-
Epilepsy is one step closer to precision medicine
Time of Update: 2023-02-01
W. McDonald, MD, PhDA questionnaire study provides important real-world evidence that for most children and adults, making a causative genetic diagnosis influences the epilepsy treatment regimen used by healthcare providers, which in turn improves seizure outcomes.
-
Molecular Psychiatry: The first large-sample clinical study shows that high polygenic risk scores for ADHD are associated with reduced cognitive risk in old age!
Time of Update: 2023-02-01
In people with brain Aβ deposition, the higher the ADHD-PRS score, the faster the decline in overall cognitive function and memory cognitive domain functionIn summary, this study cleverly uses ADHD-PRS score instead of the diagnosis of ADHD, and finds that ADHD-PRS score is a risk factor for cognitive decline, which can be used as an important reference value for clinically combining genetic and imaging information to predict cognitive decline in the elderly.
-
New research from the University of Washington reveals that manipulating the gut flora can reduce neurodegeneration in Alzheimer's disease!
Time of Update: 2023-02-01
" 。 The study, conducted in mice, found that gut bacteria — in part by producing compounds such as short-chain fatty acids — influence the behavior of immune cells throughout the body, including cells in the brain that can damage brain tissue and exacerbate neurodegeneration in conditions such as Alzheimer's disease.
-
SLEEP—The Han Fang/Yu Hongjie team estimated the incidence of narcolepsy for the first time in China and found that it increased during the 2009 H1N1 influenza pandemic
Time of Update: 2023-02-01
In China, Peking University People's Hospital first reported [5] that the incidence of narcolepsy increased significantly during the 2009 H1N1 influenza pandemic, three times that of the pre-epidemic level, and the number of cases in Beijing dropped to the pre-epidemic level two years after the end of the pandemic [6] 。 This result has been confirmed in studies in Shanghai [7] and Taiwan [8].
-
AD: Bull! Scientists have found that some centenarians are tolerant to the aggregation of Alzheimer's disease "toxic proteins"!
Time of Update: 2023-02-01
For people from the 100-plus and NBB cohorts, researchers evaluated the neuropathic status of Aβ, neurofibrillary tangles, and neuroinflammatory plaques (NPs) by National Institute on Aging (NIA) Amyloid stage [3], Braak stage [4], and Alzheimer's Disease Joint Registry Collaborative (CERAD) scores [5], respectively.
-
No aura vs migraine with aura? Look at these two gold diagnostic standards!
Time of Update: 2023-02-01
▼▼▼Click to read the original article to download the AppFor medical professionals onlyFor more guidelines for the diagnosis and treatment of common neurological diseases, go to the "Clinical Decision Assistant App"!
-
More than 200,000 people at the University of Hong Kong have shown that patients with heart failure have a higher risk of dementia
Time of Update: 2023-02-01
Mild white matter lesions are more common in patients with heart failure and increase with age, while moderate to severe white matter lesions are associated with cognitive impairment and dementia.
-
Do we need a new diagnosis of "acute anxiety disorder"?
Time of Update: 2023-01-07
A diagnosis of "acute anxiety disorder" can isolate the patient's current state from a relatively mild chronic condition – the patient is going through a difficult special period in which functional impairment is quite severe.
-
Three key data for delays in the diagnosis and treatment of bipolar disorder
Time of Update: 2023-01-07
In this systematic review and meta-analysis of 59 studies and more than 40,000 patients, the median duration of "delayed help", "delayed diagnosis", and "delayed treatment" in bipolar disorder was 3.
-
Interview with Professor Haiqing Song: Diagnosis strategies for the etiology of cardiogenic stroke from the latest SCAI PFO management guidelines
Time of Update: 2023-01-07
From a clinical point of view, cardiogenic stroke has some characteristics: (1) it tends to have a more acute onset, a more severe condition, and is prone to early bleeding transformation of infarction; (2) Imaging features: lesions are sometimes multiple, and often have foci in the cross-vascular blood supply basin.
-
Concise advice on using melatonin to aid sleep
Time of Update: 2023-01-07
Short-term, early, low dose Melatonin, an endogenous neurohormone involved in circadian rhythm regulation, is often described as a sleep-promoting neurotransmitter, but it may be more accurate to call it a "dark hormone.
-
How to improve depression through lifestyle? These questions are worth asking
Time of Update: 2023-01-07
Quit smoking"How many cigarettes a day?""How long after waking up do I start smoking the first one?""Where do you usually smoke?" What time to draw?
Quit smoking"How many cigarettes a day?""How long after waking up do I start smoking the first one?""Where do you usually smoke?" What time to draw?
-
In patients with acute psychosis, assessing the physical condition can make doctors safer
Time of Update: 2023-01-07
Fig. 1 Palmar lesionsFig. 1 Palmar lesionsFig. 2 Plantar lesionsFig. 2 Plantar lesionsClinical implicationsClinical implicationsThe clinical manifestations of syphilis are complex and often confused with a variety of disorders.
The clinical manifestations of syphilis are complex and often confused with a variety of disorders.
-
Mild to moderate depression: exercise, antidepressants, and combination therapy?
Time of Update: 2023-01-07
03; I2=46%）。 conclusion This is the first network meta-analysis comparing exercise, antidepressants, and combination therapy in adults with non-major depression.
This is the first network meta-analysis comparing exercise, antidepressants, and combination therapy in adults with non-major depression.
-
A table summary: predictors of satisfactory/unsatisfactory efficacy of lithium salts
Time of Update: 2023-01-07
, based on the existing high-quality review, summarized the "probable" and "possible" predictors of the ideal or unsatisfactory efficacy of lithium salt in the treatment of bipolar disorder as shown in Table 1: Table 1 Predictors of satisfactory/unsatisfactory efficacy of lithium salts It is important to note that these factors are not absolute, especially those that are "likely" predictors (eg, gender).
-
Nature: In the face of setbacks, lie flat or resist? Scientists reveal that midbrain dopaminergic neurons regulate stress resistance
Time of Update: 2023-01-07
Click on the blue word to follow usPost-traumatic stress or chronic stress events can cause depression or anxiety, but in the population as a whole, a small proportion of people develop mood disorders
-
With so many scale tools, how exactly do you identify bipolar disorder with rapid cycling?
Time of Update: 2023-01-07
Rapid cycling, defined as at least four mood episodes in the preceding 12 months that meet the diagnostic criteria for manic, hypomanic, or major depressive episodes, is a clinical feature of the course of bipolar disorder rather than a subtype of the disease.
-
Nature Communications: Inhibit neural circuits for undesirable motivational behavior, or reduce drug addiction
Time of Update: 2023-01-06
1038/s41467-022-34517-wThe images in the article are from referencesPVT excitatorycan also blockFigure 2: NAc region small albumin neurons mediate inhibitory reward behavior3Opioids dissociate their receptors and inhibit rewarding effectsIntraperitoneal injection of the opioid heroin significantly reduced the neuronal activity of PVT →NAc circuit.
-
After publishing acupuncture research in Nature and revealing the existence of acupuncture points, Harvard full professor Ma Qiufu returned to China and joined Westlake University
Time of Update: 2023-01-06
In October 2021, Ma Qiufu's team and others published a paper in Nature to achieve a historic breakthrough in acupuncture research, which showed a class of PROKR2-Cre-labeled dorsal root ganglia (DRG) Sensory neurons are essential for low-intensity acupuncture stimulation to activate the vagus-adrenal anti-inflammatory pathway.
-
The sound of uh may be caused by medication!
Time of Update: 2023-01-06
*For reference by medical professionals only, the highest incidence of antimicrobials and adrenal glucocorticoid hiccups (diaphragmatic spasm) is due to local diaphragm, phrenic nerve, The vagus nerve or the central nervous system above the cervical medulla 3~5 is stimulated, causing paroxysmal spasm of one or both diaphragms, accompanied by sudden closure of the glottis during inhalation, making a special sound.
