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【Nature sub-journal】Targeting senescent cells is expected to fight inflammation and cognitive decline!
Time of Update: 2022-10-13
Recommended Live/Events09/27 14:00-17:30 ShanghaiInnovative technology to facilitate the summit forum on accurate diagnosis and treatment of tumorsScan the code to participate for freeNovember 01-02 09:00-17:30 ChongqingThe 1st Southwest Single Cell Omics Technology Application ForumScan the code to participate for freeNovember 25-27 09:00-17:30 ShanghaiThe 4th Shanghai International Cancer CongressScan the code to participateThis article is the original of the translational medicine network, please indicate the source when reprinting Author: MiaCell senescence may be a mediating factor in inflammation-related tissue dysfunction.
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Heavy! Chinese scientists have uncovered the mechanism by which lectins cause Alzheimer's disease
Time of Update: 2022-10-13
Alzheimer's disease, also known as senile dementia, is a progressive neurodegenerative disease that is the cause of nearly two-thirds of people with dementia. The deposition of amyloid β (Aβ) to form
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The predictive power of Alzheimer's disease biomarkers in the preclinical phase
Time of Update: 2022-10-13
1093/brain/awac250)Related ReadingNEJM Journal CollectionNEJM Journal Watch, published by NEJM Group, invites internationally renowned physicians to review important papers in the field of medicine and help physicians understand and apply the latest advances.
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【Science sub-journal】Shocked! Studies have found that obesity is a neurodevelopmental disorder
Time of Update: 2022-10-13
This article is the original of the translational medicine network, please indicate the source when reprinting Author: JevinRecent genome-wide association studies have shown that obesity is primarily
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Why do you always feel that you have more moments of social death? Nature: The brain is more inclined to characterize memories as negative
Time of Update: 2022-10-13
Heng Yu from the Concave Non-Temple Qubit | Official number QbitAII don't know if you have such an experience:When you tell someone about a social death with great pain, people say, "Are you okay?" ”M
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Nature Neuroscience: How does the brain make decisions? Scientists reveal corticosteral-thalamic neural circuits for decision-making behavior
Time of Update: 2022-10-13
1038/s41593-022-01171-wThe images in the article are from referencesClick on the blue letter to follow usOn September 28, 2022, the Nuo Li research team in the Department of Neuroscience of Baylor College of Medicine revealed the functional neuronal activity of the frontal cortex in the decision-making behavior of the thalamus.
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CNSNT-Gu Xiaoping's team revealed that enhancing astrocyte networks can improve brain network abnormalities and cognitive dysfunction caused by long-term isoflurane anesthesia
Time of Update: 2022-10-13
The above results suggest that long-term isoflurane anesthesia can lead to abnormal functional connections between the hippocampus region and other brain regions, and these abnormal changes can be reversed by reconstructing the GJs-Cx43-mediated network of astrocytes.
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The NPP-Luo Xiongjian research group used Mendelian randomization to screen potential drug targets for the treatment of mental illness
Time of Update: 2022-10-13
Written by Liu JieweiResponsible editor - Wang SizhenEditor-in-Charge - Xia YeMental illness poses a huge economic burden to society and a global public health threat [1, 2]. Drug treatment of mental
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Science & Progress: Why does Parkinson's disease progress so much differently in different patients?
Time of Update: 2022-10-13
Therefore, in the next experiments, the researchers injected a superoxide fluorescent probe (DHE) into mice abdominally based on the above model to explore the transmission pathway of neuron overactivation → peroxide production →α-Syn. The study found that in the over-activated side of the brain of neurons, there was also an increase in superoxide signaling and an increase in the spread of human-derived α-Syn, and the nitrolification level of human-α-Syn was also significantly improved.
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Clinical-anatomical syndrome category of autoimmune encephalitis Knowledge card
Time of Update: 2022-10-13
2 Figure 3 table teaches you the diagnosis of autoimmune encephalitis chart summaryGuideIn 2019, Xiaobian launched the "Knowledge Card" column, which organizes some clinical disease-related knowledge points in the form of simple and easy-to-save tables, so that clinicians can use fragmented time to learn from the past, which is quite popular with doctor readers!
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How is co-infection with coronary heart disease and ischemic stroke assessed? Take a look at the latest expert consensus
Time of Update: 2022-10-13
Coronary heart disease and ischemic stroke co-assessment is to prevent the recurrence of cardiovascular events in patients with cardio-cerebral comorbidities, and primary medical institutions should focus on the patient's condition assessment and risk assessment of recurrent cardiovascular events, and the problems found should be referred in time.
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How much do you know about the 10 symptoms of early-onset Alzheimer's disease?
Time of Update: 2022-10-13
AD is a progressive disease that causes memory problems and various associated symptoms, which means symptoms worsen over time, and it is the most common type of dementia.
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Heavy! The first "Guidelines for the Diagnosis and Treatment of Cluster Headache in China" was released, and the key points of diagnosis and treatment were at a glance!
Time of Update: 2022-10-13
2. Indicators of the effectiveness of transitional therapy: (1) frequency of episodes of CH; (2) Duration of headache; (3) The degree of headache; (4) The number of times the drug is used in the acute stage of the attack; (5) Cluster period time.
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Science The point of divergence between modern humans and ancient human nerves: TKTL1
Time of Update: 2022-10-13
Huttner research group at the Max Planck Institute for Molecular Cell Biology and Genetics in Germany published an article in Science titled Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals, Important different effects of TKTL1 single amino acid on activity in the transketosolase family were found on large-scale neurogenesis in modern humans and ancient humans.
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Sacroneuromodulation may be effective for neurogenic lower urinary tract dysfunction
Time of Update: 2022-10-13
For non-neurogenic lower urinary tract dysfunction (non-NLUTD), sacral neuromodulation (SNM) is a mature therapy.
For non-neurogenic lower urinary tract dysfunction (non-NLUTD), sacral neuromodulation (SNM) is a mature therapy.
For non-neurogenic lower urinary tract dysfunction (non-NLUTD), sacral neuromodulation (SNM) is a mature therapy.
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Is Alzheimer's disease a brain disease? Toronto General Hospital proposed a new hypothesis
Time of Update: 2022-10-13
There have been many opinions about the pathogenesis of Alzheimer's disease, and the "β amyloid" hypothesis, which attracted the most attention, fell off the altar in Science's falsification of the 2
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Is the diagnosis of coma difficult to diagnose? 5 key points to clarify the idea!
Time of Update: 2022-10-13
Coma refers to the pathological process in which the higher neural central structure and functional activities (consciousness, sensation and movement) are in a severe and widely suppressed state caused by various etiologies, and is a serious impairment of consciousness, manifested as the continuous interruption or complete loss of some or all of consciousness, which is one of the main manifestations of brain failure.
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NEJM (IF=176) The latest advances in the treatment of frostbite! Phase 3 clinical results of antisense oligonucleotides in the treatment of frostbite suggest that its efficacy remains to be evaluated
Time of Update: 2022-10-13
Overall, in patients with amyotrophic lateral sclerosis of type SOD1, within 28 weeks, Tofersen reduced the concentration of SOD1 in the cerebrospinal fluid and the neurofilamentin light chains in plasma, but did not improve clinical endpoints and was associated with adverse events.
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Have you brushed your teeth properly? New research suggests that oral diseases can trigger Alzheimer's disease
Time of Update: 2022-10-13
Recently, researchers reported the link between gum disease and Alzheimer's disease in the Journal of Alzheimer's Disease, and made new discoveries about the interaction of ganga porphyrin monas with two important pathological lesions in the brains of Alzheimer's patients, namely β amyloid plaque (Aβ) and Tau protein hyperphosphorylation caused by neurofibrillary tangles.
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Nature: Why does infection make people have no love? The relevant neurons have finally been found!
Time of Update: 2022-10-13
。After LPS injection, the activation of neurons in the dorsal complex of the brainstem vagus nerve in mice was remarkableTo clarify the role of NTS and AP in post-infection disease behavior, the researchers injected AAV-DIO-Gq-mCherry into the NTS-AP region of TRAP2 mice (expressing triphenoxylamine-induced Cre recombinase that knocks into the Fos gene locus).
