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Cell Prolif︱Lai Liangxue/Zhang Kun/Zou Qingjian team successfully constructed a technical system for safe and efficient directional induction of motor neurons in vivo
Time of Update: 2022-09-09
In addition, the authors identified the subcutaneous cell clumps by immunofluorescence, and found that the transplanted NILB-hiPSCs were mainly in the direction of neural differentiation subcutaneously, and abundantly expressed motor neuron-related markers TUJ1, MAP2, HB9 and ChAT (Fig. 3B) .
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eClinicalMedicine︱Wang Qing's team reports Parkinson's disease dementia-related index quantification: quantitative EEG, serum metabolism and inflammation
Time of Update: 2022-09-09
(For details, see the "Logical Neuroscience" report (click to read): eClinicalMedicine︱ Meta-analysis: Efficacy of repetitive transcranial magnetic stimulation on Parkinson's disease), Wang Qing's team once again published online the title "QEEG indices are associated with inflammatory and metabolic Factors risk in Parkinson's disease dementia: An observational study" Original article .
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Express disease recurrence rate reduced by more than 50%!
Time of Update: 2022-09-09
▎Edited by WuXi AppTec Content TeamTG Therapeutics recently announced that its investigational antibody ublituximab targeting the CD20 protein has achieved the primary endpoint in the ULTIMATE I & II Phase 3 clinical trial in the treatment of relapsing multiple sclerosis (RMS) patients.
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The new anticoagulant Asundexian has a better outlook in patients after myocardial infarction or stroke, and the RESULTS of the PACIFIC study were published esc 2022
Time of Update: 2022-09-09
Research resultsAt 6 months, asundexian did not reduce the combined event endpoint of occult cerebral infarction or recurrent symptomatic ischemic stroke compared with placebo, and there was no dose-dependent primary efficacy outcome.
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To save his brother's life, Harvard graduates tailored gene therapy for him
Time of Update: 2022-09-09
▎ WuXi AppTec content team editorOn August 9, 2022, Cure Rare Disease (CRD), a Boston-based nonprofit organization, announced that the FDA had approved its IND application for a CRISPR gene-edited therapy called CRD-TMH-001 for the treatment of Duchenne muscular dystrophy (DMD).
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Detect Parkinson's disease by breathing during sleep!
Time of Update: 2022-09-09
Artificial intelligence-enabled detection and assessment of Parkinson's disease using nocturnal breathing signals.
Artificial intelligence-enabled detection and assessment of Parkinson's disease using nocturnal breathing signals.
Artificial intelligence-enabled detection and assessment of Parkinson's disease using nocturnal breathing signals.
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A text identification: the unexpected diseases behind "bad memory"
Time of Update: 2022-09-09
[4] China Dementia and Cognitive Impairment Diagnosis and Treatment Guidelines Writing Group, Chinese Medical Doctor Association Neurology Branch Cognitive Impairment Disease Professional Committee.
[4] China Dementia and Cognitive Impairment Diagnosis and Treatment Guidelines Writing Group, Chinese Medical Doctor Association Neurology Branch Cognitive Impairment Disease Professional Committee.
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Central vertigo, peripheral vertigo... 5 kinds of vertigo in one article
Time of Update: 2022-09-08
(2) Drug-induced vertigo: classified as follows according to the correlation between symptom onset and duration of medication .
(2) Drug-induced vertigo: classified as follows according to the correlation between symptom onset and duration of medication .
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Interview with Professor Chen Qin: Single-molecule immunoassay technology helps AD early diagnosis and early screening
Time of Update: 2022-09-08
At the same time, with the release of relevant guidelines for institutions including NIA-AA and IWG, as well as the release of domestic AD diagnostic guidelines and AD-derived MCI expert consensus, AD blood biomarker detection based on single-molecule immunoassay technology has begun to emerge in clinical applications, and the ultra-high detection sensitivity performance of single-molecule immunoassay technology provides real possibilities for clinical AD diagnosis and screening.
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New target to prevent Alzheimer's disease!
Time of Update: 2022-09-08
▎Edited by WuXi AppTec Content TeamBeta-amyloid builds up in the brains of Alzheimer's patients many years before symptoms appear . Scientists have invested a lot of time and energy in clearing beta a
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Interview with Professor Fan Yuhua: TK Supplemental Treatment of AIS – From Research Progress to Clinical Practice
Time of Update: 2022-09-08
A Phase II clinical study (ReMEDy) on recombinant tissue kallikrein in the treatment of AIS was released at ISC 2021 last year, showing that TK supplemental therapy can increase the proportion of patients with NIHSS score ≤1 by 22%, and the cumulative recurrence rate in 90 days is only 2.
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After getting drunk once, your brain is forever changed...
Time of Update: 2022-09-08
Now, a new study published in the "Proceedings of the National Academy of Sciences" has given the answer in the affirmative: The first time you get drunk, not only does it change the shape of neurons in your brain, but it can even last a lifetime .
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Front Aging Neurosci︱ Zeng Yanbing's team builds a predictive model and reveals the impact of behavioral changes on cognitive impairment in the elderly
Time of Update: 2022-09-08
In August 2022, the team of Associate Professor Zeng Yanbing of Capital Medical University and the team of Tencent Tianyan Laboratory published an article entitled "Using machine learning algorithms for predicting cognitive impairment and identifying modifiable factors among Chinese elderly people" on Frontiers in Aging Neuroscience, proposing developed a predictive model of cognitive impairment risk and explored the impact of behavioral changes on cognitive impairment .
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J Neuroinflammation︱Chang Chunqi/Zhang Jian's team found that targeting proteoglycan receptors protects white matter integrity and promotes neurological recovery after hemorrhagic stroke
Time of Update: 2022-09-08
In August 2022, Chang Chunqi and Zhang Jian's team from the Medical Department of Shenzhen University published a research paper entitled "Modulation of the proteoglycan receptor PTPσ promotes white matter integrity and functional recovery after intracerebral hemorrhage stroke in mice" in the Journal of Neuroinflammation, proposing ISP It can improve the inflammatory response around hematoma, increase white matter integrity and remyelination, and promote the recovery of nerve function after ICH .
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Onset with "bitemporal pain", don't just think of Guillain-Barre syndrome
Time of Update: 2022-09-08
Clinical manifestations of idiopathic intracranial hypertensionHeadache, total cranial headache, worse upon awakening and may be aggravated by movements that raise intracranial pressure;Papilloedema and vision loss: It usually occurs symmetrically, but can be unilateral .
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Drooling at the BBQ!
Time of Update: 2022-09-08
▲ Some responses of specific brain regions when volunteers saw different pictures (Image source: Reference [2])They called this group of neurons the ventral food component (VFC).
▲ Some responses of specific brain regions when volunteers saw different pictures (Image source: Reference [2])They called this group of neurons the ventral food component (VFC).
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Academic Express is heavy!
Time of Update: 2022-09-08
Author: Professor Huo Xiaochuan of Beijing Tiantan Hospital Wen Yuan: "Neural Intervention Online"The international multi-center randomized controlled study DIRECT-SAFE, which was carried out in cooperation with China, Australia and other countries, was published online in The Lancet (Impact Factor IF=202.
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Science: Down syndrome cognitive dysfunction, can be treated!
Time of Update: 2022-09-07
The Inserm team at the Lille Neuroscience and Cognition Laboratory (Inserm/Université de Lille, Lille University Hospital) and their counterparts at the University Hospital of Lausanne (CHUV) have teamed up to test the efficacy of GnRH injection therapy to improve cognitive function in a small group of Down syndrome patients.
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Express the first approved therapy!
Time of Update: 2022-09-07
▎Edited by WuXi AppTec Content TeamLearn more about FDA-approved new drugsPlease click the image below to visit our appletReferences:[1] FDA Approves First Treatment for Acid Sphingomyelinase Deficiency, a Rare Genetic Disease.
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Healthy eating and regular exercise may reduce the risk of death from Parkinson's disease Frontiers
Time of Update: 2022-09-07
The study shows that healthy eating and exercise habits can significantly reduce mortality before or after a diagnosis of Parkinson's disease (PD).
The study shows that healthy eating and exercise habits can significantly reduce mortality before or after a diagnosis of Parkinson's disease (PD).
