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Academic Express is heavy!

 Last Update: 2022-09-08
 Source: Internet
 Author: User

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The international multi-center randomized controlled study DIRECT-SAFE, which was carried out in cooperation with China, Australia and other countries, was published online in The Lancet (Impact Factor IF=202.

Research Introduction

DIRECT-SAFE is an international, multicenter, prospective, randomized, open-label, endpoint-blinded trial (NCT03494920)

The purpose of this study was to verify whether the clinical outcome of direct thrombectomy within 4.

RESULTS: 295 patients were randomly assigned to either direct thrombectomy (n=148) or bridging therapy (n=147)

Based on the results of the DIRECT-SAFE study, no noninferiority of direct thrombectomy was found compared with bridging therapy

The DIRECT-SAFE study provides evidence to support bridging therapy
.

Although bridging therapy is recommended by default in the guidelines, based on all available clinical research evidence, specific patients with potential increased risk of intravenous thrombolysis, including late time windows or large infarct volumes, and direct travel can quickly provide For patients in hospitals where emergency endovascular thrombectomy is performed, direct mechanical thrombectomy can be considered
.

So far, six RCT studies of bridging therapy (DIRECT-MT, DEVT, SKIP, MR CLEAN-NO IV, DIRECT-SAFE, SWIFT DIRECT) have published results, and further meta-analysis (Improving Reperfusion strategies in Ischemic Stroke, IRIS) will Provides subgroups more likely to benefit
.
Author: Professor Huo Xiaochuan of Beijing Tiantan Hospital Wen Yuan: "Neural Intervention Online"

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