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Phytomedicine: Dihuang Yin protects dopaminergic neurons in a Parkinson's disease model by reducing peripheral inflammation

 Last Update: 2022-10-09
 Source: Internet
 Author: User

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Background: Parkinson's disease (PD) is a progressive neurodegenerative disease that poses an increasing threat to human health, and there is still a lack of satisfactory treatments

OBJECTIVE: To verify the therapeutic effect of Chinese herbal formula Dihuangyin (DHY) on PD mouse model, and to explore its potential molecular mechanism

Methods: The effect of DHY on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model was verified by behavioral and histopathological tests

Results: DHY improved motor function and prevented the loss of dopaminergic neurons in an MPTP-induced PD mouse model

Compared with MPTP-intoxicated mice, the number of Th17 cells in splenocytes in DHY group decreased, and the level of IL-17A in serum decreased

Conclusions: Although the underlying pharmacological mechanism of DHY is still lacking, this study provides evidence that DHY decoction can protect dopaminergic neurons by reducing peripheral inflammation

Source:

Wu Y, Liu H, Wang Y, et al.

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