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Lifestyle behaviors, including diet and physical activity, are associated with the risk of developing Parkinson's disease (PD), the second most common neurodegenerative disease
Despite improvements in the clinical management of motor symptoms in PD, there is little evidence that current treatments can slow progressive neuronal loss
This population-based cohort study analyzed male participants in the Health Professionals Follow-up Study 1986-2012 and female participants in the Nurses' Health Study 1984-2012
Among 1251 PD patients, 652 (52.
Similar results were obtained for cumulative mean MET hours per week in pre-diagnosis analysis (HR, 0.
In a combined analysis of diet quality and physical activity before PD diagnosis, the adjusted HR for individuals with the highest and lowest third-order gradients for both variables was 0.
This cohort study is the largest study to date to investigate the relationship between overall diet quality and physical activity and survival in PD patients in a future cohort
Overall, healthy dietary patterns and active lifestyles were associated with reduced all-cause mortality in PD patients
Original source:
Zhang X, Molsberry SA, Schwarzschild MA, Ascherio A, Gao X.