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Nature sub-journal: "Exchange blood method" is feasible to treat Alzheimer's disease!
Time of Update: 2022-10-09
Recently, a study titled "Preventive and therapeutic reduction of amyloid deposition and behavioral impairments in a model of Alzheimer's disease by whole blood exchange" published in Molecular Psychiatry, a sub-journal of Nature, showed that by exchanging whole blood with healthy mice, The formation of amyloid plaques in the brains of mice with AD was significantly reduced by 40-80%, suggesting that exchange transfusion therapy may be effective in treating Alzheimer's disease .
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Biomaterials: Novel blood-brain barrier-penetrating nanomaterials for Alzheimer's disease by activating mitophagy
Time of Update: 2022-10-09
In this work, the research team developed a nanoparticle with excellent blood-brain barrier (BBB) permeability composed of Prussian blue/polyamidoamine-type (PAMAM) dendrimer/angiopoietin-2 ( PPA) to restore the physiological function of microglia by regulating mitophagy and scavenging reactive oxygen species (ROS), thereby treating Alzheimer's disease .
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JAHA: A new method for rapid screening of carotid artery stenosis - based on video motion analysis
Time of Update: 2022-10-09
Recently, a research article was published in JAHA, an authoritative journal in the field of cardiovascular diseases, which proposes a novel non-invasive and non-contact detection technology that uses video-based motion analysis (VMA) to extract the subtle pulses from the skin surface.
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Phytomedicine: Dihuang Yin protects dopaminergic neurons in a Parkinson's disease model by reducing peripheral inflammation
Time of Update: 2022-10-09
Conclusions: Although the underlying pharmacological mechanism of DHY is still lacking, this study provides evidence that DHY decoction can protect dopaminergic neurons by reducing peripheral inflammation .
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Neurology: Comparison of efficacy of Ubroxide for mild pain and moderate or severe pain migraine
Time of Update: 2022-10-09
Mild pain was associated with higher rates of 2hPF compared with moderate or severe pain: Ubrosu-50mg (47.
Mild pain was associated with higher rates of 2hPF compared with moderate or severe pain: Ubrosu-50mg (47.
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European Radiology: This sign on ASL predicts brain hyperperfusion after carotid endarterectomy!
Time of Update: 2022-10-09
Recently, a study published in European Radiology evaluated the value of this ATA-based ASL score in predicting cerebral hyperperfusion after CEA in patients with carotid artery stenosis, providing a valuable non-invasive method for clinical preoperative prediction of cerebral hyperperfusion after CEA.
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Zhong Nanshan talks about sleep: about 38% of adults have the problem of insomnia
Time of Update: 2022-10-09
On August 17, at the unveiling ceremony of the Sleep Medicine Center of the First Affiliated Hospital of Guangzhou Medical University, Zhong Nanshan, an academician of the Chinese Academy of Engineering and a well-known expert in pulmonology, said that in China, about 38% of adults have insomnia problems.
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Delay cognitive aging!
Time of Update: 2022-10-09
The research team also exercised veterans with mild cognitive impairment for 6 months and also observed a synergistic increase in plasma CLU levels and improved cognitive memory function .
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Nature communications Transcriptomic analysis to reveal genes associated with selective hippocampal susceptibility in Alzheimer's disease
Time of Update: 2022-10-09
1038/s41467-021 -22399-3 Transcriptomic analysis to reveal genes associated with selective hippocampal susceptibility in Alzheimer's diseaseREADINGAlzheimer's disease (AD)Alzheimer's disease (AD) is a multifactorial neurodegenerative disease characterized by the abnormal accumulation of two misfolded proteins, tau and beta amyloid (Aβ) .
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Neurology: The role of OCT criteria and machine learning in the diagnosis of multiple sclerosis and optic neuritis
Time of Update: 2022-10-09
Recently, a study published in Neurology proposes that machine learning classification may help to validate thresholds for OCT improvised explosive devices, as well as examine the additional utility of tests of visual function, such as low-contrast letter acuity (lCLA), for diagnostic purposes.
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Science: GPNMB may be an important biomarker for Parkinson's disease
Time of Update: 2022-10-09
Computational, cell biology, and human tissue-based studies identified GPNMB as a risk gene and potential therapeutic target for Parkinson's disease (PD), the researchers report .
abk0637 Computational, cell biology, and human tissue-based studies identified GPNMB as a risk gene and potential therapeutic target for Parkinson's disease (PD), the researchers report .
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Neurology: Academician Lu Lin's team finds associations between various daily activities and dementia risk
Time of Update: 2022-10-09
The researchers found that after adjusting for factors such as age, sex, and education, leisure activities were associated with a lower risk of developing all-cause dementia, Alzheimer's disease, and vascular dementia .
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Nature BE: Can paralyzed people walk again?
Time of Update: 2022-10-09
To address the limitations of functional electrical stimulation (FES), the research team succeeded in controlling leg movements in mice using only artificial nerves, without the use of complex and bulky external computers, using stretchable, low-power organic nanowires Neuromorphic devices that mimic the structure and function of biological nerve fibers .
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Front.cellular neurosci-The role of microRNA in astrocytes after stroke
Time of Update: 2022-10-09
In the context of cerebral ischemia, AQP4 has a dual role: it can rapidly cause cerebral edema and brain injury in the early stage of stroke, and the up-regulated expression of AQP4 in the late stage has a clearing effect on angioedema .
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JNNP: Safety of breastfeeding during rituximab treatment in multiple sclerosis
Time of Update: 2022-10-09
There were two other case reports, seven and eight of which reported low concentrations in breast milk, the latter including two serum samples from breastfed infants in which rituximab was not detected .
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Nature: Cerebrospinal fluid from young mice/humans restores oligodendrocyte proliferation and memory in aged mice
Time of Update: 2022-10-09
Recent studies have shown that systemic interventions in organisms have shown great promise in reversing aging-related aspects of brain tissue, such as the transfer of young plasma into the blood of t
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Nat Genet: Large-scale population study finds 72 genes linked to autism
Time of Update: 2022-10-09
"Our findings benefit not only from large-scale, rich data collection in autism research and population genetics studies, but also from newly developed analytical methods that allow us to explore the genetic roots of neurodevelopmental variation in new ways "In addition to the large-scale gene discovery efforts in the field, we are beginning to gain insights into where, when and how these genes play a role in neurodevelopment .
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Nature: This brain cell cooperates with the gut microbiome to fight brain inflammation
Time of Update: 2022-10-08
"The discovery of this anti-inflammatory subpopulation of astrocytes controlled by gut microbes is an important advance in our understanding of CNS inflammation and its regulation," said the researchers .
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Movement disorders: Serum microRNAs predict isolated REM sleep behavior disorder and Lewy body disease
Time of Update: 2022-10-08
, University of Barcelona, Spain, describe the serum miRNA expression profile of a Spanish IRBD cohort without motor and cognitive impairments and isolated by dopamine transporter single-photon emission computed tomography (DaTSPECT) as DaT-negative IRBD, DaT-positive IRBD, IRBD phenolic conversion to PD and DLB and controls .
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Translational Psychiatry: Machine Learning Hints Using EEG to Predict Treatment Response in Major Depressive Disorder
Time of Update: 2022-10-08
Translational Psychiatry volume 12, Article number: 332 (2022) Treatment selection in psychiatry remains a trial-and-error process, and this long-standing clinical challenge has prompted an increasing focus on predictive models of treatment response using machine learning techniques .
