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PloS Genet—Lingyan Xing/Liucheng Wu/Junjie Sun collaborated to reveal a new mechanism of noncellular autonomic degeneration of motor neurons in spinal muscular atrophy
Time of Update: 2022-10-03
Written by - Sun Junjie Responsible Editor - Wang Sizhen Editor - Yang Binwei spinal muscular atrophy (SMA) is a common fatal genetic disorder in children, the most important pathological features are motor neuron degeneration in the anterior corner of the spinal cord and neuromuscular joint necrosis.
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Science sub-journal: Alzheimer's disease antibody therapy innovation! An Zhiqiang's team developed a quadrivalent TREM2 agonist antibody
Time of Update: 2022-10-03
Ab18 TVD-Ig/αTfR enhances cognitive function in AD-mode miceOverall, this study shows that through antibody engineering combined with TfR-mediated brain delivery, multivalent TREM2 agonist antibodies that can pass through the blood-brain barrier can be obtained, which strengthens microglial function, reduces Aβ pathological deposition, and promotes the development of clinically effective therapeutic measures targeting TREM2.
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How can Alzheimer's disease be prevented? The Doctor of the Huashan Divine Inside has arrived
Time of Update: 2022-10-03
e. , childhood and adolescence), the risk factors for intervening are mainly low levels of education;In middle age, a history of elevated blood pressure, obesity, hearing loss, excessive alcohol consumption, and brain trauma correlates with the risk of AD, which can reduce the risk of AD if controlled;Later in life (>65 years of age), AD-related interoperable risk factors include smoking, depression, physical inactivity, reduced social support, diabetes, and air pollution.
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Current Biology: Parathyroid hormone hormone circuits that regulate social hair grooming
Time of Update: 2022-10-03
Figure 3: PIL ➟MPOA peptide energy loop regulates hair management behaviorsummaryIn this paper, through viral tracing and chemical genetics, we revealed the peptide-capable neural circuits that regulate the social hair management behavior of female rats: posterior medial nuclei expressing PTH2-positive neurons projected onto the medial preoptic region inhibitory neurons.
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【Science sub-journal】Break the traditional concept! Luo Donggen's team at Peking University discovered a new mechanism for maintaining circadian rhythms
Time of Update: 2022-10-03
This article is the original of the translational medicine network, please indicate the source when reprinting Author: SophiaCircadian rhythms are coordinated by the brain's main clock and operate fre
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Potential cure for ear diseases, a number of AAV gene therapies are poised to develop
Time of Update: 2022-10-03
September 18, 2022 / eMedClub News/-September 13, 2022, Akouos announced that its gene therapy AK-OTOF, which is used to treat Otoferlin gene (OTOF)-mediated hearing loss, has been approved by the FDA
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Nature Medicine: Breakthrough in stem cell + gene therapy for frostbite!
Time of Update: 2022-10-03
They conducted their first human clinical trial using this engineered neural progenitor cell (CNS10-NPC-GDNF), and through a 12-month clinical Phase 1/2a trial, as well as follow-up results from patients, they found that the new therapy was safe for ALS patients.
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Medical interview with Professor Li Yang: High-risk neuroblastoma treatment is difficult, comprehensive treatment, innovative drug technology to improve the survival of children
Time of Update: 2022-10-03
At present, the Department of Oncology and the Department of Hematopoietic Stem Cell Transplantation of the Children's Medical Center of Sun Yat-sen Memorial Hospital of Sun Yat-sen University have innovatively used arsenic trioxide (As2O3) combined chemotherapy and allo-HSCT to treat children with relapsed refractory high-risk NB after preliminary research and exploration, which has shown obvious efficacy advantages over traditional treatment.
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Which lesion should pay for persistent unrelieved dizziness?
Time of Update: 2022-10-03
*For medical professionals only, if you want to solve the mystery, you must first understand the conduction pathway of the vestibular nerveSummary of medical recordsA 54-year-old woman with a history of previous diabetes was admitted to the hospital on May 17, 2022 with the main complaint of "dizziness for 19 hours, aggravated for 2 hours", accompanied by nausea and vomiting, no rotation of vision, blurred vision, no tinnitus, hearing loss, no difficulty swallowing, drinking water and cough.
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Monkeypox is associated with encephalitis, insanity, and seizures| forward express
Time of Update: 2022-10-03
Recently, a systematic review and meta-analysis showed preliminary evidence that monkeypox is associated with neuropsychiatric complications, including encephalitis, confusion, and seizures.
Recently, a systematic review and meta-analysis showed preliminary evidence that monkeypox is associated with neuropsychiatric complications, including encephalitis, confusion, and seizures.
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"Neurology": do housework, visit relatives and friends, prevent dementia! The West China team analyzed 10-year data of more than 500,000 people and found that doing housework and visiting relatives and friends were associated with a 21% and 15% reduction in the risk of dementia, respectively
Time of Update: 2022-10-03
Recently, the research team of Professor Song Huan from West China Hospital of Sichuan University published prospective research results based on the association between physical and mental activity and dementia in the British Biobank cohort in the journal Neurology[1].
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The study found that people who become fathers for the first time may atrophy the cerebral cortex?
Time of Update: 2022-10-03
Recommended Live/Events09/27 14:00-17:30 ShanghaiInnovative technology to facilitate the summit forum on accurate diagnosis and treatment of tumorsScan the code to participate for freeNovember 03-04 09:00-17:30 ShanghaiThe 3rd Yangtze River Delta In Vitro Diagnostic Industry ForumScan the code to participate for freeNovember 11-25 27:09-00:17 ShanghaiThe 4th Shanghai International Cancer CongressScan the code to participateBecoming a new parent is a challenge for both men and women.
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Your brain can control appetite! Science: The brain can talk directly to fat
Time of Update: 2022-10-03
The new study, published September 7, 2022 in the journal Nature, raises the possibility of human interference with this gut-brain connection to help the brain make unhealthy food choices and could address the growing global health crisis caused by overeating (Figure 1).
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Heavy! The latest expert consensus on the diagnosis and treatment of amyotrophic lateral sclerosis was released
Time of Update: 2022-10-03
Amyotrophic lateral sclerosis (ALS) is the most common type of motor neuron disease, the general incidence of middle-aged and elderly people is more common, the peak of ALS onset age in China is about 50 years old, and the age of onset has a younger trend, a small number of patients can be about 20 years old to become ill.
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Brain: "I want to lose weight", intestines: "No, you don't want to"! Nature reveals the secrets of fat addiction
Time of Update: 2022-10-03
Experimental data showed that blocking CCK (cholecystin) signaling eliminates all reactions of vagus nerve sugar/fat neurons, that is, CCK is a transmitter that mediates intestinal-brain axis trophic sensing.
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Tirofiban is not effective in patients with acute stroke who undergo thrombectomy
Time of Update: 2022-10-03
A significant proportion of patients with acute ischemic stroke with large vascular occlusion continue to develop disability after undergoing endovascular thrombosis (EVT), and it is unclear whether adjunctive antithrombotic use helps improve outcomes.
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Symptomatic intracranial artery stenosis, what is the advantage or disadvantage of medication and stent combined with medication? China's latest research is coming!
Time of Update: 2022-10-03
On August 10, 2022, a Chinese team study published in JAMA compared two treatment options for patients with symptomatic intracranial artery stenosis, showing that there was no significant difference in efficacy between stent combination drug therapy and pharmacotherapy alone on symptomatic intracranial atherosclerotic stenosis.
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Neuron—A new molecular mechanism by which synaptic initiating proteins regulate ultrafast endocytosis
Time of Update: 2022-10-03
Written by - Wang Yalong Responsible Editor - Wang Sizhen Editor - Yang BinweiThe continuous neural activity of neurons requires the participation of a large number of synaptic vesicles, and the cell body cannot replenish the consumed vesicles in time, so a variety of vesicle circulation methods are formed within the synapses to ensure the rapid recovery of the membrane and protein components of the synaptic vesicles for reuse[1].
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Is there so much story behind the battle over the diagnostic criteria for Alzheimer's disease?
Time of Update: 2022-10-03
*For medical professionals onlyWhat are the diagnostic criteria for Alzheimer's disease? Since the beginning of the 19th century, named Alzheimer's disease (AD) after German professor Alois Alzheimer,
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Neurology: Application of MRI metabolomics in idiopathic intracranial hypertension to identify markers of disease and headache
Time of Update: 2022-10-02
Using proton magnetic resonance spectroscopy, they used non-targeted metabolomics methods to determine quantitative differences in metabolites in CSF, serum, and urine in active IIH participants, and compared them with control groups that matched age, sex, and body mass index (BMI).
