Written by Chang Yanyu

Responsible editor - Wang Sizhen

Editor—Binwei Yang

Neuromyelitis Optica Spectrum Disorders (NMOSD) is an autoimmune disease of the central nervous system that tends to occur in young and middle-aged women in Asia, characterized by recurrent optic neuritis, myelitis and inflammation damage at other specific locations in the skull, with severe symptoms each recurrence and may leave irreversible neurological disability with a high rate of disability.
It is one of
the important factors of non-traumatic disability in China's young and middle-aged population.

Autoimmune antibodies to Aquaporin 4 (AQP4) play an important role
in its onset.

The current incidence of NMOSD worldwide is about 0.
3 to 4.
4 per 100,000 people
.

Most cases of NMOSD are sporadic cases, but about 3% of NMOSD cases are characterized by
family clusters.

Familial cluster seizures and high incidence in Asian populations suggest that genetic factors play an important role
in the pathogenesis of NMOSD.

However, there is still a lack
of research on the genetic background of NMOSD, especially familial NMOSD.

On September 1, 2022, the team of Wei Qiu and Qingfen Yu of the Third Affiliated Hospital of Sun Yat-sen University published a report in the Journal of Neurology, Neurosurgery and Psychiatry (JNNP) titled "Clinical and genetic analysis of familial neuromyelitis optica spectrum disorder in.
" Chinese: associated with ubiquitin-specific peptidase USP18 gene variants" article explains the clinical characteristics of familial NMOSD patients in China, as well as the possibility that SNP rs2252257 polymorphisms located on the promoter and enhancer region of ubiquitin-specific peptidase USP18 gene may be involved in familial NMOSD pathogenesis
.

Original link: https://jnnp.

Corresponding authors: Qiu Wei (left), Yu Qingfen (right)

About the Corresponding Author (Swipe Up and Down to Read)

Qiu Wei is the assistant dean of the Third Affiliated Hospital of Sun Yat-sen University, the deputy director of the Department of Neurology, the director of the Office of the Encephalopathy Center, a professor, a chief physician, and a doctoral supervisor
.

Yu Qingfen, Associate Researcher of the Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Master Supervisor, Young Academic Backbone
of Sun Yat-sen University's "Hundred Talents Program".

2016 German Yulich Research Center Master Supervisor; In 2022, he is a member of the first committee of
the Guangdong-Hong Kong-Macao University Psychiatric and Neurological Disease Alliance.

His main research interests are the pathogenic mechanism of protein nucleic acids by molecular dynamics simulation, the wrapping mechanism of nanoparticles and cell membranes by finite element analysis, and the mechanism
of action of gene proteins by multi-omics sequencing analysis.

He has published more than 10 SCI articles and works, including 3 first-author articles, 2 co-authors and reports, 1 co-corresponding author, 2 impact factor IF>10, 3 JCR District 1 of the Chinese Academy of Sciences, and published academic journals such as Nano Lett.
, Nanoscale, J Phys.
Chem.
B.
etc
.

He has participated in the EU Horizon Project CompBioMed, the EU FP7 NMP cooperation project PreNanoTox, and the National Construction of High-level University Public Postgraduate Program
.

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