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Heavy! The Institute of Chemistry of the Chinese Academy of Sciences today Science can simulate brain communication!
Time of Update: 2023-02-01
Here, researchers Mao Lanqun and Yu Ping of the Institute of Chemistry, Chinese Academy of Sciences, successfully realized neuromorphic functions using polyelectrolyte-confined fluid memristors (PFMs), in which confined polyelectrolyte-ion interactions help lag ion transport, thereby producing ion memory effects.
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Science sub-journal: AAV delivers micro-DMD gene, treatment of DMD golden retriever models
Time of Update: 2023-02-01
Link: style="color: rgb(136, 136, 136);font-size: 12px;letter-spacing: normal;" _mstmutation="1" _istranslated="1"> Open reprint, welcome to forward to Moments and WeChat groups Written byWang Cong EditorWang Duoyu TypesettingShui Chengwen Duchenne muscular dystrophy (DMD) is a single-gene disease with a relatively high incidence, Mutations in the gene encoding dystrophin on the X chromosome, resulting in the inability to produce enough dystrophin, the patient's muscle tissue is gradually replaced by fat and fibrotic tissue, and about 1 in 5,000 newborn male babies is affected.
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Express In view of the common genetic risk of Parkinson's disease, Xinrui has reached a gene therapy cooperation
Time of Update: 2023-02-01
▲If you have any business needs, please press and hold to scan the QR code above, or▎WuXi AppTec content team editorNeurocrine Biosciences and Voyager Therapeutics today announced a new strategic collaboration to advance multiple gene therapies for the treatment of neurological disorders.
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7 auxiliary examination methods to diagnose early-onset Parkinson's!
Time of Update: 2023-02-01
[5] Chinese expert consensus on the diagnosis and treatment of early-onset Parkinson's disease ▼▼▼Click to read the original article to download the AppFor medical professionals onlyFor more guidelines for the diagnosis and treatment of common neurological diseases, go to the "Clinical Decision Assistant App"!
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J Neuroinflammation—Kailiang Zhou/Wenfei Ni team reveals a novel mechanism of mitochondrial targeted antioxidant peptides in the treatment of spinal cord injury
Time of Update: 2023-02-01
" lysosomal membrane permeabilization", using mouse spinal cord contusion models to carry out a series of studies, clarified that SS-31 improved the inflammatory environment of spinal cord injury mice and promoted the recovery of spinal cord injury function, and was found for the first time SS-31 improves lysosomal membrane permeability by inhibiting the phosphorylation level of cytoplasmic phospholipase A2 (cPLA2) by the p38-MAPK signaling pathway, thereby improving nerve cell pyrosis and impaired autophagy flow.
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Mol Cancer (IF=41) Mao Jie/Wu Dinglan/Zhang Longji collaborated to discover potential new ways to treat glioblastoma
Time of Update: 2023-02-01
iNatureGlioblastoma (GBM) is the most aggressive and lethal human brain tumor, and despite combination therapies including surgical resection, radiotherapy, and chemotherapy, the prognosis for patients remains poor.
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"Breakthrough" new drug for Alzheimer's disease approved: delayed 27% of brain decline, but the $26,500/year price is disputed
Time of Update: 2023-02-01
Figure 1 Summary review of Leqembi released by the FDA Center for Drug Evaluation and Research (Source: [1]) 01Leqembi met all key secondary endpoints in the clinic Study 201 was a multicenter, randomized, double-blind, placebo-controlled, parallel-group study of 856 patients with mild cognitive impairment (MCI) due to AD or mild AD dementia.
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Electrical stimulation helps paralyzed people walk again
Time of Update: 2023-02-01
The research team said in Nature that nine subjects in the same trial — three of whom were totally paralyzed and unconscious in their legs — regained the ability to walk through EES treatment combined with training through spinal implants.
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Redox Biol—Xinong Liu Zhigang et al. revealed for the first time that methionine-restricted diets can improve AD cognitive dysfunction
Time of Update: 2023-02-01
Professor Liu Zhigang and others published a title entitled " Effects of methionine intake on cognitive function in mild cognitive impairment patients and APP/PS1 Alzheimer's Disease model mice: Role of the cystathionine-β-synthase/H 2S pathway" research paper, the authors first studied in a survey of 45 people diagnosed with mild cognitive impairment (Mild Cognitive Impairment, MCI) and a cohort of 61 healthy controls without cognitive impairment found a positive association between methionine intake and an increased risk of MCI.
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Professor Tang Yamei's team at Sun Yat-sen University discovered a novel mechanism by which microglia infiltrate the brain parenchyma through chemotaxis peripheral CD8⁺ T cells Cell Press Dialogue Scientists
Time of Update: 2023-02-01
Life SciencesLife scienceOn January 5, 2023, Professor Tang Yamei's team from the Brain Science Research Center of Sun Yat-sen Memorial Hospital of Sun Yat-sen University published a report entitled "
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Commun Biol—Li's infant team revealed that adrenergic signaling in anterior cingulate cortical astrocytes is involved in pain-related aversion memory formation in rats
Time of Update: 2023-02-01
, Commun Biol, 2023 Article conclusion and discussion, inspiration and prospectsIn summary, Professor Li established a behavioral paradigm for assessing painful negative memory in rats, and on this basis, they further discovered the indispensable role of anterior cingulate cortex (ACC) astrocytes in pain-averse memory, which binds to norepinephrine β2 receptors The norepinephrine released by blue spots (LCs) into ACC neurons regulates synaptic plasticity in neighboring ACC neurons, thereby affecting the formation and consolidation of pain-averse memories.
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Express New strategies for targeting "drug-free" targets! AbbVie reached a $540 million partnership
Time of Update: 2023-02-01
▲Anima Biotech's technology platform can screen specific small molecule compounds for a variety of proteins that regulate mRNA translation (Image source: Anima Biotech official website)Under the agreement, Anima will receive an upfront payment of $42 million and is eligible for up to $540 million based on AbbVie's selection and R&D and commercialization milestones across the three targets.
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Accurately reflect cognitive decline and the risk of Alzheimer's disease, and you can rely on this method!
Time of Update: 2023-02-01
Click "Read Original" to see more information~The researchers collated brain MRIs of 4681 cognitively normal participants, some of whom went on to develop cognitive decline or Alzheimer's disease later in life.
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Science: Rewrite the textbook! Scientists have discovered the fourth layer of the brain, the meningeal structure, which plays a role in material exchange and immune surveillance
Time of Update: 2023-02-01
, Science 379, 84–88 (2023)，A mesothelium divides the subarachnoid space into functional compartmentsThe images in the article are from referencesClick on the blue word to follow usThe central nervous system is separated by the dura, arachnoid and pia mater, which has the effect of supporting and nourishing the brain.
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How to stay away from stroke? The key is to do these things well!
Time of Update: 2023-02-01
Come to the "Doctor Station Web Page Version" and take a look 👇*For medical professionals onlyManagement of common risk factors that can be intervened is important for effective stroke prevention and control.
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STTT: Chinese scientists released autopsy reports on the brains of new crown infected patients, and found that monocytic encephalitis and blood-brain barrier damage were found in clinical findings
Time of Update: 2023-02-01
▲Damaged blood-brain barrier under electron microscopyAfter comparing the cytokine profiles that cause encephalitis associated with the new crown infection with those that cause lung and liver damage, Bian Xiuwu's team found that the brain, lung and liver tissues of new crown infected people contained more IL-1, IL-8, IL-12, IL-18 and TNF-α, which means that these pro-inflammatory cytokines may contribute to the occurrence of systemic inflammatory storms.
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Management strategies for patients with heart, kidney, and mental chronic diseases under the epidemic, one article get!
Time of Update: 2023-02-01
Come to the "Doctor Station Web Page Version" and take a look 👇*For medical professionals onlyClinical medication, individualization is still the focus!In the last issue, we talked about the interaction and use strategies between new crown antiviral drugs and commonly used cardiovascular disease treatment drugs (click to view the original article).
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Postpartum headache, loss of consciousness, this reason is not simple!
Time of Update: 2023-02-01
*For medical professionals onlyClassic cases, layer by layerOrganize | Yuan WeizheIntracranial venous sinus thrombosis is a special type of cerebrovascular disease, often onset in wasting diseases, brain trauma, puerperium, blood diseases, heart disease, eye, nose and facial infections, meningitis, sepsis, etc.
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Febrile seizures: risks, assessment, and prognosis
Time of Update: 2023-02-01
chartSimple versus complicated febrile seizuresClassification: Key recommendations for practiceBest practices in neurologyNew developments on this topicOriginal link: PMID: 30932454Febrile seizures: risk, assessment, and prognosisFebrile Seizures: Risks, Evaluation, and Prognosis01.
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Heavy! After 6 years, the "Chinese Clinical Guidelines for the Treatment of Nerve Repair for Idiopathic Facial Nerve Palsy (2022 Edition)" was released!
Time of Update: 2023-02-01
Of peripheral facial palsy, 75% are idiopathic facial palsy and about 25% are due to other causes, which need to be differentiated in combination with other conditions:(1) Guillain-Barré syndrome: acute or subacute onset, often with a history of fever or diarrhea prodromal infection, sudden brackey paralysis of limbs, accompanied by bilateral peripheral facial palsy, protein-cell separation in cerebrospinal fluid.
