-
Neurology—Liyuan Han's team systematically assesses the disease burden of stroke among young adults globally, regionally and nationally
Time of Update: 2023-01-06
Article conclusion and discussion, inspiration and prospectsAlthough age-standardized morbidity, mortality, and DALY rates of ischaemic stroke in young adults declined globally between 1990 and 2019, in low- and middle- and low-SDI regions such as North Africa, the Middle East and Southeast Asia, The burden of ischaemic stroke is still increasing.
-
Nature: From severe paralysis to resumption of walking, a miracle of recovery from 9 people with spinal cord injuries
Time of Update: 2023-01-06
▲ Nine paralyzed patients recovered their ability to walk to varying degrees (Image source: Reference [4]; Credit: NeuroRestore-Jimmy Ravier）What's even more exciting is that behind the miracles of recovery from these spinal cord injury patients, researchers have identified specific neurons that play a key role in regaining the ability to walk — and in the future, manipulating these specific neurons may help more paralyzed patients regain motor function.
-
Nature: From severe paralysis to resumption of walking, a miracle of recovery from 9 people with spinal cord injuries
Time of Update: 2023-01-06
▲ Nine paralyzed patients recovered their ability to walk to varying degrees (Image source: Reference [4]; Credit: NeuroRestore-Jimmy Ravier）What's even more exciting is that behind the miracles of recovery from these spinal cord injury patients, researchers have identified specific neurons that play a key role in regaining the ability to walk — and in the future, manipulating these specific neurons may help more paralyzed patients regain motor function.
-
For the first time, the Xiangya Hospital team confirmed that there is no causal relationship between Alzheimer's disease and age-related macular degeneration
Time of Update: 2023-01-06
The IVW method was used to study the bidirectional causality table between genetic susceptibility to late AMD and ADThe results showed that the genetic susceptibility to late AMD was not related to AD risk, and there was a consistent zero association across different AD datasets (see table above, P values were all greater than 0.
-
Cell: The structural basis of the mechanism of action of the potent analgesic fentanyl and morphine revealed by Shanghai Medicine
Time of Update: 2023-01-06
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin and Wang Mingwei of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences cooperated to publish a research paper en
-
Cell: The structural basis of the mechanism of action of the potent analgesic fentanyl and morphine revealed by Shanghai Medicine
Time of Update: 2023-01-06
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin and Wang Mingwei of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences cooperated to publish a research paper en
-
"Cell" sub-journal: the first discovery of the neural circuit of sleep to consolidate social memory, the latest research results of the Chen Xiaowei/Qin Han team of the Army Medical University
Time of Update: 2023-01-06
Using techniques such as calcium flow in vivo imaging, optogenetics, and in vivo single-cell electrophysiology, they found that neurons projected by the hypothalamic supramammary nucleus (SuM) into the CA2 region of the hippocampus are highly activated during REM sleep, and that specific inhibition of this group of neurons during REM sleep impairs social memory.
-
"Cell" sub-journal: the first discovery of the neural circuit of sleep to consolidate social memory, the latest research results of the Chen Xiaowei/Qin Han team of the Army Medical University
Time of Update: 2023-01-06
Using techniques such as calcium flow in vivo imaging, optogenetics, and in vivo single-cell electrophysiology, they found that neurons projected by the hypothalamic supramammary nucleus (SuM) into the CA2 region of the hippocampus are highly activated during REM sleep, and that specific inhibition of this group of neurons during REM sleep impairs social memory.
-
Multiple sclerosis has a long way to explore, and disease modification therapy will still seek ECTRIMS 2022
Time of Update: 2023-01-06
Figure 1: BTK inhibitors significantly reduced disease scores and serum NfH levels in EAE mice▌ Not afraid of the test, the efficacy and safety of treatment for up to 2 years are still goodA phase 2b study published in the top journal The Lancet Neurology in 2021 showed that 12 weeks of tolebrutinib treatment resulted in a dose-dependent reduction in the number of new gadolinium-enhancing lesions in MS patients with a favorable safety profile [7].
-
Multiple sclerosis has a long way to explore, and disease modification therapy will still seek ECTRIMS 2022
Time of Update: 2023-01-06
Figure 1: BTK inhibitors significantly reduced disease scores and serum NfH levels in EAE mice▌ Not afraid of the test, the efficacy and safety of treatment for up to 2 years are still goodA phase 2b study published in the top journal The Lancet Neurology in 2021 showed that 12 weeks of tolebrutinib treatment resulted in a dose-dependent reduction in the number of new gadolinium-enhancing lesions in MS patients with a favorable safety profile [7].
-
"Seeing in pairs" layer by layer, what is the reason?
Time of Update: 2023-01-06
, did not support acute cerebrovascular disease and intracranial mass lesions; The patient began with drooping eyes and face, double vision, no abnormalities in the current electroneurography and negative neostigmine test→ which does not support myasthenia gravis; Glucose tolerance test does not support diabetes → so diabetic-related peripheral nerve damage is not considered →; At present, the possibility of painful ophthalmoplegia is considered to be high, and it is necessary to improve orbital imaging to further clarify.
-
Good intestines, good brains! Chinese scientists' latest discovery: This humble probiotic can change the trend of Parkinson's disease?
Time of Update: 2023-01-06
Bifidobacterium breve CCFM1067 alleviates MPTP-induced motor dysfunction in mice, and dopamine (DA) in the brain works in tandem with the glutamate system to control the body's motor and cognitive functions 。 The synthesis of DA is influenced by the rate-limiting enzyme tyrosine hydroxylase (TH), and motor symptoms of PD occur when TH levels fall below a certain threshold 。 Histopathological staining results showed that the intake of B.
-
"Nature" blockbuster: fight brain aging, treat Alzheimer's disease, this cell has a big effect
Time of Update: 2023-01-06
The Nature paper today shows a potential new direction in which immune cells around the brain can improve the brain's efficiency at removing waste, helping to reduce the aggregation of toxic proteins.
-
New breakthrough in brain-computer interface: Zhang Fulun's team helps paralyzed aphasia "speak" by decoding brain activity
Time of Update: 2023-01-06
75em;"> style="margin-bottom: 0px;text-align: left;margin-left: 8px;margin-right: 8px;line-height: normal;">Open reprint, welcome to forward to Moments and WeChat groups EditorWang Duoyu TypesettingShui Chengwen Neuroprosthesis is a device that replaces missing nervous system function and is expected to restore the ability to communicate in patients who are unable to speak or type due to paralysis.
-
Changes in consciousness after a fall in patients with spinal cord injury Clinical reasoning
Time of Update: 2023-01-06
What are the next steps for the assessment?Part IIIPunctate diffusion restriction and microbleeding suggest that the lesion involves small blood vessels, and differential diagnoses include vasculitis, microangiopathy, or embolism.
-
There are so many vertigo terms, how to distinguish them?
Time of Update: 2023-01-06
Come to the "doctor's station" and take a look 👇Vertigoof self-movement that is distorted during normal head movement, in short, the feeling that oneself is moving(not actually moving),which is different from external vertigo, which refers to the "external" visual motor sensation or oscilloscope[vestibular visual symptoms, in short, seeing something moving (in fact neither you nor the thing moving)].
-
Primary VS secondary trigeminal neuralgia, what is the difference?
Time of Update: 2023-01-06
Download the Decision Assistant App, the guide is free at any time~References:[1] Chinese expert consensus on the diagnosis and treatment of trigeminal neuralgia▼▼▼Click to read the original article to download the App*For medical professionals onlyScientific response to the "world's first pain"!
-
For the first time, the journal Nature found that the abnormal protein construction of Parkinson's disease is inseparable from this molecule
Time of Update: 2023-01-06
▎ WuXi AppTec content team editor Parkinson's disease currently plagues more than 6 million patients worldwide, and the distinctive feature of the disease is abnormal α-synuclein clumps in the brain 。
-
Dev Cell—Tian Ye's team found that the GPCR signaling pathway coordinates the body's mitochondrial stress response in a pair of sensory neurons
Time of Update: 2023-01-06
Written by Liu Yangli, edited by Zhou Jun -- Wang Sizhen, edited by Fang Yiyi -- Xia YeThe nervous system plays an important role in sensing and coordinating the body's stress response. When the mitoc
-
Academician Cell Review! Xu Huaqiang/Xie Xin/Wang Mingwei/Zhuang Youwen revealed the mechanism of action of morphine and fentanyl, and powerful analgesics got rid of addiction one step further
Time of Update: 2023-01-06
iNatureOn November 10, 2022, the team of Xu Huaqiang, Xie Xin, and Wang Mingwei, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, cooperated in publishing a long article entitled "Mo
