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JNNP—Wei Qiu/Qingfen Yu team discovers susceptibility genes for diseases in the familial neuromyelitis lineage
Time of Update: 2022-10-03
, JNNP, 2022) Conclusion and discussion, inspiration and outlookIn summary, the study combined with clinical genetics, bioinformatics and statistics to describe the clinical manifestations of familial NMOSD as a rare disease, revealed its possible pathogenic genes, and suggested that non-rare mutations in the promoter, enhancer and transcription factor binding site of the USP18 gene affected the expression of the USP18 gene and impaired its molecular function as a negative feedback regulator in the JAK/STAT signaling pathway.
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[Neurology] Shanghai Jiaotong Yingli team found that these seven healthy living habits can reduce the risk of dementia in diabetic patients
Time of Update: 2022-10-03
According to a study published in the journal Neurology on September 14, 2022, a combination of seven healthy lifestyle habits, including sleeping seven to nine hours a day, regular exercise and frequent social contact, was associated with a lower risk of dementia in people with type 2 diabetes.
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Nat Metab-Xiong Wei's research group elucidated a new target for motor toxicity caused by the synergy of alcohol and marijuana
Time of Update: 2022-10-03
Written by - Zou Guichang, Xiong Wei, eds. - Sizhen Wang, Editor - Yang Binwei's psychoactive drugs such as tetrahydrocannabinol (THC) and alcohol have been widely reported to impair motor coordinatio
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How do status epileptic seizures stop? Take a look at the latest Chinese expert consensus
Time of Update: 2022-10-03
(3) Dosage: Adult SE intravenous administration can consider the first dose of 10~20mg intravenous slow bolus; If ineffective, intravenous bolus can be re-injected after 5 minutes; If effective (seizures stop), intravenous infusion (12 h) with 80 to 100 mg of diazepam in 5% glucose solution; If the medication is effective, but the recurrence is maintained, 10 to 20 mg of diazepam can be reinjected; If treatment is ineffective, the drug should be discontinued and replaced with other recommended drugs.
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The adult brain also has new neurons
Time of Update: 2022-10-03
One of the authors of the new evidence on neurogenesis in adulthood published in the journal Nature, Hongjun Song said: "Everyone uses the same methodology, histology, and antibodies to detect cells, which leads to them actually studying very few proteins, which may not be equally suitable for tissues.
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JAMA: Three benefits of walking 10,000 steps a day! Nearly 80,000 people have been followed up for 7 years, showing that walking 10,000 steps a day can reduce the risk of deaths from cancer and cardiovascular diseases, and also prevent dementia
Time of Update: 2022-10-03
com/product/ax3[4] _msthash="251375" _msttexthash="4901572">[5] _msthash="251376" _msttexthash="8517626">The author of this article Zhang Eddie*For medical professionals onlyWith the emergence of a variety of wearable health smart devices, walking steps have become a project that people are secretly competing for.
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Diagnosing tension-type headaches requires "think twice" and then act, and "think twice" means...
Time of Update: 2022-10-03
[1,6Table 2 TTH diagnostic criteria (ICHD-3)[1]Think twice: Is the differential diagnosis of TTH well remembered?TTH needs to be distinguished from new daily persistent headache (NDPH), headache due to somatization disorder, medication overuse headache (MOH), and other primary headaches.
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Science for the first time in the world! ShanghaiTech University Huatian/Liu Zhijie unveils the "mystery" of bitter taste receptors
Time of Update: 2022-10-03
Artistic display of the bitter receptor TAS2R46 expressed by different bitter molecules on the taste buds (Julie Liu) TAS2R with other GPCRs shows low sequence identity (—END—The content is [iNature]iNatureTaste perception is a complex chemical sensing process mediated by type 2 taste receptors (TAS2Rs) or T-G protein-coupled receptors.
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Molecular Psychiatry's team resolved the neural circuits in which fear enhances the shock reflex
Time of Update: 2022-10-03
The specific projection of 5-HT neurons in DRN to GABAergic neurons in RtTg is synthesis, and this study analyzes the neural circuits and molecular mechanisms of fear enhancing the shock reflex from the dimensions of loop identification, neuron type analysis, transmitter type judgment and downstream receptor subtypes (Figure 3), and the results deepen our understanding of the neural mechanism of advanced emotion regulation instinctive defense behavior.
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Speech disadvantage + dysarthria, don't just think of cerebral infarction!
Time of Update: 2022-10-03
Neurologic examination:Confusion, dysarthria, atrophy and fibrillation of the tongue muscles, decreased gag reflex, positive mandibular reflex, perioral reflex, and left palmomandibular reflex;Right sternocleidomastoid muscle, bilateral trapezius reflex, bilateral deltoid reflex positive, bilateral biceps tendon reflex, triceps tendon reflex and bilateral radioperiosteal reflex, positive bilateral fascial spinal and bilateral rectus reflexes, positive bilateral gluteus maximus reflexes, bilateral knee tendon reflexes and Achilles tendon reflexes, ankle-clonic (+), positive bilateral pathological signs.
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Nat Metab Xiong Wei's team reveals the neural mechanisms by which alcohol-cannabis synergy leads to motor disorders
Time of Update: 2022-10-03
Illustration: Schematic diagram of alcohol and cannabinoids synergistically causing dyskinesiaOriginal link: Maker: ElevenReprint Notice【Non-original article】The copyright of this article belongs to the author of the article, welcome individuals to forward and share, without the author's permission is prohibited from reprinting, the author has all legal rights, violators will be prosecuted.
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Multidimensional thinking on factors influencing therapeutic efficacy of spinal muscular dystrophy disease correction
Time of Update: 2022-10-03
With the advent of more and more drugs and their advancement in clinical application, the diagnosis and treatment of SMA has begun to face new problems and challenges, including how to correctly understand the treatment benefits of patients of different ages and course of disease presented in clinical practice, what are the relevant influencing factors of disease revision therapy (DMT) efficacy in the real world, and whether we can predict the efficacy of treatment in the future.
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How does the KRAS gene-targeting drug AMG510 control brain lesions?
Time of Update: 2022-10-03
In June 2021, the patient began oral administration of 960 mg of AMG510 per day, and after 6 weeks of administration, the patient's lung lesions and new metastatic lesions of the brain that had not yet been treated showed a good response, which lasted for 5 months.
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How do dogs see the world? Human researchers want to decode visual cognition in the dog's brain
Time of Update: 2022-10-03
At the same time, machine learning techniques are advancing, allowing scientists to decode some of the patterns of activity in the human brain.
At the same time, machine learning techniques are advancing, allowing scientists to decode some of the patterns of activity in the human brain.
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Roundup: The "power" of lipids that should not be underestimated! Brain lipomics: from function to disease
Time of Update: 2022-10-03
8, eadc9317 (2022), Brain lipidomics: From functional landscape toclinical significanceThe images in the article are from referencesClick on the blue letter to follow usLipids are the main components of cell membranes and are mainly synthesized by enzymes in the endoplasmic reticulum.
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Potential cure for ear diseases, a number of AAV gene therapies are poised to develop
Time of Update: 2022-10-03
September 18, 2022 / eMedClub News/-September 13, 2022, Akouos announced that its gene therapy AK-OTOF, which is used to treat Otoferlin gene (OTOF)-mediated hearing loss, has been approved by the FDA
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Current Biology: Parathyroid hormone hormone circuits that regulate social hair grooming
Time of Update: 2022-10-03
Figure 3: PIL ➟MPOA peptide energy loop regulates hair management behaviorsummaryIn this paper, through viral tracing and chemical genetics, we revealed the peptide-capable neural circuits that regulate the social hair management behavior of female rats: posterior medial nuclei expressing PTH2-positive neurons projected onto the medial preoptic region inhibitory neurons.
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【Science sub-journal】Break the traditional concept! Luo Donggen's team at Peking University discovered a new mechanism for maintaining circadian rhythms
Time of Update: 2022-10-03
This article is the original of the translational medicine network, please indicate the source when reprinting Author: SophiaCircadian rhythms are coordinated by the brain's main clock and operate fre
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How can Alzheimer's disease be prevented? The Doctor of the Huashan Divine Inside has arrived
Time of Update: 2022-10-03
e. , childhood and adolescence), the risk factors for intervening are mainly low levels of education;In middle age, a history of elevated blood pressure, obesity, hearing loss, excessive alcohol consumption, and brain trauma correlates with the risk of AD, which can reduce the risk of AD if controlled;Later in life (>65 years of age), AD-related interoperable risk factors include smoking, depression, physical inactivity, reduced social support, diabetes, and air pollution.
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Nature Medicine: Breakthrough in stem cell + gene therapy for frostbite!
Time of Update: 2022-10-03
They conducted their first human clinical trial using this engineered neural progenitor cell (CNS10-NPC-GDNF), and through a 12-month clinical Phase 1/2a trial, as well as follow-up results from patients, they found that the new therapy was safe for ALS patients.
