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Stroke is one of the most serious diseases that cause death and disability in adults, and is a major contributor to the global workforce
Astrocytes, a type of glial cell in the central nervous system (CNS) that help maintain brain homeostasis, have been shown in numerous studies to protect the nervous system and improve neurological outcomes
Research result
1.
The BBB can regulate the exchange of substances between the blood and central neurons
Aquaporin 4 is a subtype of aquaporin (AQP) that is predominantly expressed in the brain, particularly at the ends of astrocytes
In addition, AQP4 also plays a role in neuroimmunology
Figure 1.
2.
Inflammation is a series of responses to external and internal stimuli
Figure 2 Three classic inflammatory signaling pathways
3.
Angiogenesis is a progressive process involving increased vascular permeability, degradation of surrounding matrix, proliferation and migration of endothelial cells, and stabilization of newly formed microvessels
4.
Ischemic postconditioning (IPostC) is a therapeutic strategy to modulate and attenuate brain damage in the early stage of ischemia
Furthermore, inhibiting the expression of miR-124 in astrocytes can reduce neuronal apoptosis in vitro and in vivo after ischemic stroke
In conclusion, since the permeability of the blood-brain barrier is increased after stroke, the concentration of miRNA in blood can be used as an indicator for the prognosis of stroke, and it can also help predict the outcome of rehabilitation after stroke, and miRNA can also be used as a diagnostic tool for central nervous system damage.
references
Zhan Zhang Y, Lei L, Zhou H, Lu X, Cai F and Li T (2022) Roles of Micro Ribonucleic Acids in Astrocytes After Cerebral Stroke.
Compilation author: The original beautiful girl (Brainnews creative team)
Reviewer: Simon (Brainnews Editorial Office)
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