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JAMA Sub-issue: Discover blood markers to evaluate the efficacy of Alzheimer's disease drugs!
Time of Update: 2023-01-06
At baseline, plasma pTau217 levels in AD patients were significantly positively correlated with brain amyloid plaques and Tau protein deposition on Aβ and Tau PET imagingNext, the researchers analyzed changes in plasma biomarkers in AD patients after Donanemab treatment.
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Changes in consciousness after a fall in patients with spinal cord injury Clinical reasoning
Time of Update: 2023-01-06
What are the next steps for the assessment?Part IIIPunctate diffusion restriction and microbleeding suggest that the lesion involves small blood vessels, and differential diagnoses include vasculitis, microangiopathy, or embolism.
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Hu Gang's team revealed that microglia promote toxic astrocytes formation and induce depression-like behavior
Time of Update: 2023-01-06
1038/s41586-022-05328-2The images in the article are from referencesFigure 1: Increased activation of hippocampal neurotoxic astrocytes after stress2NLRP3 regulates the increase of astrocytes in the hippocampusGiven that NLRP3 regulates phenotypic transitions in A1 astrocytes and increases hippocampal NLRP3 levels after CMS, they constructed NLRP3 total knockout mice and found that knocking out NLRP3 was able to attenuate CMS-induced depression-like behavioral disorders, reduce the number of hippocampal A1 astrocytes, and attenuate synaptic protein loss.
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"Seeing in pairs" layer by layer, what is the reason?
Time of Update: 2023-01-06
, did not support acute cerebrovascular disease and intracranial mass lesions; The patient began with drooping eyes and face, double vision, no abnormalities in the current electroneurography and negative neostigmine test→ which does not support myasthenia gravis; Glucose tolerance test does not support diabetes → so diabetic-related peripheral nerve damage is not considered →; At present, the possibility of painful ophthalmoplegia is considered to be high, and it is necessary to improve orbital imaging to further clarify.
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Frontier Science: Seizure frequency reduced by 80%! Innovative gene therapies show amazing results
Time of Update: 2023-01-06
▲If you have any business needs, please press and hold to scan the QR code above, or▎WuXi AppTec content team editorScientists at University College London (UCL) have successfully developed a method that can reduce the excitability of overactive brain cells, which can effectively treat epilepsy - the seizures of the mice in the experiment fell by an average of 80%.
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Frontier Science: Seizure frequency reduced by 80%! Innovative gene therapies show amazing results
Time of Update: 2023-01-06
▲If you have any business needs, please press and hold to scan the QR code above, or▎WuXi AppTec content team editorScientists at University College London (UCL) have successfully developed a method that can reduce the excitability of overactive brain cells, which can effectively treat epilepsy - the seizures of the mice in the experiment fell by an average of 80%.
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Good intestines, good brains! Chinese scientists' latest discovery: This humble probiotic can change the trend of Parkinson's disease?
Time of Update: 2023-01-06
Bifidobacterium breve CCFM1067 alleviates MPTP-induced motor dysfunction in mice, and dopamine (DA) in the brain works in tandem with the glutamate system to control the body's motor and cognitive functions 。 The synthesis of DA is influenced by the rate-limiting enzyme tyrosine hydroxylase (TH), and motor symptoms of PD occur when TH levels fall below a certain threshold 。 Histopathological staining results showed that the intake of B.
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Academician comments The study of "Cell" of the Chinese Academy of Sciences revealed the mechanism of action of morphine and fentanyl, and the powerful analgesic got rid of addiction is one step closer
Time of Update: 2023-01-06
The cooperation of Xu Huaqiang/Zhuang Youwen, Xie Xin's team and Wang Mingwei's team from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences revealed for the first time the mechanism of action of powerful analgesics fentanyl and morphine to recognize and activate μ opioid receptors (μOR), and systematically explored and deepened the understanding and understanding of the mechanism of μOR signaling regulation.
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Nature: Cai's team reveals how the Alzheimer's disease gene APOE4 damages the brain and finds potential therapies
Time of Update: 2023-01-06
Paper link: style="color: rgb(136, 136, 136);font-size: 12px;" _mstmutation="1" _istranslated="1"> open reprint, welcome to forward to the circle of friends and WeChat group Written by NagashiEditorWang DuoyuTypesettingWater writingAlzheimer's disease (AD), commonly known as "Alzheimer's disease", is a type of central nervous system degenerative disease that mainly occurs in the elderly and is characterized by progressive cognitive dysfunction and behavioral damage.
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The Transl Psychiatry-Suiqiang Zhu/Zhou Zhu team revealed that structural disconnection due to stroke predicts the risk of depression after stroke
Time of Update: 2023-01-06
Written by Pan Chensheng, Zhu ZhouResponsible editor—Wang Sizhen, Fang YiyiEditor—Summer LeafPost-stroke depression (PSD) occurs in about one-third of stroke people, and is associated with poor post-s
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Academician Cell Review! Xu Huaqiang/Xie Xin/Wang Mingwei/Zhuang Youwen revealed the mechanism of action of morphine and fentanyl, and powerful analgesics got rid of addiction one step further
Time of Update: 2023-01-06
iNatureOn November 10, 2022, the team of Xu Huaqiang, Xie Xin, and Wang Mingwei, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, cooperated in publishing a long article entitled "Mo
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Neuron Mo Wei/Zhang Liang/Hu Jin of Xiamen University revealed that microglia sense amyloid plaque hardness through Piezo1 to limit the progression of Alzheimer's disease
Time of Update: 2023-01-06
Original link: 00954-0—END—The content is [iNature]iNatureThe pathological feature of Alzheimer's disease (AD) is extracellular amyloid-β (Aβ) plaques, the effect of which on the mechanical properties of surrounding brain tissue is unknown.
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Nature Communications: Inhibit neural circuits for undesirable motivational behavior, or reduce drug addiction
Time of Update: 2023-01-06
1038/s41467-022-34517-wThe images in the article are from referencesPVT excitatorycan also blockFigure 2: NAc region small albumin neurons mediate inhibitory reward behavior3Opioids dissociate their receptors and inhibit rewarding effectsIntraperitoneal injection of the opioid heroin significantly reduced the neuronal activity of PVT →NAc circuit.
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Patients can use efgartigimod early and seek greater benefits! 2022 AANEM Essence Hot Review No. 3
Time of Update: 2023-01-06
Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies, with impaired transmission of acquired neuro-muscle junctions (NMJs). 。 Acetylcholine receptor (AChR) antibodies are the mos
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For the first time, the Xiangya Hospital team confirmed that there is no causal relationship between Alzheimer's disease and age-related macular degeneration
Time of Update: 2023-01-06
The IVW method was used to study the bidirectional causality table between genetic susceptibility to late AMD and ADThe results showed that the genetic susceptibility to late AMD was not related to AD risk, and there was a consistent zero association across different AD datasets (see table above, P values were all greater than 0.
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Nature allows paralyzed patients to regain the ability to walk
Time of Update: 2023-01-06
Written by | JunSpinal cord injury (SCI) interrupts the connection from the brain and brainstem to the lumbar spinal cord, leaving the patient unable to walk and permanently paralyzed. Previous studie
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Nature: Mediating the "new culprit" of AD deposition, amyloid medin in cerebral blood vessels promotes Aβ aggregation
Time of Update: 2023-01-06
1038/s41586-022-05440-3The images in the article are from referencesFigure 1: medin promotes the deposition of cerebral vascular Aβ2medin mediates cognitive impairment in AD patients by inducing CAATo study the role of medin in the pathological process in AD patients, the researchers collected cortical samples from 16 AD deceased patients and found that medin had obvious colocalization with Aβ.
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Neuron Liu Kai's team found that activating type II interferon and cGAS-STING signaling pathways in the nervous system can promote axon regeneration
Time of Update: 2023-01-06
On November 11, 2022, Liu Kai's research group of the Hong Kong University of Science and Technology published a long article "Driving Axon Regeneration by Orchestrating Neuronal and Non-neuronal Innate Immune Responses via the" in Neuron IFNγ-cGAS-STING Axis, found that by knocking out PTPN2 and adding type II interferon stimulated genes (ISGs) in neurons including the cGAS-STING pathway, it was possible to activate interferon stimulated genes (ISGs).
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GnRH replacement therapy has had amazing benefits for people with Down syndrome
Time of Update: 2023-01-06
European researchers have observed that DS patients also have fewer neurons producing gonadotropin-releasing hormone (GnRH) over time, so they wanted to understand whether this was the cause of cognitive loss.
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Expert Review: Cell Xu Huaqiang/Xie Xin/Wang Mingwei/Zhuang Youwen collaborated to reveal the mechanism of action of the powerful analgesics fentanyl and morphine
Time of Update: 2023-01-06
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin's team and Wang Mingwei's team from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences published a long article entitled Molecular recognition of morphine and fentanyl by the human μ-opioid online Research paper by Receptor.