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Multiple sclerosis has a long way to explore, and disease modification therapy will still seek ECTRIMS 2022
Time of Update: 2023-01-06
Figure 1: BTK inhibitors significantly reduced disease scores and serum NfH levels in EAE mice▌ Not afraid of the test, the efficacy and safety of treatment for up to 2 years are still goodA phase 2b study published in the top journal The Lancet Neurology in 2021 showed that 12 weeks of tolebrutinib treatment resulted in a dose-dependent reduction in the number of new gadolinium-enhancing lesions in MS patients with a favorable safety profile [7].
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Multiple sclerosis has a long way to explore, and disease modification therapy will still seek ECTRIMS 2022
Time of Update: 2023-01-06
Figure 1: BTK inhibitors significantly reduced disease scores and serum NfH levels in EAE mice▌ Not afraid of the test, the efficacy and safety of treatment for up to 2 years are still goodA phase 2b study published in the top journal The Lancet Neurology in 2021 showed that 12 weeks of tolebrutinib treatment resulted in a dose-dependent reduction in the number of new gadolinium-enhancing lesions in MS patients with a favorable safety profile [7].
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Neuron Liu Kai's team found that activating type II interferon and cGAS-STING signaling pathways in the nervous system can promote axon regeneration
Time of Update: 2023-01-06
On November 11, 2022, Liu Kai's research group of the Hong Kong University of Science and Technology published a long article "Driving Axon Regeneration by Orchestrating Neuronal and Non-neuronal Innate Immune Responses via the" in Neuron IFNγ-cGAS-STING Axis, found that by knocking out PTPN2 and adding type II interferon stimulated genes (ISGs) in neurons including the cGAS-STING pathway, it was possible to activate interferon stimulated genes (ISGs).
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For the first time, the Xiangya Hospital team confirmed that there is no causal relationship between Alzheimer's disease and age-related macular degeneration
Time of Update: 2023-01-06
The IVW method was used to study the bidirectional causality table between genetic susceptibility to late AMD and ADThe results showed that the genetic susceptibility to late AMD was not related to AD risk, and there was a consistent zero association across different AD datasets (see table above, P values were all greater than 0.
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Cell: The structural basis of the mechanism of action of the potent analgesic fentanyl and morphine revealed by Shanghai Medicine
Time of Update: 2023-01-06
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin and Wang Mingwei of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences cooperated to publish a research paper en
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Cell: The structural basis of the mechanism of action of the potent analgesic fentanyl and morphine revealed by Shanghai Medicine
Time of Update: 2023-01-06
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin and Wang Mingwei of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences cooperated to publish a research paper en
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The Transl Psychiatry-Suiqiang Zhu/Zhou Zhu team revealed that structural disconnection due to stroke predicts the risk of depression after stroke
Time of Update: 2023-01-06
Written by Pan Chensheng, Zhu ZhouResponsible editor—Wang Sizhen, Fang YiyiEditor—Summer LeafPost-stroke depression (PSD) occurs in about one-third of stroke people, and is associated with poor post-s
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Expert Review: Cell Xu Huaqiang/Xie Xin/Wang Mingwei/Zhuang Youwen collaborated to reveal the mechanism of action of the powerful analgesics fentanyl and morphine
Time of Update: 2023-01-06
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin's team and Wang Mingwei's team from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences published a long article entitled Molecular recognition of morphine and fentanyl by the human μ-opioid online Research paper by Receptor.
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Neurology—Liyuan Han's team systematically assesses the disease burden of stroke among young adults globally, regionally and nationally
Time of Update: 2023-01-06
Article conclusion and discussion, inspiration and prospectsAlthough age-standardized morbidity, mortality, and DALY rates of ischaemic stroke in young adults declined globally between 1990 and 2019, in low- and middle- and low-SDI regions such as North Africa, the Middle East and Southeast Asia, The burden of ischaemic stroke is still increasing.
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AD: The team of Du Yifeng/Qiu Chengxuan of Shandong Provincial Hospital found that more than a quarter of China's rural elderly over 60 years old have mild cognitive impairment
Time of Update: 2023-01-06
After adjusting for age, education, clinical situation, and APOE genotype, there were no significant sex differences in the overall prevalence of MCI, aMCI, and naMCI.
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AD: The team of Du Yifeng/Qiu Chengxuan of Shandong Provincial Hospital found that more than a quarter of China's rural elderly over 60 years old have mild cognitive impairment
Time of Update: 2023-01-06
After adjusting for age, education, clinical situation, and APOE genotype, there were no significant sex differences in the overall prevalence of MCI, aMCI, and naMCI.
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"Cell" sub-journal: the first discovery of the neural circuit of sleep to consolidate social memory, the latest research results of the Chen Xiaowei/Qin Han team of the Army Medical University
Time of Update: 2023-01-06
Using techniques such as calcium flow in vivo imaging, optogenetics, and in vivo single-cell electrophysiology, they found that neurons projected by the hypothalamic supramammary nucleus (SuM) into the CA2 region of the hippocampus are highly activated during REM sleep, and that specific inhibition of this group of neurons during REM sleep impairs social memory.
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"Cell" sub-journal: the first discovery of the neural circuit of sleep to consolidate social memory, the latest research results of the Chen Xiaowei/Qin Han team of the Army Medical University
Time of Update: 2023-01-06
Using techniques such as calcium flow in vivo imaging, optogenetics, and in vivo single-cell electrophysiology, they found that neurons projected by the hypothalamic supramammary nucleus (SuM) into the CA2 region of the hippocampus are highly activated during REM sleep, and that specific inhibition of this group of neurons during REM sleep impairs social memory.
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Nature Communications: Inhibit neural circuits for undesirable motivational behavior, or reduce drug addiction
Time of Update: 2023-01-06
1038/s41467-022-34517-wThe images in the article are from referencesPVT excitatorycan also blockFigure 2: NAc region small albumin neurons mediate inhibitory reward behavior3Opioids dissociate their receptors and inhibit rewarding effectsIntraperitoneal injection of the opioid heroin significantly reduced the neuronal activity of PVT →NAc circuit.
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Nature: From severe paralysis to resumption of walking, a miracle of recovery from 9 people with spinal cord injuries
Time of Update: 2023-01-06
▲ Nine paralyzed patients recovered their ability to walk to varying degrees (Image source: Reference [4]; Credit: NeuroRestore-Jimmy Ravier）What's even more exciting is that behind the miracles of recovery from these spinal cord injury patients, researchers have identified specific neurons that play a key role in regaining the ability to walk — and in the future, manipulating these specific neurons may help more paralyzed patients regain motor function.
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Nature: From severe paralysis to resumption of walking, a miracle of recovery from 9 people with spinal cord injuries
Time of Update: 2023-01-06
▲ Nine paralyzed patients recovered their ability to walk to varying degrees (Image source: Reference [4]; Credit: NeuroRestore-Jimmy Ravier）What's even more exciting is that behind the miracles of recovery from these spinal cord injury patients, researchers have identified specific neurons that play a key role in regaining the ability to walk — and in the future, manipulating these specific neurons may help more paralyzed patients regain motor function.
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Classification of common seizures and recommended first-line treatment Knowledge card
Time of Update: 2023-01-06
How do people with different types of epilepsy need to be treated?Seizures are generally classified as systemic and focal origins.
How do people with different types of epilepsy need to be treated?Seizures are generally classified as systemic and focal origins.
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Classification of common seizures and recommended first-line treatment Knowledge card
Time of Update: 2023-01-06
How do people with different types of epilepsy need to be treated?Seizures are generally classified as systemic and focal origins.
How do people with different types of epilepsy need to be treated?Seizures are generally classified as systemic and focal origins.
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Nature: Mediating the "new culprit" of AD deposition, amyloid medin in cerebral blood vessels promotes Aβ aggregation
Time of Update: 2023-01-06
1038/s41586-022-05440-3The images in the article are from referencesFigure 1: medin promotes the deposition of cerebral vascular Aβ2medin mediates cognitive impairment in AD patients by inducing CAATo study the role of medin in the pathological process in AD patients, the researchers collected cortical samples from 16 AD deceased patients and found that medin had obvious colocalization with Aβ.
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Academician comments The study of "Cell" of the Chinese Academy of Sciences revealed the mechanism of action of morphine and fentanyl, and the powerful analgesic got rid of addiction is one step closer
Time of Update: 2023-01-06
The cooperation of Xu Huaqiang/Zhuang Youwen, Xie Xin's team and Wang Mingwei's team from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences revealed for the first time the mechanism of action of powerful analgesics fentanyl and morphine to recognize and activate μ opioid receptors (μOR), and systematically explored and deepened the understanding and understanding of the mechanism of μOR signaling regulation.
