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Roundup: The "power" of lipids that should not be underestimated! Brain lipomics: from function to disease

 Last Update: 2022-10-03
 Source: Internet
 Author: User

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Lipids are the main components of cell membranes and are mainly synthesized by enzymes in the endoplasmic reticulum
.

The main components and functions of brain lipids

Due to the barrier action of the blood-brain barrier, most sterols in the central nervous system are synthesized in situ
.

Figure 1: Brain lipid function

Cerebral lipid disorders and neurodegenerative diseases

Brain lipid metabolism is involved in Alzheimer's amyloid precursor protein (APP) processing, β-amyloid protein (Ab) production, and Ab aggregation
.

summary

Mass spectrometry, immunofluorescence experiments, nuclear magnetic resonance spectroscopy and other techniques are the main research techniques
for the analysis of lipid components.

In recent years, emerging lipiomics technologies have brought the functional research of lipid compounds into a new world
.

In the future, it may be applied to basic medicine and clinical medicine by integrating multiple omics technologies such as lipoomics, metabolomics, proteomics, and transcriptomics
.

【References】

Brain lipidomics: From functional landscape toclinical significance

The images in the article are from references

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