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NNP: Doxycycline in Neuropathic Lyme Disease, a Multicenter, Double-Blind, Randomized and Placebo-Controlled Trial

 Last Update: 2022-10-08
 Source: Internet
 Author: User

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Lyme disease neuropathic (LNB) usually presents with painful meningeal radiculitis and/or cranial neuritis with discomfort and fatigue

Recommendations regarding the duration of treatment are divided

The trial was randomized, double-blind, placebo-controlled

Research Process

Secondary endpoints were CCS at 10 weeks and 12 months, CSF results at 6 months and 12 months, safety measured by blood tests (hematology values, kidney and liver function) at 2 months and 4 months Patients reported outcome measures (PROMs) and weekly reported side effects in a 10-week patient diary a few weeks after initiation of sexual and tolerable therapy

Combined clinical scores for both treatment groups throughout the study

A total of 121 patients were included

The results showed no benefit of doxycycline treatment beyond 2 weeks

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