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JAMA Netw Open: Do these two points well, and the risk of all-cause death in Parkinson's disease patients has plummeted by 65%!
Time of Update: 2022-10-08
Therefore, this study aimed to explore the pre- and post-diagnostic overall dietary quality and physical activity and all-cause mortality in PD patients from 2 large US cohorts, the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS)) relationship .
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Annals of neurology: Plasma pTau181 is elevated in ALS
Time of Update: 2022-10-08
A recent study by our group tested the diagnostic accuracy of plasma p-tau181 in AD, but unexpectedly found high levels of p-tau181 in 11 patients with amyotrophic lateral sclerosis (ALS), a A neurodegenerative disorder involving upper motor neuron (UMN) and lower motor neuron (LMN) disease .
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JNNP: Systematic Review of ALS Gene Mutations, a Population-Based Study
Time of Update: 2022-10-08
Therefore, this study systematically analyzed a population-based cohort of ALS patients using whole-genome sequencing .
Therefore, this study systematically analyzed a population-based cohort of ALS patients using whole-genome sequencing .
Therefore, this study systematically analyzed a population-based cohort of ALS patients using whole-genome sequencing .
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NNP: Doxycycline in Neuropathic Lyme Disease, a Multicenter, Double-Blind, Randomized and Placebo-Controlled Trial
Time of Update: 2022-10-08
This article aims to compare the efficacy and safety of oral doxycycline treatment with the LNB in Europe in a randomized controlled trial over several weeks .
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Persistently low wages linked to accelerated memory decline later in life, study finds
Time of Update: 2022-10-08
Although these health problems increase the risk of cognitive decline in old age, no studies have linked low wages directly to cognitive decline in later life .
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Neurology: short-term and long-term central effects of botulinum toxin in the treatment of laryngeal dystonia
Time of Update: 2022-10-08
A recent study published in Neurology sought to investigate the short- and long-term effects of BoNT treatment on brain function in patients with LD .
A recent study published in Neurology sought to investigate the short- and long-term effects of BoNT treatment on brain function in patients with LD .
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Neurology: Effects of oral anticoagulation and adenosine diphosphate inhibitor therapy on short-term efficacy of traumatic brain injury
Time of Update: 2022-10-08
Recently, a study published in Neurology sought to investigate the effect of OAC and ADPI therapy on short-term outcomes after traumatic brain injury .
Recently, a study published in Neurology sought to investigate the effect of OAC and ADPI therapy on short-term outcomes after traumatic brain injury .
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Neurology: Longitudinal effects of combined antiretroviral therapy on cognitive function and neuroimaging markers in HIV-naïve patients
Time of Update: 2022-10-08
A study published in Neurology sought to determine the effect of cART on cognitive and neuroimaging biomarkers in HIV (PWH) patients before and after initiation of cART, compared with HIV negative controls (HC) and HIV elite controllers.
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JNNP: Genotype-phenotype correlations in valosin-containing diseases
Time of Update: 2022-10-08
Sign/symptom frequency between the two most common variantsIn 2004, six missense pathogenic variants were identified in patients with the triad of myopathy, PDB, and FTD, and the VCP gene was found to be the cause of IBMPFD .
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Association of carotid vulnerable plaque with cerebral small vessel disease and acute ischemic stroke in European Radiology
Time of Update: 2022-10-08
Carotid vulnerable plaque coexisting with cerebral small vessel disease and acute ischemic stroke: a Chinese Atherosclerosis Risk Evaluation study.
Carotid vulnerable plaque coexisting with cerebral small vessel disease and acute ischemic stroke: a Chinese Atherosclerosis Risk Evaluation study.
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PNAS︱Li Gang's research group mapped the developmental pattern and regionalization of infant cerebral cortex surface area
Time of Update: 2022-10-06
On August 8, 2022, the research group of Professor Gang Li from the University of North Carolina at Chapel Hill published a paper entitled "Mapping developmental regionalization and patterns of cortical surface area from the Proceedings of the National Academy of Sciences (PNAS)".
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Front Mol Neurosci-Jun Chen's research group revealed that secondary nerve injury and neuroinflammation in the dorsal horn of the spinal cord mediate post-thalamus hemorrhagic post-stroke pain
Time of Update: 2022-10-06
In this study, it was found that neuronal damage and inflammation in the primary site of thalamus hemorrhagic stroke were retrograde ulcerated through STT, resulting in the death of STT projection neuron cells in the dorsal horn of the spinal cord, thereby inducing secondary neuroinflammation and neuronal hyperexcitation, which in turn was easy to dissolve the spinal cord flexor reflex and appear mechanical pain sensitivity.
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Sun Yat-sen University Ye Xiaojing's team revealed that stress is more likely to cause female meningeal lymphatic disorder
Time of Update: 2022-10-06
The expression of LYVE1 protein in the superior sagittal sinus and transverse sinus of the dura mater of stressed female mice was increased after injection of VEGFC virus overexpressed, the function of meningeal lymphatic vessels was enhanced, and depression-like behaviors were effectively improved .
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Tsinghua Guo Zengcai's team reveals the asymmetric interaction between the left and right hemispheres of short-term memory Cell Press Paper Express
Time of Update: 2022-10-06
life scienceslife scienceOn August 16, 2022, Tsinghua University School of Medicine, Tsinghua-Peking University Life Science Joint Center, Tsinghua-IDG/McGovern Institute for Brain Science Guo Zengcai's research group published a long article in Cell Reports titled "Left and right hemispheres are short.
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Compound aspertide injection for the treatment of acute ischemic stroke in 400 cases: a multicenter retrospective study
Time of Update: 2022-10-06
Methods: From November 2017 to November 2018, 400 patients with acute IS admitted to nine hospitals, including the Second Affiliated Hospital of Hebei Medical University, were selected as the study subjects, and on the basis of conventional treatment, 203 cases were divided into experimental group (compound astripeptide injection + conventional treatment), 85 cases in the control group (other gangliosides + conventional treatment) and 112 cases in the blank group (conventional treatment) according to the different combination drugs.
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Electric shock to the brain can really improve memory, netizens read the online Nature sub-issue
Time of Update: 2022-10-06
Specific to the experimental method, the researchers selected 150 elderly people aged 65 to 88, randomly divided them into groups of 20, and applied 60Hz high-frequency gamma waves and 4Hz low-frequency theta waves to the human brain alternately The prefrontal cortex (DLPFC) and the inferior parietal cortex (IPL) are two key parts of memory in the brain .
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Aging Cell︱Xiao Jianhui's team reports a potential anti-aging drug: Ganoderma lucidate D activates the CaM/CaMKII/NRF2 signaling axis to delay stem cell aging
Time of Update: 2022-10-06
On August 5, 2022, the team of Professor Jianhui Xiao from the Affiliated Hospital of Zunyi Medical University published a paper entitled "Ganoderic acid D prevents oxidative stress-induced senescence by targeting 14-3-3ε to activate CaM/CaMKII/NRF2 signaling pathway on Aging Cell.
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Nat Commun Ye Xiaojing/Lin Weijie/Zhang Yan reveal the important role of meningeal lymphatic vessels in the regulation of sex differences in stress susceptibility
Time of Update: 2022-10-06
In a research paper in mice, the article found that sex-differentiated damage to meningeal lymphatic vessels caused by repeated stress is a key factor in the differential production of depression-like and anxiety-like phenotypes between males and females .
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Brain: Chinese scientists have revealed for the first time the changes in adult cerebrospinal fluid and imaging AD biomarkers over time
Time of Update: 2022-10-03
0055); The annual rate of change of the Aβ42/Aβ40 ratio showed an accelerated decline in the 45-50 years and 65-70 years (P In the PET PiB cohort, both the mean cortex and the anterior wedge SUVR were in the baseline age 50-55 years range, and for the first time significantly accelerated increases were observed (P the 65-70 age range.
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How do status epileptic seizures stop? Take a look at the latest Chinese expert consensus
Time of Update: 2022-10-03
(3) Dosage: Adult SE intravenous administration can consider the first dose of 10~20mg intravenous slow bolus; If ineffective, intravenous bolus can be re-injected after 5 minutes; If effective (seizures stop), intravenous infusion (12 h) with 80 to 100 mg of diazepam in 5% glucose solution; If the medication is effective, but the recurrence is maintained, 10 to 20 mg of diazepam can be reinjected; If treatment is ineffective, the drug should be discontinued and replaced with other recommended drugs.
