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The PNAS-Liu team revealed the important role of connexin hemichannels in alleviating neuroinflammation and overexcitability during the onset of temporal lobe epilepsy
Time of Update: 2023-01-05
Written by—Annie Guo, Junyu LiuResponsible editor—Wang Sizhen, Fang YiyiEditor—Summer LeafEpilepsy is one of the most common neurological disorders and manifests as spontaneous and recurrent seizures.
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PNAS: breaks through the blood-brain barrier, targets pathogenic RNA, treats ALS and dementia
Time of Update: 2023-01-05
Written byWang Cong EditorWang Duoyu TypesettingWater WritingAmyotrophic lateral sclerosis (ALS), also known as ALS, is one of the five terminal diseases recognized by the World Health Organization (W
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Clearing the fog of encephalitis ---- eosinophilic meningitis
Time of Update: 2023-01-05
After 1 month of follow-up, the patient had no discomfort, no abnormalities in neurological examination, lumbar puncture cerebrospinal fluid pressure was 220mmH2 O, cerebrospinal fluid routine showed the number of white blood cells 16, cytology: lymphocytic inflammation, no eosinophils.
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A 66-year-old female presents with progressive encephalopathy and bilateral hearing loss in clinical reasoning
Time of Update: 2023-01-05
Patients presenting with encephalopathy and acute/subacute hearing loss may be seen in Susac syndrome, intravascular lymphoma, primary central nervous system vasculitis (PACNS), and schwannomas.
Patients presenting with encephalopathy and acute/subacute hearing loss may be seen in Susac syndrome, intravascular lymphoma, primary central nervous system vasculitis (PACNS), and schwannomas.
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Why does Alzheimer's disease destroy the brain like this? The sub-journal Science reveals the hidden mechanism
Time of Update: 2023-01-05
"We noticed that brain regions with high expression of the APOE gene are closely related to areas where tau protein is tangled and tissue damaged," Professor Gordon said, "Not only the APOE gene, but the 20 genes most closely associated with Alzheimer's disease are expressed in a similar pattern in the temporal lobe.
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In preparation for motherhood, women undergo a series of significant changes in their brains during pregnancy and after childbirth
Time of Update: 2023-01-05
Written byJia Yugeng EditorWang Duoyu TypesettingShui Chengwen pregnancy (pregnancy) can be said to be a very extreme biological process. When a woman transitions to her role as a mother, she undergoe
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[Summary]: Guard the frontier, defend the brain! Physiological and pathological role of mononuclear phagocytes in the brain
Time of Update: 2023-01-05
Tissue-resident macrophages (TRMs) in the brain include microglia (BAMs), which are distributed in the brain parenchyma to support neurogenesis, development, and function, which are located in the CNS boundary region, which mainly play barrier function and immunomodulatory roles.
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Express Durable prevention of multiple sclerosis deterioration, the new generation of therapy has a positive effect
Time of Update: 2023-01-05
▎WuXi AppTec content team editor Immunic, a biopharmaceutical company focused on developing immunotherapies for the treatment of chronic inflammatory and autoimmune diseases, has announced data from a Phase 2 clinical trial of its primary drug candidate, vidofludimus calcium (IMU-838), for the treatment of relapsing-remitting multiple sclerosis (RRMS).
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The three major treatment options for viral meningitis are clearly explained in one article!
Time of Update: 2023-01-05
▼▼▼Click to read the original article to download the AppMost viruses do not have specific antiviral drugs, and treatment of mild viral meningitis with unknown etiology, such as etiology or clinical exclusion of herpes simplex virus (HSV) infection, can be discontinued, mainly symptomatic treatment.
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Science Bulletin Professor Zhanjun Zhang's research team proposed the "frontal lobe retention, temporal lobe damage (FPTI)" hypothesis to analyze the brain mechanism of success and pathological cognitive aging
Time of Update: 2023-01-05
Differences in multidimensional brain structure indexes in success, normal and pathological cognitive aging groupsBased on the large community clinical cohort of BABRI (Alzheimers & Dementia, 2021), the study divided the successful cognitive aging group (SCA), mild cognitive impairment (MCI), and cognitive normal control (CNC) (BMC Geriatrics) according to multidimensional cognitive performance in a large sample population et al.
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Nature Aging Important Progress! Yuan's enhanced team found that intermittent fasting could prevent Alzheimer's disease in mice
Time of Update: 2023-01-05
The failure of these clinical trials suggests that the pathogenesis of AD may be a systemic disease involving multiple pathways or targets, rather than a simple linear cascade effect intermittent fasting (IF) is a popular approach to dietary restriction with multiple benefits for human health, aging, and disease.
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Sudden deafness, how to use glucocorticoids? Know at least these 5 points!
Time of Update: 2023-01-05
Clinical treatment results showed [16], GC+ Ginkgo biloba extract injection can shorten the improvement time of patients' symptoms, effectively reduce the effect of serum endothelin (ET), soluble vascular intercellular adhesion factor-1 (sVCAM-1) and anti-endothelial cell antibody (AECA) levels, and have a good safety profile.
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Cell endoplasmic reticulum stress translates random selection of olfactory receptors on neurons into precise axonal targeting
Time of Update: 2023-01-05
Written by | Yiming In order to accurately and quickly identify odor molecules in the environment, the olfactory sensory neurons (olfactory sensory neurons) of the main olfactory epithelial cells (MOE
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Researchers have published research results on REM sleep staging and cortical regulation
Time of Update: 2023-01-05
On November 18, Liu Danqian's research group of the Center for Excellence in Brain Science and Intelligent Technology (Institute of Neuroscience) of the Chinese Academy of Sciences published a research paper entitled Cortical Regulation of Two-stage Rapid Eye Movement Sleep online in Nature Neuroscience 。 The study revealed and defined for the first time two phases of rapid eye movement sleep (REM sleep) in mice—quiet and active—corresponding to significantly different facial expressions, autonomic activity, and EEG spectrum, respectively.
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Science sub-journal: Cao Xiong/Feng Yanqiu's team found that astrocytes dysfunction led to abnormal resting functional connectivity in patients with depression
Time of Update: 2023-01-05
Wu from the University of Hong Kong are co-corresponding authors of the paper。 Link to the paper: style="color: rgb(136, 136, 136);font-size: 12px;letter-spacing: normal;" _mstmutation="1" _istranslated="1"> open reprint Welcome to Moments and WeChat groups Depression is a common mental disorder, mainly manifested as low mood, decreased interest, slow thinking, poor diet and sleep and other symptoms, but also produce pessimism, world-weariness and even suicidal tendencies.
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Rapid termination of status epilepticus seizures? There is an order of treatment!
Time of Update: 2023-01-05
➤Refractory status epilepticus (RSE): RSE is defined as the inability to terminate the seizure after using a sufficient dose of 2~3 anti-SE seizure drugs (usually benzodiazepines followed by another or two antiepileptic drugs), and the electroencephalogram (EEG) shows a seizure-like discharge.
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Scientists developing specific gene therapies have the potential to completely cure brain circuit diseases such as epilepsy
Time of Update: 2023-01-04
Summary in EnglishSeveral neurodevelopmental and neuropsychiatric disorders are characterized by intermittent episodes of pathological activity.
Summary in EnglishSeveral neurodevelopmental and neuropsychiatric disorders are characterized by intermittent episodes of pathological activity.
Summary in EnglishSeveral neurodevelopmental and neuropsychiatric disorders are characterized by intermittent episodes of pathological activity.
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Alzheimer's & Dementia: Alcohol use disorder is associated with a higher risk of Alzheimer's disease and Parkinson's disease
Time of Update: 2023-01-04
Cumulative incidence of Parkinson's disease after index date in individuals with alcohol use disorder and matched controls; (A) white subpopulation (female N = 68,460, male N = 119,808) ;(B) Spanish subpopulation (female 7210, male 20442) ;(C) black subpopulation (female N = 8294, male N = 15,234) ;(D) Asian subpopulation (female 1352, male 3304)In separate analyses of black, white, and Hispanic individuals, patients with AUD had a higher risk of Alzheimer's disease (adjusted HR≥ 1.
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A new review of Nat Rev Neurol: Emerging roles of gene-environment interactions-epigenetics in Alzheimer's disease
Time of Update: 2023-01-04
Although previous studies have confirmed that some environmental factors (diet, lifestyle, smoking, drinking, pollution) are risk factors for AD, it is only in recent years that the molecular mechanisms underlying gene-environment interactions have been gradually understood.
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Neurology: Body mass index, abdominal obesity, and Parkinson's disease incidence in French women from the E3N cohort study
Time of Update: 2023-01-04
Recently, a study published in Neurology used lagged analysis to examine the relationship between BMI and abdominal obesity and PD incidence to elucidate potential reverse causality and compare BMI trajectories in patients with previously diagnosed and matched controls.
