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Cell: First discovery! Social fear or social cattle, the key to see this neural pathway!
Time of Update: 2022-10-13
In addition, the researchers also found that the anatomy of PIL in rats and human brains and the distribution of PTH2 receptors in MPOA are very similar, indicating that PIL → MPOA pathways in humans are likely to play a similar role in regulating social behavior.
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Express promotes the main DMD gene therapy into the clinic, and the new sharp joint efforts to create a gene therapy pipeline
Time of Update: 2022-10-13
▲If you have any business needs, please long press to scan the QR code above, or▎Editor of WuXi AppTec content teamSolid Biosciences today announced a merger agreement with AavantiBio to acquire AavantiBio's gene therapy pipeline.
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This kind of blood pressure reduction is easy to cause cerebral infarction, and the correct method is ...
Time of Update: 2022-10-13
The relationship between watershed cerebral infarction and blood pressure The pathophysiology of subcortical CWSI has traditionally been thought to be associated with carotid artery stenosis and hemodynamic changes (hypotension) leading to hypoperfusion in the brain, and has also been thought to be caused by microembolism.
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"Brain Behavior and Immunization" is heavy! Scientists have found that taking specific probiotics during adolescence can regulate endotoxin-induced immune responses and bowel disorders, and improve depressive-like behavior
Time of Update: 2022-10-13
235 issues | Gut Junjun WeeklyDepression, probiotics; Bariatric surgery, intestinal morphology, glucose absorption; Sugar, bacterial imbalance, metabolic syndromeHappy National Day to the people of the whole country!
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PNAS Jianwen Deng/Wang Chaoxia/Yun Yuan team revealed the mechanism of mitochondrial injury in inclusion somatic disease in the neuronal nucleus and potential therapeutic targets
Time of Update: 2022-10-13
On October 3, 2022, the team of Deng Jianwen/Wang Chaoxia/Yuan Yun, Department of Neurology, Peking University First Hospital, published a model entitled CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila at PNAS The research paper, the first to construct a NIID transgenic Drosophila model, elucidated the molecular mechanisms by which uN2CpolyG toxic proteins mediate mitochondrial dysfunction and neurodegeneration, and provides a potential therapeutic target for the disease.
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Typical radiographic findings of intracranial hemorrhage, summarized in one article
Time of Update: 2022-10-13
Hemorrhagic contusion of the right anterior temporal lobe and subarachnoid hemorrhage covering the brain sulcus (triangular arrow) are shown in the figure, and arc-shaped subdural hematoma foci (long tail arrow) are visible under the bone plate.
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Science: Obesity is a neurodevelopmental disorder, early brain development or the main determinant of obesity
Time of Update: 2022-10-13
Notably, classical studies in mice and humans have shown that during critical periods of early development, nutritional status can permanently alter the body's energy balance regulation and lead to obesity, a phenomenon known as "developmental programming.
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Neuron Jiayi Zhang/Liang Chen/Ying Mao of Fudan University reveals a new neural mechanism encoding time prediction information
Time of Update: 2022-10-13
To address the question of which brain regions play a key role in human time perception in the order of seconds to ten seconds, the authors used stereoplephalogram (SEEG) recordings of 11 epilepsy patients to localize seizures.
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【Neuron】Fudan Department of Brain and Huashan Hospital Team: The important role of the optic cortex in temporal information prediction
Time of Update: 2022-10-13
This article is the original of the translational medicine network, please indicate the source when reprinting Author: LilyAlthough time is important in our daily lives, our understanding of how the h
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The team of Neuron Jiayi Zhang/Ying Mao/Liang Chen reveals the important role of the optic cortex in temporal information prediction
Time of Update: 2022-10-13
On October 3, 2022, Zhang Jiayi's team from the Institute of Brain Sciences/State Key Laboratory of Medical Neurobiology of Fudan University, in collaboration with Mao Ying and Chen Liang of Huashan Hospital affiliated to Fudan University, published an article on Neuron in Neuron, revealing the important mechanism of temporal prediction information of optic cortex encoding.
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Fever died after 1 day, the sharp progression of the disease is behind this disease ...
Time of Update: 2022-10-13
, and repeated metabolic crisis, metabolic acidosis, and hyperlactemia during hospitalization, combined with cranial CT and hematuria tandem mass spectrometry, clinically considered Leigh syndrome 。 Vitamin B2, three-dimensional B tablets, folic acid tablets, coenzyme Q10 and levocaniptine were given to improve abnormal energy metabolism, blood purification and removal of metabolites, but due to internal environmental disorders that are difficult to correct, multiple organ failure, family members give up treatment and die.
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Heavy! Chinese scientists have uncovered the mechanism by which lectins cause Alzheimer's disease
Time of Update: 2022-10-13
Alzheimer's disease, also known as senile dementia, is a progressive neurodegenerative disease that is the cause of nearly two-thirds of people with dementia. The deposition of amyloid β (Aβ) to form
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Molecular Psychiatry: Alcohol-dependent enzymes promote excessive storage of fearful memories
Time of Update: 2022-10-13
Figure 3: Downregulation of Prdm2 increases amygdala neuronal activitysummaryIn this paper, the epigenetic modification enzyme PRDM2 is found to be used in regulating fear memory consolidation through the dmPFC-BLA neural circuit: Enhancing neuronal activity in the BLA region after reduced PRDM2 expression promotes fear memory.
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JCI Guo Hui/Xia Kun/Tan Jieqiong collaborated to reveal the genetic and molecular mechanisms by which GIGYF1 is involved in autism risk
Time of Update: 2022-10-13
Autism Spectrum Disorder (ASD) is a class of neurodevelopmental disorders that occur early in childhood development with core symptoms of deficits in social interaction and communication and repetitiv
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Science I Early treatment of newborns may delay the onset of Huntington's disease
Time of Update: 2022-10-13
Recently, the research team of Sandrine Humbert from the Grenoble Institute of Neuroscience in France published an article in Science titled Treating early postnatal circuit defect delays Huntington' disease onset and pathology in mice, found that in the first week after birth, HD-mode mice have lower excitatory synaptic activity in layers 2/3 of the cortex, low glutamate receptor expression, and exhibit sensorimotor deficits, but at the second week, these defects can be self-repaired and returned to normal levels.
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Myasthenia gravis medication strategy is here - be wary of medication crisis!
Time of Update: 2022-10-13
*For medical professionals onlyThe use of drugs has certain application contraindications and their respective characteristics, which should be selected according to the individual situation of the pa
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So surprised! Scientists found that glial progenitor cells actually directly engulfed synapses and reshaped neural circuits
Time of Update: 2022-10-13
1038/s41593-022-01170-xThe images in the article are from referencesClick on the blue letter to follow usMicroglia and astrocytes encroach on excess synapses during the first week after birth, promoting synaptic fineness in the mammalian visual system.
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【Nature sub-journal】Targeting senescent cells is expected to fight inflammation and cognitive decline!
Time of Update: 2022-10-13
Recommended Live/Events09/27 14:00-17:30 ShanghaiInnovative technology to facilitate the summit forum on accurate diagnosis and treatment of tumorsScan the code to participate for freeNovember 01-02 09:00-17:30 ChongqingThe 1st Southwest Single Cell Omics Technology Application ForumScan the code to participate for freeNovember 25-27 09:00-17:30 ShanghaiThe 4th Shanghai International Cancer CongressScan the code to participateThis article is the original of the translational medicine network, please indicate the source when reprinting Author: MiaCell senescence may be a mediating factor in inflammation-related tissue dysfunction.
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The Sci Adv Shengneng Yin/Mao Bingyu/Ding Yuqiang team collaborated to discover a new mechanism of AMPA receptor ubiquitination in the regulation of excitatory synaptic function
Time of Update: 2022-10-13
In addition, RNF220 is also involved in the transport expression of AMPA receptors in neuronal cell membranes for protein stability regulation mechanisms.
In addition, RNF220 is also involved in the transport expression of AMPA receptors in neuronal cell membranes for protein stability regulation mechanisms.
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PNAS: The gut microbiota determines what you want to eat by influencing the brain.
Time of Update: 2022-10-13
Paper link: open reprint welcome to the circle of friends and WeChat group Written by | Wang CongEdit | Wang DuoyuTypography | Water into the textHumans, like other mammals, are occupied by trillions of microbes, including bacteria, viruses and fungi, collectively known as the commensal flora.
