-
Cell "nuclear antenna" cilia-serotonergic axonic synapses drive nuclear signals to alter chromatin accessibility
Time of Update: 2022-10-14
Clapham's team from the Janelia Research Park in the United States published an article titled A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin in the journal Cell on September 1, 2022 In accessibility's article, they demonstrate the synaptic structure between the brainstem serotonergic axons and the primary cilia of hippocampal CA1 pyramidal neurons, which are rich in cilia-limiting serotonin receptor 5-HTR6, which activates the non-classical Gαq/11-RhoA pathway that modulates nuclear actin and increases histone acetylation and chromatin accessibility.
-
Nature: East is not bright and West is bright! Immune activation during pregnancy can blunt adult microglia and strengthen the immunity of star gum
Time of Update: 2022-10-14
1038/s41586-022-05274-zThe images in the article are from referencesClick on the blue letter to follow us1Immunoactivity of adult microglia after early immune stress is lowFigure 1: Early infection causes low activity of adult microglia2Microglial immune activity is low on the following genetic mechanismsFigure 2: MIA model mouse chromatin open region3Passivate the gum, strengthen the star glueFigure 3: Clearance of embryonic stage "passivated" microgliasummary【References】1.
-
Acute motor mutism and encephalopathy in older men Clinical reasoning
Time of Update: 2022-10-14
How should patients with acute motor mutism be targeted for a qualitative diagnosis? Is a history of sickle cell disease instructive in the diagnosis? The latest issue of the Neurology Journal Clinica
-
Nat Commun—Xu Tianle/Li Weiguang/Zhang Siyu teamwork reveals the neuronal cluster organization patterns in which fear and regression memory compete with each other
Time of Update: 2022-10-14
Written by Wang Qi, Li WeiguangResponsible editor - Wang SizhenEditor—NatsubaAs a basic, stable, cross-species conserved emotional memory, fear memory is the memory of an organism's experience of reac
-
Nature Neuroscience: An Important Breakthrough in Parkinson's Disease! Scientists have found that Parkinson's disease "toxic proteins" cause mitochondrial membrane perforation, prompting neuronal death!
Time of Update: 2022-10-14
Horrocks from the University of Edinburgh published the latest research on structural changes in neurons in α-Syn in the leading international journal Nature and Neuroscience.
Horrocks from the University of Edinburgh published the latest research on structural changes in neurons in α-Syn in the leading international journal Nature and Neuroscience.
-
Healthy eating and exercise are associated with reduced mortality from Parkinson's disease
Time of Update: 2022-10-14
The combined effects of diet and exercise on PD-specific mortality were also evident (pre-diagnosis risk ratio, 0.
The combined effects of diet and exercise on PD-specific mortality were also evident (pre-diagnosis risk ratio, 0.
-
Clinical trials have begun on simulated fasting for 5 days a month to alleviate dementia and enhance anti-cancer effects
Time of Update: 2022-10-14
In addition to mouse models, Valter Longo's team conducted a Phase 1 clinical trial of a simulated fasting diet (FMD) in human patients diagnosed with mild cognitive impairment or Alzheimer's disease.
-
Teenagers need to be alert to the risk of this disease after a concussion!
Time of Update: 2022-10-14
conclusion The study included a total of 282 adolescents aged 13 to 18 years (including 111 concussion patients and 171 adolescents who did not suffer concussions), and the researchers assessed the mental health symptoms, including depression and anxiety scores, in the first 28 days after injury.
-
FDA finally approved! The century-old disease, which has a fatality rate of 100%, ushered in innovative therapies
Time of Update: 2022-10-14
To learn more about FDA's approved new drugs, please click on the following image to access our Mini ProgramWuXi AppTec provides integrated, end-to-end new drug development and manufacturing services to the global biopharmaceutical industry, covering the fields of chemical drug development and production, biological research, preclinical testing and clinical trial development, cell and gene therapy development, testing and production.
-
"Science" blockbuster: the treatment of cognitive impairment in patients with Down syndrome, an important breakthrough!
Time of Update: 2022-10-14
Pulsed GnRH therapy improves cognitive performance in patients with Down syndromeOverall, the researchers found and demonstrated for the first time that expression levels of the gonadotropin-releasing hormone GnRH decreased significantly after puberty, and that GnRH levels were closely related to neurological symptoms in patients with Down syndrome, and that GnRH therapy could serve as a treatment direction for Down syndrome.
-
Isolated vertigo within the time window, should venous thrombolysis be considered?
Time of Update: 2022-10-14
According to the existing clinical experience and literature references, if the patient has only vertigo symptoms and no posterior circulatory signs are found on physical examination, the National Institutes of Health Stroke Scale (NIHSS) score may have a low score, and there is no previous history of similar seizures, and no obvious abnormalities in head CT.
-
Neuron: High blood pressure, can't sleep? Scientists have revealed that the pressure-reflex neural circuits that lower blood pressure promote sleep
Time of Update: 2022-10-14
Chronic activation of CART-positive neurons in the NST region is also able to lower blood pressure and heart rate, and promote non-REM sleep.
Chronic activation of CART-positive neurons in the NST region is also able to lower blood pressure and heart rate, and promote non-REM sleep.
-
Accurate diagnosis, early intervention, multi-party cohesion to alleviate the "Alzheimer's dilemma"
Time of Update: 2022-10-14
*For medical professionals onlyPrecise diagnosis and treatment, moving forward the intervention window, or will delay the progression of AD. Alzheimers' disease (AD) is a progressively progressive deg
-
8 pictures teach you to master the basic skills of vertigo
Time of Update: 2022-10-14
Here are 8 mind maps for everyone, involving the international classification of vestibular diseases, the classification of vestibular signs, bedside examination, common vestibular syndrome and the four major laws related to vestibular diseases.
-
After 4 years! "Symptomatic intracranial atherosclerotic stenosis intravascular treatment of Chinese expert consensus 2022" released
Time of Update: 2022-10-14
Restenosis and prevention The risk of asymptomatic restenosis recurrent stroke is relatively low, and follow-up under drug therapy is recommended in principle; Patients with symptomatic severe restenosis who do not respond to pharmacotherapy may be considered for treatment by vascular intervention (C-EO level evidence, moderately recommended).
-
Transl Psychiatry—Accelerated aging of brain function in patients with major depression: evidence from large Chinese participants
Time of Update: 2022-10-14
The study found that patients with MDD had significantly higher Brain-PAD than the control group, a conclusion that was not affected by the age prediction algorithm.
The study found that patients with MDD had significantly higher Brain-PAD than the control group, a conclusion that was not affected by the age prediction algorithm.
-
Studies have found that the distance from auditory language comprehension related brain regions to sensorimotor cortical landmarks predicts language comprehension function
Time of Update: 2022-10-14
Source: Institute of Psychology, Chinese Academy of SciencesThe cerebral areas of the cerebral cortex can be divided into two categories according to their functions: visual, auditory, sensorimotor cortex (mainly processing external single-channel information, such as vision and hearing) and joint cortex (mainly integrating multi-channel information to support memory function).
-
The phase III clinical study of AD new drugs obtained positive results, which can significantly alleviate cognitive decline
Time of Update: 2022-10-14
Figure 1: ArticlePrimary endpoints and critical secondary endpointsAll are statistically significant The Phase III Clinical Clarity AD Study is a global randomized, double-blind, parallel, placebo-controlled study evaluating the clinical efficacy of new agents in 1795 patients with early-stage AD, with the primary endpoint being the clinical dementia score of the Cognitive and Functional Scale (CDR-SB) at 18 months of treatment.
-
Neuropathology—a central brainbank community unit, jointly reported a neuropathology of propionic acidemia
Time of Update: 2022-10-14
After repeated communication between doctors at the three hospitals, on September 14, 2022, the Central Brain Bank Community jointly published an article entitled "Neuropathological report of propionic acidemia" on Neuropathology, which explains the pathological changes in brain tissue in clinically and genetically confirmed PA.
-
J Neuroinflammation—Tang Yamei's team discovered the mechanisms by which pregabalin mitigates microglial activation and neuronal damage in radioactive brain injury
Time of Update: 2022-10-14
Written by - Zhang Zhan, Editor-in-Chief—Sizhen Wang—Xia Ye radiotherapy is an important adjunct treatment for patients with head and neck tumors such as nasopharyngeal carcinoma, primary or metastati
