively simple interventions.
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【Neuron】Fudan Department of Brain and Huashan Hospital Team: The important role of the optic cortex in temporal information prediction
Time of Update: 2022-10-13
This article is the original of the translational medicine network, please indicate the source when reprinting Author: LilyAlthough time is important in our daily lives, our understanding of how the h
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PNAS Jianwen Deng/Wang Chaoxia/Yun Yuan team revealed the mechanism of mitochondrial injury in inclusion somatic disease in the neuronal nucleus and potential therapeutic targets
Time of Update: 2022-10-13
On October 3, 2022, the team of Deng Jianwen/Wang Chaoxia/Yuan Yun, Department of Neurology, Peking University First Hospital, published a model entitled CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila at PNAS The research paper, the first to construct a NIID transgenic Drosophila model, elucidated the molecular mechanisms by which uN2CpolyG toxic proteins mediate mitochondrial dysfunction and neurodegeneration, and provides a potential therapeutic target for the disease.
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【Review】Depression treatment moves towards precision medicine, and immune targeted therapy "comorbid depression"
Time of Update: 2022-10-13
1 The causal relationship between immune disorders and depressionA large number of studies have shown that immune disorders and depression are correlated: elevated levels of pro-inflammatory cytokines and proteins in the blood and cerebrospinal fluid (CSF) in patients with MDD, weakened adaptive immune responses, changes in relative abundance of specific immune cell types, bias towards autoimmunity, increased microglia activation, and other immune changes.
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Nature Brainstem ADCYAP1+ neurons mediate pathological behavior
Time of Update: 2022-10-13
Written by | Jun infection is one of the serious threats that organisms need to face in survival [1], while inducing immune cell responses, infection will also trigger a series of changes in the body,
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Frequent nightmares, or omen of dementia! The Lancet: Nightmares ≥ once a week increase the risk of dementia by 120%!
Time of Update: 2022-10-13
An association between nightmares and cognitive decline was found: higher frequency nightmares (1 or more times a week) were nearly 3-fold higher than the risk of cognitive decline in middle age, and the likelihood of developing dementia in older age was increased by 120%!
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"Immunity": The team of the Second Hospital of Zhejiang University found for the first time that resting microglia can directly affect the electrical excitability of neurons!
Time of Update: 2022-10-13
The removal of microglia-derived PDGFB leads to a weakening of the K+ current in PVN presympathetic neurons and sympathetic excitation+Studies have shown that PDGFB binds to two receptors, PDGFRα and PDGFRβ.
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Science: Obesity is a neurodevelopmental disorder, early brain development or the main determinant of obesity
Time of Update: 2022-10-13
Notably, classical studies in mice and humans have shown that during critical periods of early development, nutritional status can permanently alter the body's energy balance regulation and lead to obesity, a phenomenon known as "developmental programming.
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Problems with the mouth may plant the seeds of Alzheimer's disease
Time of Update: 2022-10-13
Meanwhile, another study in the Journal of Alzheimer's Disease Reports found that porphyrin monas gums also cause elevated levels of many pro-inflammatory factors in the brain, including interleukin-1 and interleukin-6.
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What are the advantages of universal "chimeric cells" for DMD over gene therapy that prove long-term effectiveness?
Time of Update: 2022-10-13
The official website of each company——List of recent hot events——▼October 18, the application and development trend of biopharmaceutical safety detection technologyOctober 8, 2022 eMedClub News/-September 26, 2022, Dystrogen Therapeutics announced that a clinical study of DT-DEC01, a research-based engineered cell therapy for Duchenne muscular dystrophy (DMD), was achieved six months later in a clinical study under a hospital exemption agreement.
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Nat Aging—Alzheimer's mouse glial cells participate in synaptic clearance through the complement pathway
Time of Update: 2022-10-13
Written by Jane Cheng, Editor-in-Chief—Sizhen Wang—Chronic neuroinflammation in Xia Ye is a hallmark of Alzheimer's Disease (AD), manifested by glial hyperplasia, elevated levels of pro-inflammatory f
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Poor teeth are susceptible to dementia? New Study: The culprit turned out to be it
Time of Update: 2022-10-13
Meanwhile, another study in the Journal of Alzheimer's Disease Reports found that porphyrin monas gums also cause elevated levels of many pro-inflammatory factors in the brain, including interleukin-1 and interleukin-6.
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"Brain Behavior and Immunization" is heavy! Scientists have found that taking specific probiotics during adolescence can regulate endotoxin-induced immune responses and bowel disorders, and improve depressive-like behavior
Time of Update: 2022-10-13
235 issues | Gut Junjun WeeklyDepression, probiotics; Bariatric surgery, intestinal morphology, glucose absorption; Sugar, bacterial imbalance, metabolic syndromeHappy National Day to the people of the whole country!
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Typical radiographic findings of intracranial hemorrhage, summarized in one article
Time of Update: 2022-10-13
Hemorrhagic contusion of the right anterior temporal lobe and subarachnoid hemorrhage covering the brain sulcus (triangular arrow) are shown in the figure, and arc-shaped subdural hematoma foci (long tail arrow) are visible under the bone plate.
